Cited by 1,728Cell death mechanisms and regulationMitochondrial Function and PathologyProtein Kinase Regulation and GTPase Signaling

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

Tournier, Cathy, Hess, Patricia, Yang, Derek D., Xu, Jie, Turner, Tod K., Nimnual, Anjaruwee, Bar-Sagi, Dafna, Jones, Stephen N. +2 more·2000·Science

Abstract

The c-Jun NH 2 -terminal kinase (JNK) is activated when cells are exposed to ultraviolet (UV) radiation. However, the functional consequence of JNK activation in UV-irradiated cells has not been established. It is shown here that JNK is required for UV-induced apoptosis in primary murine embryonic fibroblasts. Fibroblasts with simultaneous targeted disruptions of all the functional Jnk genes were protected against UV-stimulated apoptosis. The absence of JNK caused a defect in the mitochondrial death signaling pathway, including the failure to release cytochrome c. These data indicate that mitochondria are influenced by proapoptotic signal transduction through the JNK pathway.

Integrity signals

Registry

Crossref · 10.1126/science.288.5467.870

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Absence of JNK limits UV stress-induced mitochondrial release of cytochrome c.

    “The absence of JNK was previously shown to limit uv stress-induced mitochondrial release of cytochrome c (422),”

    From Redox regulation of mitochondrial function (2012) · cites this paper as [422]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J.
Affiliations
  • Howard Hughes Medical Institute (US)
  • University of Massachusetts Chan Medical School (US)
  • Stony Brook University (US)
  • Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794, USA.
Corresponding author
  • Yang, Derek D.
  • Davis, Roger J.
Venue
Science
Published
2000-05-05
Volume
288
Issue
5467
Pages
870-874
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W2119807130
Cited by
1,728
References
42
Citations by year
2026: 15 · 2025: 20 · 2024: 15 · 2023: 25 · 2022: 25 · 2021: 46 · 2020: 45 · 2019: 31 · 2018: 37 · 2017: 46 · 2016: 36 · 2015: 41 · 2014: 47 · 2013: 64 · 2012: 69
FWCI
49.56
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • eScholarship@UMassChan (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Keywords
JNK, c-Jun NH2-terminal kinase, cytochrome c release, mitochondrial apoptosis, UV-induced apoptosis, stress-induced apoptosis, embryonic fibroblasts
MeSH terms
Animals, Cell Count, Cell Division, Cells, Cultured, Cytochrome c Group, Enzyme Activation, Fibroblasts, Methyl Methanesulfonate, Mitochondria, Proteins, Proto-Oncogene Proteins, Ultraviolet Rays, Tumor Suppressor Protein p53, NF-kappa B, Apoptosis, Protein Serine-Threonine Kinases, Gene Targeting, Proto-Oncogene Proteins c-bcl-2, Caspases, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, JNK Mitogen-Activated Protein Kinases, Proto-Oncogene Proteins c-akt, Mice, Caspase 3, Caspase 9, Apoptotic Protease-Activating Factor 1, DNA Fragmentation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review