The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Molecular clocks
Open accessAbstract
A convenient and precise mass spectrometric method for measurement of the deamidation rates of glutaminyl and asparaginyl residues in peptides and proteins has been developed; the rates of deamidation of 306 asparaginyl sequences in model peptides at pH 7.4, 37.0°C, 0.15 M Tris⋅HCl buffer have been determined; a library of 913 amide-containing peptides for use by other investigators in similar studies has been established; and, by means of simultaneous deamidation rate measurements of rabbit muscle aldolase and appropriate model peptides in the same solutions, the use of this method for quantitative measurement of the relative effects of primary, secondary, tertiary, and quaternary protein structure on deamidation rates has been demonstrated. The measured rates are discussed with respect to the hypothesis that glutaminyl and asparaginyl residues serve, through deamidation, as molecular timers of biological events.
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Citations
Cites
Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide
Merrifield, R. B. (1963) · Journal of the American Chemical Society · doi:10.1021/ja00897a025 · Cited by 7,647
Geiger, T., & Clarke, S. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)75855-4 · Cited by 1,311
Deamidation of Glutaminyl and Asparaginyl Residues in Peptides and Proteins
(1974) · Current Topics in Cellular Regulation · doi:10.1016/b978-0-12-152808-9.50013-4 · Cited by 345
CLARKE, S. (1987) · International Journal of Peptide and Protein Research · doi:10.1111/j.1399-3011.1987.tb03390.x · Cited by 338
Robinson, A. B., McKerrow, J. H., & Cary, P. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.66.3.753 · Cited by 261
Self-citationRates of nonenzymic deamidation of glutaminyl and asparaginyl residues in pentapeptides
Robinson, A. B., Scotchler, J. W., & McKerrow, J. H. (1973) · Journal of the American Chemical Society · doi:10.1021/ja00805a032 · Cited by 137
Self-citationDistribution of glutamine and asparagine residues and their near neighbors in peptides and proteins.
Robinson, A. B., & Robinson, L. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.20.8880 · Cited by 129
Self-citationMultiple Forms of Cytochrome c in the Rat
Flatmark, T., & Sletten, K. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93588-x · Cited by 123
Evolution and the Distribution of Glutaminyl and Asparaginyl Residues in Proteins
Robinson, A. B. (1974) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.71.3.885 · Cited by 119
Self-citationDeamidation In Vivo of an Asparagine Residue of Rabbit Muscle Aldolase
Midelfort, C. F., & Mehler, A. H. (1972) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.69.7.1816 · Cited by 109
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Heterogeneity of Monoclonal Antibodies
Liu, H., Gaza-Bulseco, G., Faldu, D., Chumsae, C., & Sun, J. (2008) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.21180 · Cited by 481
Formulation and delivery issues for monoclonal antibody therapeutics
Daugherty, A. L., & Mrsny, R. J. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.03.011 · Cited by 351
Robinson, N. E., & Robinson, A. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221463198 · Cited by 287
Self-citationRobinson, N. E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082102799 · Cited by 267
Self-citationStructure of the bacterial ribosome at 2 Å resolution
Watson, Z. L., Ward, F. R., Méheust, R., Ad, O., Schepartz, A., Banfield, J. F., & Cate, J. H. (2020) · eLife · doi:10.7554/elife.60482 · Cited by 263
Metadata
- Authors
- Robinson, N. E., & Robinson, A. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-30
- Volume
- 98
- Issue
- 3
- Pages
- 944-949
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2578242640
- Cited by
- 532
- References
- 17
- FWCI
- 8.85
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
