The DOI matches its Crossref record.
Journal of Biological Chemistry
Open accessAbstract
A series of biochemical assays were developed and performed to monitor the molecular events that occur during the Hin-mediated DNA inversion reaction. These events can be divided into five different stages: 1) binding of proteins (Hin, Fis, and HU) to DNA; 2) pairing of Hin-binding sites; 3) invertasome formation; 4) DNA strand cleavage; 6) strand rotation and reli-gation. A series of topoisomers of the wild type DNA substrate plasmid (ranging from fully relaxed mole-cules to those with more than the physiological super-helical density (the physiological superhelical density of pKH336 from Escherichia coli DHlOB ” is-0.072 in this study)) was generated, and the role of negative supercoiling in each step of the inversion reaction was investigated. We found differences in the dependence
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Mohanty, J. G., Nagababu, E., & Rifkind, J. M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00084 · Cited by 595
Microglial cell dysregulation in brain aging and neurodegeneration
von Bernhardi, R., Eugenín-von Bernhardi, L., & Eugenín, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00124 · Cited by 556
SOCS3, a Major Regulator of Infection and Inflammation
Carow, B., & Rottenberg, M. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00058 · Cited by 555
Metadata
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2021-01-04
- ISSN
- 0021-9258 (ISSN-L)
- 1083-351X
- DOI
- 10.1074/jbc
- OpenAlex
- W4288076435
- Cited by
- 3,400
- References
- 0
- Type
- paratext
- Language
- fr
- Open access
- gold
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