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Visualization of a water-selective pore by electron crystallography in vitreous ice
Open accessAbstract
The water-selective pathway through the aquaporin-1 membrane channel has been visualized by fitting an atomic model to a 3.7-Å resolution three-dimensional density map. This map was determined by analyzing images and electron diffraction patterns of lipid-reconstituted two-dimensional crystals of aquaporin-1 preserved in vitrified buffer in the absence of any additive. The aqueous pathway is characterized by a size-selective pore that is ≈4.0 ± 0.5Å in diameter, spans a length of ≈18Å, and bends by ≈25° as it traverses the bilayer. This narrow pore is connected by wide, funnel-shaped openings at the extracellular and cytoplasmic faces. The size-selective pore is outlined mostly by hydrophobic residues, resulting in a relatively inert pathway conducive to diffusion-limited water flow. The apex of the curved pore is close to the locations of the in-plane pseudo-2-fold symmetry axis that relates the N- and C-terminal halves and the conserved, functionally important N76 and N192 residues.
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Cites
Influence of proline residues on protein conformation
MacArthur, M. W., & Thornton, J. M. (1991) · Journal of Molecular Biology · doi:10.1016/0022-2836(91)90721-h · Cited by 1,189
Cited by
Structural basis of water-specific transport through the AQP1 water channel
Sui, H., Han, B.-G., Lee, J. K., Walian, P., & Jap, B. K. (2001) · Nature · doi:10.1038/414872a · Cited by 1,166
From structure to disease: the evolving tale of aquaporin biology
King, L. S., Kozono, D., & Agre, P. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1469 · Cited by 887
Plant aquaporins: multifunctional water and solute channels with expanding roles
Tyerman, S. D., Niemietz, C. M., & Bramley, H. (2002) · Plant, Cell & Environment · doi:10.1046/j.0016-8025.2001.00791.x · Cited by 638
Aquaporins: water channel proteins of the cell membrane
TAKATA, K. (2004) · Progress in Histochemistry and Cytochemistry · doi:10.1016/j.proghi.2004.03.001 · Cited by 408
Energetics of glycerol conduction through aquaglyceroporin GlpF
Jensen, M. Ø., Park, S., Tajkhorshid, E., & Schulten, K. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.102649299 · Cited by 364
Metadata
- Authors
- Ren, G., Reddy, V. S., Cheng, A., Melnyk, P., & Mitra, A. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2001-01-30
- Volume
- 98
- Issue
- 4
- Pages
- 1398-1403
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2037033695
- Cited by
- 183
- References
- 1
- FWCI
- 5.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ren, G., Reddy, V. S., Cheng, A., Melnyk, P., & Mitra, A. K. (2001). Visualization of a water-selective pore by electron crystallography in vitreous ice. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.98.4.1398
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
