The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Reduced susceptibility to ischemic brain injury and N -methyl- d -aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice
Open accessAbstract
Cyclooxygenase-2 (COX-2), a prostanoid-synthesizing enzyme that contributes to the toxicity associated with inflammation, has recently emerged as a promising therapeutic target for several illnesses, ranging from osteoarthritis to Alzheimer's disease. Although COX-2 has also been linked to ischemic stroke, its role in the mechanisms of ischemic brain injury remains controversial. We demonstrate that COX-2-deficient mice have a significant reduction in the brain injury produced by occlusion of the middle cerebral artery. The protection can be attributed to attenuation of glutamate neurotoxicity, a critical factor in the initiation of ischemic brain injury, and to abrogation of the deleterious effects of postischemic inflammation, a process contributing to the secondary progression of the damage. Thus, COX-2 is involved in pathogenic events occurring in both the early and late stages of cerebral ischemia and may be a valuable therapeutic target for treatment of human stroke.
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Molecular targets in cerebral ischemia for developing novel therapeutics
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Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities
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Recent progress in phospholipase A2 research: From cells to animals to humans
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Metadata
- Authors
- Iadecola, C., Niwa, K., Nogawa, S., Zhao, X., Nagayama, M., Araki, E., Morham, S., & Ross, M. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-30
- Volume
- 98
- Issue
- 3
- Pages
- 1294-1299
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2156675756
- Cited by
- 411
- References
- 58
- FWCI
- 18.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Reduced susceptibility to ischemic brain injury and N -methyl- d -aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. https://app.cochat.ai/papers/10.1073/pnas.98.3.1294
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- Iadecola, C., Niwa, K., Nogawa, S., Zhao, X., Nagayama, M., Araki, E., Morham, S., & Ross, M. E. (2001). Reduced susceptibility to ischemic brain injury and N -methyl- d -aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.3.1294
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