SOCS3, a Major Regulator of Infection and Inflammation
Open accessAbstract
In this review, we describe the role of suppressor of cytokine signaling-3 (SOCS3) in modulating the outcome of infections and autoimmune diseases as well as the underlying mechanisms. SOCS3 regulates cytokine or hormone signaling usually preventing, but in some cases aggravating, a variety of diseases. A main role of SOCS3 results from its binding to both the JAK kinase and the cytokine receptor, which results in the inhibition of STAT3 activation. Available data also indicate that SOCS3 can regulate signaling via other STATs than STAT3 and also controls cellular pathways unrelated to STAT activation. SOCS3 might either act directly by hampering JAK activation or by mediating the ubiquitination and subsequent proteasome degradation of the cytokine/growth factor/hormone receptor. Inflammation and infection stimulate SOCS3 expression in different myeloid and lymphoid cell populations as well as in diverse non-hematopoietic cells. The accumulated data suggest a relevant program coordinated by SOCS3 in different cell populations, devoted to the control of immune homeostasis in physiological and pathological conditions such as infection and autoimmunity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HDAC5 promotes the upregulation of Chemokine ligand 2 (CCL2) by inhibiting SOCS3, thereby recruiting CCR2+ macrophages.
“HDAC5 promotes the upregulation of Chemokine ligand 2 (CCL2) by inhibiting SOCS3, thereby recruiting CCR2+ macrophages [147].”
From Targeting KRAS mutant cancers: from druggable therapy to drug resistance (2022) · cites this paper as [147]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED: Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization
Spence, S., Fitzsimons, A., Boyd, C. R., Kessler, J., Fitzgerald, D. C., Elliott, J., Gabhann, J. N., Smith, S., Sica, A., Hams, E., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.013 · Cited by 93 · see citing works
RetractedYaşlı Kadınlarda Üreme Sağlığı
Kokanalı, D., & Engin Üstün, Y. (n.d.) · DergiPark (Istanbul University) · Cited by 170,090 · see citing works
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · cited 1× · see citing works
“Binding to the cytokine activates the kinase function of JAK, a tyrosine kinase that binds to the receptor, which auto-phosphorylates itself, cross-phosphorylates a JAK molecule bound to the accompanying heterodimer chain of the cytokine receptor and also different tyrosine sites on the cytokine receptor (1).”
BackgroundNotch Signaling: Cell Fate Control and Signal Integration in Development
Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909 · see citing works
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405 · see citing works
Ivanov, I. I., McKenzie, B. S., Zhou, L., Tadokoro, C. E., Lepelley, A., Lafaille, J. J., Cua, D. J., & Littman, D. R. (2006) · Cell · doi:10.1016/j.cell.2006.07.035 · Cited by 5,145 · see citing works
Colman (2022) · doi:10.1073/pnas · Cited by 4,370 · see citing works
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · cited 4× · see citing works
“SOCS3 has been also suggested to inhibit IL-12-induced STAT4 activation by direct binding to IL-12Rβ2 (37), the IL-12R subunit that is not shared with the IL-23R.”
BackgroundInfluentialJournal of Biological Chemistry
Kurkinensp, M., CondongT, M. R., Blumberg, B., Barlow, D. P., Quiñones, S., Sausg, J., & Pihlajaniemisyy, T. (2021) · Journal of Biological Chemistry · doi:10.1074/jbc · Cited by 3,409 · see citing works
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201 · see citing works
Drug delivery with carbon nanotubes for in vivo cancer treatment
Liu, Z., Chen, K., Davis, C. R., Sherlock, S. P., Cao, Q., Chen, X. S., & Dai, H. (2008) · PubMed · doi:10.48550/arxiv.0808.2070 · Cited by 2,287 · see citing works
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278 · see citing works
A family of cytokine-inducible inhibitors of signalling
Starr, R., Willson, T. A., Viney, E. M., Murray, L. J. L., Rayner, J. R., Jenkins, B. J., Gonda, T. J., Alexander, W. S., Metcalf, D., Nicola, N. A., et al. (1997) · Nature · doi:10.1038/43206 · Cited by 2,066 · see citing works
SOCS proteins, cytokine signalling and immune regulation
Yoshimura, A., Naka, T., & Kubo, M. (2007) · Nature Reviews Immunology · doi:10.1038/nri2093 · Cited by 1,580 · see citing works
The JAK-STAT Pathway at Twenty
Stark, G. R., & Darnell, J. E., Jr. (2012) · Immunity · doi:10.1016/j.immuni.2012.03.013 · Cited by 1,523 · see citing works
A new protein containing an SH2 domain that inhibits JAK kinases
Endo, T. A., Masuhara, M., Yokouchi, M., Suzuki, R., Sakamoto, H., Mitsui, K., Matsumoto, A., Tanimura, S., Ohtsubo, M., Misawa, H., et al. (1997) · Nature · doi:10.1038/43213 · Cited by 1,408 · see citing works
STATs: Signal Transducers and Activators of Transcription
Ihle, J. N. (1996) · Cell · doi:10.1016/s0092-8674(00)81277-5 · Cited by 1,381 · see citing works
Regulation of JAK–STAT signalling in the immune system
Shuai, K., & Liu, B. (2003) · Nature reviews. Immunology · doi:10.1038/nri1226 · Cited by 1,379 · see citing works
Structure and function of a new STAT-induced STAT inhibitor
Naka, T., Narazaki, M., Hirata, M., Matsumoto, T., Minamoto, S., Aono, A., Nishimoto, N., Kajita, T., Taga, T., Yoshizaki, K., et al. (1997) · Nature · doi:10.1038/43219 · Cited by 1,287 · see citing works
Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
Milner, J. D., Brenchley, J. M., Laurence, A., Freeman, A. F., Hill, B. J., Elias, K. M., Kanno, Y., Spalding, C., Elloumi, H. Z., Paulson, M. L., et al. (2008) · Nature · doi:10.1038/nature06764 · Cited by 1,157 · see citing works
Identification of SOCS-3 as a Potential Mediator of Central Leptin Resistance
Bjørbæk, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E., & Flier, J. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80062-3 · Cited by 1,014 · see citing works
Function of Mitochondrial Stat3 in Cellular Respiration
Wegrzyn, J., Potla, R., Chwae, Y.-J., Sepuri, N. B. V., Zhang, Q., Koeck, T., Derecka, M., Szczepanek, K., Szelag, M., Gornicka, A., et al. (2009) · Science · doi:10.1126/science.1164551 · Cited by 1,014 · see citing works
Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis
Balthasar, N., Coppari, R., McMinn, J., Liu, S. M., Lee, C. E., Tang, V., Kenny, C. D., McGovern, R. A., Chua, S. C., Elmquist, J. K., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.004 · Cited by 935 · see citing works
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
Rui, L., Yuan, M., Frantz, D., Shoelson, S., & White, M. F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.c200444200 · Cited by 904 · see citing works
SOCS3 negatively regulates IL-6 signaling in vivo
Croker, B. A., Krebs, D. L., Zhang, J.-G., Wormald, S., Willson, T. A., Stanley, E. G., Robb, L., Greenhalgh, C. J., Förster, I., Clausen, B. E., et al. (2003) · Nature Immunology · doi:10.1038/ni931 · Cited by 840 · see citing works
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology · doi:10.1038/ni938 · Cited by 771 · see citing works
Inhibition of Stat1-mediated gene activation by PIAS1
Liu, B., Liao, J., Rao, X., Kushner, S. A., Chung, C. D., Chang, D. D., & Shuai, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.18.10626 · Cited by 765 · see citing works
Yoshimura, A., Ohkubo, T., Kiguchi, T., Jenkins, N. A., Gilbert, D. J., Copeland, N. G., Hara, T., & Miyajima, A. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07281.x · Cited by 751 · see citing works
Twenty proteins containing a C-terminal SOCS box form five structural classes
Hilton, D. J., Richardson, R. T., Alexander, W. S., Viney, E. M., Willson, T. A., Sprigg, N. S., Starr, R., Nicholson, S. E., Metcalf, D., & Nicola, N. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.114 · Cited by 728 · see citing works
Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., Ohtsuka, S., Imaizumi, T., Matsuda, T., Ihle, J. N., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1309 · Cited by 719 · see citing works
Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells
Chen, Z. J., Laurence, A. D. J., Kanno, Y., Pacher-Zavisin, M. C., Zhu, B., Tato, C. M., Yoshimura, A., Hennighausen, L. G., & O’Shea, J. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600666103 · Cited by 652 · see citing works
Mori, H., Hanada, R., Hanada, T., Aki, D., Mashima, R., Nishinakamura, H., Torisu, T., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Nature Medicine · doi:10.1038/nm1071 · Cited by 651 · see citing works
Yoshida, K., Taga, T., Saito, M., Suematsu, S., Kumanogoh, A., Tanaka, T., Fujiwara, H., Hirata, M., Yamagami, T., Nakahata, T., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.1.407 · Cited by 634 · see citing works
Zhang, J., Farley, A., Nicholson, S. E., Willson, T. A., Zugaro, L. M., Simpson, R. J., Moritz, R. L., Cary, D., Richardson, R. T., Hausmann, G., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.2071 · Cited by 626 · see citing works
Senn, J. J., Klover, P. J., Nowak, I. A., Zimmers, T. A., Koniaris, L. G., Furlanetto, R. W., & Mooney, R. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210689200 · Cited by 620 · see citing works
Suppressors of cytokine signaling and immunity
Kubo, M., Hanada, T., & Yoshimura, A. (2003) · Nature Immunology · doi:10.1038/ni1012 · Cited by 614 · see citing works
Ogura, H., Murakami, M., Okuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., & Hirano, T. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.018 · Cited by 564 · see citing works
SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985
Bjørbæk, C., Lavery, H. J., Bates, S. H., Olson, R. K., Davis, S. M., Flier, J. S., & Myers, M. G. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m007577200 · Cited by 537 · see citing works
Kawaguchi, T., Yoshida, T., Harada, M., Hisamoto, T., Nagao, Y., Ide, T., Taniguchi, E., Kumemura, H., Hanada, S., Maeyama, M., et al. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63408-6 · Cited by 534 · see citing works
Gigantism in mice lacking suppressor of cytokine signalling-2
Metcalf, D., Greenhalgh, C. J., Viney, E. M., Willson, T. A., Starr, R., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (2000) · Nature · doi:10.1038/35016611 · Cited by 490 · see citing works
Howard, J. K., Cave, B. J., Oksanen, L. J., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Nature Medicine · doi:10.1038/nm1072 · Cited by 490 · see citing works
Wang, Y., He, F., Feng, F., Liu, X., Dong, G., Qin, H., Hu, X., Zheng, M., Liang, L., Feng, L., et al. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-0269 · Cited by 478 · see citing works
Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B., Waring, P., Clay, F. J., Malki, S., Alderman, B. M., Grail, D., Hollande, F., et al. (2002) · Nature Medicine · doi:10.1038/nm763 · Cited by 474 · see citing works
Cis3/Socs3/Ssi3 Plays a Negative Regulatory Role in Stat3 Activation and Intestinal Inflammation
Suzuki, A., Hanada, T., Mitsuyama, K., Yoshida, T., Kamizono, S., Hoshino, T., Kubo, M., Yamashita, A., Okabe, M., Takeda, K., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.4.471 · Cited by 473 · see citing works
SOCS-3 Is an Insulin-induced Negative Regulator of Insulin Signaling
Emanuelli, B., Peraldi, P., Filloux, C., Sawka‐Verhelle, D., Hilton, D. J., & OBBERGHEN, E. V. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.21.15985 · Cited by 468 · see citing works
Nicholson, S. E., De Souza, D., Fabri, L. J., Corbin, J., Willson, T. A., Zhang, J.-G., Silva, A., Asimakis, M., Farley, A., Nash, A. D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100135197 · Cited by 456 · see citing works
SOCS3 Deficiency Promotes M1 Macrophage Polarization and Inflammation
Qin, H., Holdbrooks, A. T., Liu, Y., Reynolds, S. L., Yanagisawa, L. L., & Benveniste, E. N. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201168 · Cited by 454 · see citing works
Regulation of gene-activation pathways by PIAS proteins in the immune system
Shuai, K., & Liu, B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1667 · Cited by 447 · see citing works
SOCS3 regulates the plasticity of gp130 signaling
Lang, R., Pauleau, A.-L., Parganas, E., Takahashi, Y., Mages, J., Ihle, J. N., Rutschman, R., & Murray, P. J. (2003) · Nature Immunology · doi:10.1038/ni932 · Cited by 439 · see citing works
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
Starr, R., Metcalf, D., Elefanty, A. G., Brysha, M., Willson, T. A., Nicola, N. A., Hilton, D. J., & Alexander, W. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.24.14395 · Cited by 421 · see citing works
Cui, W., Liu, Y., Weinstein, J. S., Craft, J., & Kaech, S. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.017 · Cited by 410 · see citing works
Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis
Taleb, S., Romain, M., Ramkhelawon, B., Uyttenhove, C., Pasterkamp, G., Herbin, O., Esposito, B., Pérez, N., Yasukawa, H., Snick, J. V., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090545 · Cited by 409 · see citing works
Sasaki, A., Yasukawa, H., Suzuki, A., Kamizono, S., Syoda, T., Kinjyo, I., Sasaki, M., Johnston, J. A., & Yoshimura, A. (1999) · Genes to Cells · doi:10.1046/j.1365-2443.1999.00263.x · Cited by 398 · see citing works
Shouda, T., Yoshida, T., Hanada, T., Wakioka, T., Oishi, M., Miyoshi, K., Komiya, S., Kosai, K.-I., Hanakawa, Y., Hashimoto, K., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13568 · Cited by 394 · see citing works
Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C., & Schaper, F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.17.12848 · Cited by 388 · see citing works
SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis
Marine, J.-C., McKay, C., Wang, D., Topham, D. J., Parganas, E., Nakajima, H., Pendeville, H., Yasukawa, H., Sasaki, A., Yoshimura, A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80049-5 · Cited by 372 · see citing works
Escary, J.-L., Perreau, J., Dumènil, D., Ezine, S., & Brûlet, P. (1993) · Nature · doi:10.1038/363361a0 · Cited by 363 · see citing works
SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
Seki, Y.-I., Inoue, H., Nagata, N., Hayashi, K., Fukuyama, S., Matsumoto, K., Komine, O., Hamano, S., Himeno, K., Inagaki‐Ohara, K., et al. (2003) · Nature Medicine · doi:10.1038/nm896 · Cited by 361 · see citing works
Ernst, M., Najdovska, M., Grail, D., Lundgren–May, T., Büchert, M., Tye, H., Matthews, V. B., Armes, J. E., Bhathal, P. S., Hughes, N. R., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34944 · Cited by 346 · see citing works
STAT3 activation in response to IL-6 is prolonged by the binding of IL-6 receptor to EGF receptor
Wang, Y., van Boxel-Dezaire, A. H. H., Cheon, H., Yang, J., & Stark, G. R. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1315862110 · Cited by 327 · see citing works
Protein tyrosine phosphatases in the JAK/STAT pathway
Xu, D. (2008) · Frontiers in bioscience · doi:10.2741/3051 · Cited by 309 · see citing works
IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology
Pellegrini, M., Calzascia, T., Toe, J. G., Preston, S., Lin, A. E., Elford, A. R., Shahinian, A., Lang, P. A., Lang, K. S., Morre, M., et al. (2011) · Cell · doi:10.1016/j.cell.2011.01.011 · Cited by 309 · see citing works
Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., et al. (2005) · Nature Medicine · doi:10.1038/nm1282 · Cited by 308 · see citing works
Kershaw, N. J., Murphy, J. M., Liau, N. P. D., Varghese, L. N., Laktyushin, A., Whitlock, E. L., Lucet, I. S., Nicola, N. A., & Babon, J. J. (2013) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2519 · Cited by 301 · see citing works
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
Roberts, A. W., Robb, L., Rakar, S., Hartley, L., Cluse, L., Nicola, N. A., Metcalf, D., Hilton, D. J., & Alexander, W. S. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161271798 · Cited by 300 · see citing works
Canonical and non-canonical JAK–STAT signaling
Li, W. X. (2008) · Trends in Cell Biology · doi:10.1016/j.tcb.2008.08.008 · Cited by 290 · see citing works
SOCS3 Is a Critical Physiological Negative Regulator of G-CSF Signaling and Emergency Granulopoiesis
Croker, B. A., Metcalf, D., Robb, L., Wei, W., Mifsud, S., DiRago, L., Cluse, L. A., Sutherland, K. D., Hartley, L., Williams, E., et al. (2004) · Immunity · doi:10.1016/s1074-7613(04)00022-6 · Cited by 285 · see citing works
Ohtani, T., Ishihara, K., Atsumi, T., Nishida, K., Kaneko, Y., Miyata, T., Itoh, S., Narimatsu, M., Maeda, H., Fukada, T., et al. (2000) · Immunity · doi:10.1016/s1074-7613(00)80162-4 · Cited by 284 · see citing works
Babon, J. J., Kershaw, N. J., Murphy, J. M., Varghese, L. N., Laktyushin, A., Young, S. N., Lucet, I. S., Norton, R. S., & Nicola, N. A. (2012) · Immunity · doi:10.1016/j.immuni.2011.12.015 · Cited by 279 · see citing works
Influenza A Virus Inhibits Type I IFN Signaling via NF-κB-Dependent Induction of SOCS-3 Expression
Pauli, E.-K., Schmolke, M., Wolff, T., Viemann, D., Roth, J., Bode, J. G., & Ludwig, S. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000196 · Cited by 274 · see citing works
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis
Jo, D., Liu, D., Yao, S., Collins, R. D., & Hawiger, J. (2005) · Nature Medicine · doi:10.1038/nm1269 · Cited by 271 · see citing works
Nishihara, M., Ogura, H., Ueda, N., Tsuruoka, M., Kitabayashi, C., Tsuji, F., Aono, H., Ishihara, K., Huseby, E., Betz, U. A. K., et al. (2007) · International Immunology · doi:10.1093/intimm/dxm045 · Cited by 268 · see citing works
Qin, H., Yeh, W.-I., Sarno, P. D., Holdbrooks, A. T., Liu, Y., Muldowney, M., Reynolds, S. L., Yanagisawa, L. L., Fox, T. H., Park, K., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117218109 · Cited by 266 · see citing works
Leaman, D. W., Pisharody, S., Flickinger, T., Commane, M., Schlessinger, J., Kerr, I. M., Levy, D., & Stark, G. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.1.369 · Cited by 249 · see citing works
Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-β1 production
Ogata, H., Chinen, T., Yoshida, T., Kinjyo, I., Takaesu, G., Shiraishi, H., Iida, M., Kobayashi, T., & Yoshimura, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209281 · Cited by 246 · see citing works
Cornejo, I., Andrini, O., Niemeyer, M. I., Marabolí, V., González-Nilo, F. D., Teulon, J., Sepúlveda, F. V., & Cid, L. P. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004402 · Cited by 245 · see citing works
Alvarez, J. V., Greulich, H. E., Sellers, W. R., Meyerson, M. M., & Frank, D. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3757 · Cited by 241 · see citing works
Saunders, B., Frank, A., Orme, I., & Cooper, A. (2000) · Infection and Immunity · doi:10.1128/iai.68.6.3322-3326.2000 · Cited by 240 · see citing works
Egwuagu, C. E., Yu, C., Zhang, M., Mahdi, R. M., Kim, S. J., & Gery, I. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3181 · Cited by 239 · see citing works
TGF-β Promotes Th17 Cell Development through Inhibition of SOCS3
Qin, H., Wang, L., Feng, T., Elson, C. O., Niyongere, S., Lee, S. J., Reynolds, S. L., Weaver, C. T., Roarty, K. P., Serra, R. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0801986 · Cited by 238 · see citing works
Han, W., & Lo, H. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.011 · Cited by 238 · see citing works
Yamamoto, M., Standley, D. M., Takashima, S., Saiga, H., Okuyama, M., Kayama, H., Kubo, E., Ito, H., Takaura, M., Matsuda, T., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091703 · Cited by 236 · see citing works
SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130
Lehmann, U., Schmitz, J., Weissenbach, M., Sobota, R. M., Hörtner, M., Friederichs, K., Behrmann, I., Tsiaris, W., Sasaki, A., Schneider-Mergener, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210552200 · Cited by 236 · see citing works
Kinjyo, I., Inoue, H., Hamano, S., Fukuyama, S., Yoshimura, T., Koga, K., Takaki, H., Himeno, K., Takaesu, G., Kobayashi, T., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20052333 · Cited by 225 · see citing works
Suppressor of Cytokine Signaling 3 Is a Physiological Regulator of Adipocyte Insulin Signaling
Shi, H., Tzameli, I., Bjørbæk, C., & Flier, J. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403886200 · Cited by 223 · see citing works
Wong, P. K. K. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25660 · Cited by 215 · see citing works
Orabona, C., Pallotta, M. T., Volpi, C., Fallarino, F., Vacca, C., Bianchi, R., Belladonna, M. L., Fioretti, M. C., Grohmann, U., & Puccetti, P. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810278105 · Cited by 205 · see citing works
STAT3 inhibition, a novel approach to enhancing targeted therapy in human cancers
Wang, X., Crowe, P. J., Goldstein, D., & Yang, J. (2012) · International Journal of Oncology · doi:10.3892/ijo.2012.1568 · Cited by 202 · see citing works
Gisterå, A., Robertson, A.-K. L., Andersson, J., Ketelhuth, D. F. J., Овчинникова, О. А., Nilsson, S. K., Lundberg, A. M., Li, M. O., Flavell, R. A., & Hansson, G. K. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006133 · Cited by 195 · see citing works
Tanaka, K., Ichiyama, K., Hashimoto, M., Yoshida, H., Takimoto, T., Takaesu, G., Torisu, T., Hanada, T., Yasukawa, H., Fukuyama, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3746 · Cited by 182 · see citing works
Mechanisms of chronic JAK-STAT3-SOCS3 signaling in obesity
Wunderlich, C. M., Hövelmeyer, N., & Wunderlich, F. T. (2013) · JAK-STAT · doi:10.4161/jkst.23878 · Cited by 176 · see citing works
Braun, D. A., Fribourg, M., & Sealfon, S. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386573 · Cited by 168 · cited 2× · see citing works
“as the putative cause of SOCS3’s effect: the suppressive effect of IL-6 signaling on TNF and IL-12 secretion in absence of SOCS3 was explained to be due to a sustained STAT3 activation (101, 102).”
BackgroundCao, W., Yang, Y., Wang, Z., Liu, A., Fang, L., Wu, F., Hong, J., Shi, Y., Leung, S., Dong, C., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.06.011 · Cited by 166 · see citing works
Persico, M., Capasso, M., Persico, E., Svelto, M., Russo, R., Spano, D., Crocè, L. S., Mura, V. L., Moschella, F., Masutti, F., et al. (2007) · Hepatology · doi:10.1002/hep.21782 · Cited by 164 · see citing works
Minamoto, S., Ikegame, K., Ueno, K., Narazaki, M., Naka, T., Yamamoto, H., Matsumoto, T., Saito, H., Hosoe, S., & Kishimoto, T. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7080 · Cited by 164 · see citing works
Babon, J. J., McManus, E. J., Yao, S., DeSouza, D. P., Mielke, L. A., Sprigg, N. S., Willson, T. A., Hilton, D. J., Nicola, N. A., Baca, M., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.024 · Cited by 163 · see citing works
Liu, Y., Stewart, K. N., Bishop, E., Marek, C. J., Kluth, D., Rees, A. J., & Wilson, H. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6270 · Cited by 163 · see citing works
Pothlichet, J., Chignard, M., & Si‐Tahar, M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2034 · Cited by 162 · see citing works
Frobøse, H., Rønn, S. G., Heding, P. E., Mendoza, H., Cohen, P., Mandrup-Poulsen, T. R., & Billestrup, N. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0301 · Cited by 161 · see citing works
Nguyen-Jackson, H., Panopoulos, A. D., Zhang, H., Li, H. S., & Watowich, S. S. (2010) · Blood · doi:10.1182/blood-2009-08-240317 · Cited by 151 · see citing works
Babon, J. J., Sabo, J. K., Zhang, J., Nicola, N. A., & Norton, R. S. (2009) · Journal of Molecular Biology · doi:10.1016/j.jmb.2009.01.024 · Cited by 143 · see citing works
Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor
Eyckerman, S., Broekaert, D., Verhee, A., Vandekerckhove, J. S., & Tavernier, J. H. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02205-5 · Cited by 142 · see citing works
Li, Y., Chu, N., Rostami, A. M., & Zhang, G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1679 · Cited by 141 · see citing works
Schneider, R., Yaneva, T., Beauseigle, D., El‐Khoury, L., & Arbour, N. (2010) · European Journal of Immunology · doi:10.1002/eji.201040804 · Cited by 139 · see citing works
IL-27 Suppresses CD28-Medicated IL-2 Production through Suppressor of Cytokine Signaling 3
Owaki, T., Asakawa, M., Kamiya, S., Takeda, K., Fukai, F., Mizuguchi, J., & Yoshimoto, T. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.5.2773 · Cited by 136 · see citing works
Miao, T., Wu, D., Zhang, Y., Bo, X., Subang, M. C., Wang, P., & Richardson, P. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2160-06.2006 · Cited by 131 · see citing works
Yamamoto, K., Yamaguchi, M., Miyasaka, N., & Miura, O. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.09.140 · Cited by 131 · see citing works
Hörtner, M., Nielsch, U., Mayr, L. M., Johnston, J. A., Heinrich, P. C., & Haan, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1219 · Cited by 128 · see citing works
Wormald, S., Zhang, J.-G., Krebs, D. L., Mielke, L. A., Silver, J., Alexander, W. S., Speed, T. P., Nicola, N. A., & Hilton, D. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509595200 · Cited by 123 · cited 2× · see citing works
“Interestingly, after the initial phosphorylation of STAT3 in response to IL-6 followed by a subsequent inhibition by SOCS3, a second wave of activation leads to the re-phosphorylation of STAT3 (101).”
BackgroundSuppressors of Cytokine Signaling Modulate JAK/STAT-Mediated Cell Responses During Atherosclerosis
Ortiz-Muñoz, G., Martı́n-Ventura, J. L., Hernández-Vargas, P., Mallavia, B., López-Parra, V., López‐Franco, Ó., Muñoz‐García, B., Fernández‐Vizarra, P., Ortega, L. M., Egido, J., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.173781 · Cited by 123 · see citing works
The biology and mechanism of action of Suppressor of Cytokine Signaling 3 (SOCS3)
Babon, J., & Nicola, N. (2012) · Growth Factors · doi:10.3109/08977194.2012.687375 · Cited by 121 · see citing works
Kimura, A., Kinjyo, I., Matsumura, Y., Mori, H., Mashima, R., Harada, M., Chien, K. R., Yasukawa, H., & Yoshimura, A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c300496200 · Cited by 119 · see citing works
Ozaki, A., Seki, Y.-I., Fukushima, A., & Kubo, M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.8.5489 · Cited by 109 · see citing works
Matsumura, Y., Kobayashi, T., Ichiyama, K., Yoshida, R., Hashimoto, M., Takimoto, T., Tanaka, K., Chinen, T., Shichita, T., Wyss‐Coray, T., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2170 · Cited by 107 · see citing works
Akhtar, L. N., Qin, H., Muldowney, M., Yanagisawa, L. L., Kutsch, O., Clements, J. E., & Benveniste, E. N. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903563 · Cited by 99 · see citing works
Auernhammer, C. J., Chesnokova, V., Bousquet, C., & Melmed, S. K. (1998) · Molecular Endocrinology · doi:10.1210/mend.12.7.0140 · Cited by 96 · see citing works
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover
Orr, S. J., Morgan, N. M., Elliott, J., Burrows, J. F., Scott, C. J., McVicar, D. W., & Johnston, J. A. (2006) · Blood · doi:10.1182/blood-2006-05-023556 · Cited by 94 · see citing works
Yeddula, N., & Balaji, K. N. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709960200 · Cited by 93 · see citing works
Nair, S., Pandey, A. D., & Mukhopadhyay, S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000773 · Cited by 92 · see citing works
Suppressor of cytokine signaling 3 controls lysosomal routing of G‐CSF receptor
Irandoust, M. I., Aarts, L. H. J., Roovers, O., Gits, J., Erkeland, S. J., & Touw, I. P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601640 · Cited by 89 · see citing works
Hörtner, M., Nielsch, U., Mayr, L. M., Heinrich, P. C., & Haan, S. (2002) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2002.02916.x · Cited by 88 · see citing works
Orabona, C., Belladonna, M. L., Vacca, C., Bianchi, R., Fallarino, F., Volpi, C., Gizzi, S., Fioretti, M. C., Grohmann, U., & Puccetti, P. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.11.6582 · Cited by 87 · see citing works
Persico, M., Capasso, M., Russo, R., Persico, E., Crocè, L. S., Tiribelli, C., & Iolascon, A. (2007) · Gut · doi:10.1136/gut.2007.129478 · Cited by 87 · see citing works
McKay, B. R., Ogborn, D. I., Baker, J. M., Toth, K., Tarnopolsky, M. A., & Parise, G. (2013) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00305.2012 · Cited by 83 · see citing works
A Critical Role for SOCS3 in Innate Resistance to Toxoplasma gondii
Whitmarsh, R. J., Gray, C. M., Gregg, B., Christian, D. A., May, M. J., Murray, P. J., & Hunter, C. A. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.07.009 · Cited by 78 · see citing works
Emery, B., Cate, H. S., Marriott, M., Merson, T., Binder, M. D., Snell, C., Soo, P. Y., Murray, S., Croker, B., Zhang, J.-G., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602574103 · Cited by 78 · see citing works
Gisterå, A., Robertson, A.-K., Andersson, J., Ketelhuth, D. F. J., Овчинникова, О. А., Nilsson, S. K., Lundberg, A. M., Li, M. O., Flavell, R. A., & Hansson, G. K. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.05.233 · Cited by 78 · see citing works
Jiang, C.-T., Kim, J.-H., Li, F., Qu, A.-J., Gavrilova, O., Shah, Y., & Gonzalez, F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.426338 · Cited by 73 · see citing works
Boyle, K., Egan, P. J., Rakar, S., Willson, T. A., Wicks, I. P., Metcalf, D., Hilton, D. J., Nicola, N. A., Alexander, W. S., Roberts, A. W., et al. (2007) · Blood · doi:10.1182/blood-2007-03-079178 · Cited by 72 · see citing works
Yoshikawa, T., Takata, A., Otsuka, M., Kishikawa, T., Kojima, K., Yoshida, H., & Koike, K. (2012) · Scientific Reports · doi:10.1038/srep00637 · Cited by 72 · see citing works
Oba, T., Yasukawa, H., Hoshijima, M., Sasaki, K., Futamata, N., Fukui, D., Mawatari, K., Nagata, T., Kyogoku, S., Ohshima, H., et al. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.10.887 · Cited by 70 · see citing works
Yokota, S., Yokosawa, N., Okabayashi, T., Suzutani, T., & Fujii, N. (2005) · Virology · doi:10.1016/j.virol.2005.04.028 · Cited by 67 · see citing works
Sodenkamp, J., Waetzig, G. H., Scheller, J., Seegert, D., Grötzinger, J., Rose‐John, S., Ehlers, S., & Hölscher, C. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.01.015 · Cited by 66 · see citing works
SOCS3 Targets Siglec 7 for Proteasomal Degradation and Blocks Siglec 7-mediated Responses
Orr, S. J., Morgan, N. M., Buick, R. J., Boyd, C. R., Elliott, J., Burrows, J. F., Jefferies, C. A., Crocker, P. R., & Johnston, J. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600216200 · Cited by 64 · see citing works
Brender, C., Tannahill, G. M., Jenkins, B. J., Fletcher, J. G., Columbus, R., Saris, C. J. M., Ernst, M., Nicola, N. A., Hilton, D. J., Alexander, W. S., et al. (2007) · Blood · doi:10.1182/blood-2006-08-041541 · Cited by 64 · see citing works
Structural Basis for Phosphotyrosine Recognition by Suppressor of Cytokine Signaling-3
Bergamin, E., Wu, J., & Hubbard, S. R. (2006) · Structure · doi:10.1016/j.str.2006.06.011 · Cited by 60 · see citing works
Caruso, R., Stolfi, C., Sarra, M., Rizzo, A., Fantini, M. C., Pallone, F., MacDonald, T. T., & Monteleone, G. (2009) · Blood · doi:10.1182/blood-2008-08-172767 · Cited by 60 · see citing works
Carow, B., Ye, X. Q., Gavier‐Widén, D., Bhuju, S., Oehlmann, W., Singh, M., Sköld, M., Ignatowicz, L., Yoshimura, A., Wigzell, H., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.238287 · Cited by 60 · see citing works
Self-citationKim, K., Kim, K. H., & Cheong, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008649 · Cited by 59 · see citing works
Masood, K. I., Rottenberg, M. E., Salahuddin, N., Irfan, M., Rao, N. A., Carow, B., Islam, M., Hussain, R., & Hasan, Z. (2013) · BMC Infectious Diseases · doi:10.1186/1471-2334-13-13 · Cited by 58 · see citing works
Self-citationLee, J. E., Yang, Y., Liang, F., Gough, D. J., Levy, D. E., & Sehgal, P. B. (2011) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00379.2011 · Cited by 58 · see citing works
Kim, K., Lin, W., Tai, A. W., Shao, R., Weinberg, E. M., Borges, C. B. D. S., Bhan, A. K., Zheng, H., Kamegaya, Y., & Chung, R. T. (2009) · Journal of Hepatology · doi:10.1016/j.jhep.2008.12.021 · Cited by 57 · see citing works
Romain, M., Taleb, S., Dalloz, M., Ponnuswamy, P., Esposito, B., Pérez, N., Wang, Y., Yoshimura, A., Tedgui, A., & Mallat, Z. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.300516 · Cited by 52 · see citing works
Michaud, F., Coulombe, F., Gaudreault, É., Paquet‐Bouchard, C., Rola‐Pleszczynski, M., & Gosselin, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011908 · Cited by 51 · see citing works
Funaoka, Y., Sakamoto, N., Suda, G., Itsui, Y., Nakagawa, M., Kakinuma, S., Watanabe, T., Mishima, K., Ueyama, M., Onozuka, I., et al. (2011) · Journal of Virology · doi:10.1128/jvi.02583-10 · Cited by 51 · see citing works
Elevated Expression and Genetic Association Links the SOCS3 Gene to Atopic Dermatitis
Ekelund, E., Sääf, A. M., Tengvall-Linder, M., Melén, E., Link, J., Barker, J. N., Reynolds, N. J., Meggitt, S. J., Kere, J., Wahlgren, C., et al. (2006) · The American Journal of Human Genetics · doi:10.1086/504272 · Cited by 51 · see citing works
IL‐6 promotes acute and chronic inflammatory disease in the absence of SOCS3
Croker, B. A., Kiu, H., Pellegrini, M., Toe, J. G., Preston, S., Metcalf, D., O’Donnell, J. A., Cengia, L. H., McArthur, K., Nicola, N. A., et al. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.29 · Cited by 51 · see citing works
Palanivel, R., Fullerton, M. D., Galić, S., Honeyman, J. E., Hewitt, K., Jørgensen, S. B., & Steinberg, G. R. (2012) · Diabetologia · doi:10.1007/s00125-012-2665-3 · Cited by 51 · see citing works
Robb, L. G., Boyle, K., Rakar, S., Hartley, L., Lochland, J., Roberts, A. W., Alexander, W. S., & Metcalf, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508023102 · Cited by 49 · see citing works
Hamanaka, I., Saito, Y., Yasukawa, H., Kishimoto, I., Kuwahara, K., Miyamoto, Y., Harada, M., Ogawa, E., Kajiyama, N., Takahashi, N., et al. (2001) · Circulation Research · doi:10.1161/hh0701.088512 · Cited by 49 · see citing works
SOCS3 promotes TLR4 response in macrophages by feedback inhibiting TGF-β1/Smad3 signaling
Liu, X., Zhang, Y., Yu, Y., Yang, X. Y., & Cao, X. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.08.018 · Cited by 49 · see citing works
Zhang, Z., Liu, Q., Che, Y., Yuan, X., Dai, L., Zeng, B., Jiao, G., Zhang, Y., Wu, X., Yu, Y., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2970 · Cited by 49 · see citing works
Magrangeas, F., Boisteau, O., DENIS, S., Jacques, Y., & Minvielle, S. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530223 · Cited by 48 · see citing works
TGF-β-induced SOCS3 expression augments TNF-α-induced osteoclast formation
Lovibond, A. C., Haque, S. J., Chambers, T. J., & Fox, S. W. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2003.08.068 · Cited by 47 · see citing works
Hashimoto, K., Ishibashi, K., Ishioka, K., Zhao, D., Sato, M., Ohara, S., Abe, Y., Kawasaki, Y., Sato, Y., Yokota, S., et al. (2009) · Virology · doi:10.1016/j.virol.2009.06.026 · Cited by 46 · see citing works
Suppressors of Cytokine Signaling 2 and 3 Diametrically Control Macrophage Polarization
Spence, S., Fitzsimons, A., Boyd, C. R., Kessler, J., Fitzgerald, D. C., Elliott, J., Gabhann, J. N., Smith, S., Sica, A., Hams, E., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.016 · Cited by 46 · see citing works
Yan, C., Ward, P. A., Wang, X., & Gao, H. (2013) · The FASEB Journal · doi:10.1096/fj.12-225797 · Cited by 45 · see citing works
Shouda, T., Yoshida, T., Hanada, T., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113568 · Cited by 44 · see citing works
IL-6 Mediates the Susceptibility of Glycoprotein 130 Hypermorphs to Toxoplasma gondii
Silver, J. S., Stumhofer, J. S., Passos, S., Ernst, M., & Hunter, C. A. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1004144 · Cited by 42 · see citing works
Carow, B., Reuschl, A., Gavier‐Widén, D., Jenkins, B. J., Ernst, M., Yoshimura, A., Chambers, B. J., & Rottenberg, M. E. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003442 · Cited by 41 · see citing works
Self-citationSOCS3 regulates graft-versus-host disease
Hill, G. R., Kuns, R. D., Raffelt, N. C., Don, A. L. J., Olver, S. D., Markey, K. A., Wilson, Y. A., Tocker, J. E., Alexander, W. S., Clouston, A. D., et al. (2010) · Blood · doi:10.1182/blood-2009-12-259598 · Cited by 40 · see citing works
Bixler, S. L., Utay, N. S., Douek, D. C., & Mattapallil, J. J. (2013) · Journal of Virology · doi:10.1128/jvi.00600-13 · Cited by 37 · see citing works
Croker, B. A., Mielke, L. A., Wormald, S., Metcalf, D., Kiu, H., Alexander, W. S., Hilton, D. J., & Roberts, A. W. (2008) · Experimental Hematology · doi:10.1016/j.exphem.2008.02.008 · Cited by 33 · see citing works
Moriwaki, A., Inoue, H., Nakano, T., Matsunaga, Y., Matsuno, Y., Matsumoto, T., Fukuyama, S., Kan‐o, K., Matsumoto, K., Tsuda, M., et al. (2010) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2009-0051oc · Cited by 33 · see citing works
Fletcher, T. C., DiGiandomenico, A., & Hawiger, J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.095216 · Cited by 31 · see citing works
Veenbergen, S., Bennink, M. B., de Hooge, A. S. K., Arntz, O. J., Smeets, R. L., van den Berg, W. B., & van de Loo, F. A. J. (2008) · Arthritis & Rheumatism · doi:10.1002/art.24072 · Cited by 30 · see citing works
Overexpression of the suppressor of cytokine signalling 3 (SOCS3) in severe atopic dermatitis.
Horiuchi, Y., Bae, S.-J., & Katayama, I. (2006) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2005.01979.x · Cited by 25 · see citing works
Auernhammer, C. J. (1998) · Molecular Endocrinology · doi:10.1210/me.12.7.954 · Cited by 22
gp130 on macrophages/granulocytes modulates inflammation during experimental tuberculosis
Sodenkamp, J., Behrends, J., Förster, I., Müller, W., Ehlers, S., & Hölscher, C. (2010) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2010.10.010 · Cited by 18 · see citing works
Nakaya, M., Hamano, S., Kawasumi, M., Yoshida, H., Yoshimura, A., & Kobayashi, T. (2011) · International Immunology · doi:10.1093/intimm/dxq472 · Cited by 17 · see citing works
Guidelines for the management of Irritable Bowel Syndrome
Spiller, R., Aziz, Q., Creed, F. H., Emmanuel, A. V., Houghton, L. A., Hungin, A. P., Jones, R., Kumar, D., Rubin, G. P., Trudgill, N., et al. (2007) · Durham Research Online (Durham University) · doi:10.1136/gut.2007 · Cited by 17 · see citing works
Gu, H., Liu, L., Ma, S., Liu, Y., Ren, Y., Zhai, L., Yu, F., An, L., & Yang, J. (2009) · Endocrine · doi:10.1007/s12020-009-9253-4 · Cited by 15 · see citing works
Erratum To: Suppressor of cytokine signaling 3 controls lysosomal routing of G‐CSF receptor
Irandoust, M. I., Aarts, L. H. J., Roovers, O., Gits, J., Erkeland, S. J., & Touw, I. P. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601709 · Cited by 13 · see citing works
Levy, D. E., & Marié, I. J. (2012) · Immunity · doi:10.1016/j.immuni.2012.04.003 · Cited by 12 · see citing works
Emery, B., Butzkueven, H., Snell, C. E., Binder, M. D., & Kilpatrick, T. J. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.022 · Cited by 11 · see citing works
Perturbed thymopoiesis in vitro in the absence of suppressor of cytokine signalling 1 and 3
McQuilten, H. A., Izon, D. J., Chong, M. M. W., Curtis, D. J., Roberts, A. W., Kay, T. W. H., Hilton, D. J., Alexander, W. S., & Starr, R. (2008) · Molecular Immunology · doi:10.1016/j.molimm.2008.01.024 · Cited by 10 · see citing works
“Suppressor of Cytokine Signalling” Molecules in Infection and Inflammation
Carow, B., & Martin, E. (2012) · InTech eBooks · doi:10.5772/25986 · Cited by 4 · see citing works
Self-citation(2014) · Institutional Repository University of Antioquia (University of Antioquia) · doi:10.1371/journal.pone
Flagged first, then by citations
1 of the 179 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Li, L., Yu, R., Cai, T., Chen, Z., Lan, M., Zou, T., Wang, B., Wang, Q., Zhao, Y., & Cai, Y. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106939 · Cited by 381 · see citing works
Macrophage and Fibroblast Interactions in Biomaterial‐Mediated Fibrosis
Witherel, C. E., Abebayehu, D., Barker, T. H., & Spiller, K. L. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801451 · Cited by 374 · see citing works
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases
WHI-EMPC Investigators, Ligthart, S., Disease, C. E. O. C. H., Marzi, C., Aslibekyan, S. W., Mendelson, M., Conneely, K. N., Tanaka, T., Colicino, E., Waite, L. L., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1119-5 · Cited by 327 · see citing works
“The gene product of SOCS3, suppressor of cytokine signaling 3, plays a pivotal role in the innate immune system as a regulator of cytokine signaling [11].”
BackgroundT cell exhaustion during persistent viral infections
Kahan, S. M., Wherry, E. J., & Zajac, A. J. (2015) · Virology · doi:10.1016/j.virol.2014.12.033 · Cited by 321 · see citing works
Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
Sousa, C., Golebiewska, A., Poovathingal, S. K., Kaoma, T., Pires‐Afonso, Y., Martina, S., Coowar, D., Azuaje, F., Skupin, A., Balling, R., et al. (2018) · The EMBO Reports · doi:10.15252/embr.201846171 · Cited by 281 · see citing works
“Specifically, STAT3 and suppressor of cytokine signalling 3 (SOCS3) regulate inflammatory responses [54].”
Estrogen Receptor Signaling in the Immune System
Chakraborty, B., Byemerwa, J. K., Krebs, T., Lim, F., Chang, C., & McDonnell, D. P. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac017 · Cited by 275 · see citing works
Chen, H.-M., van der Touw, W., Wang, Y. S., Kang, K., Mai, S., Zhang, J., Alsina‐Beauchamp, D., Duty, J. A., Mungamuri, S. K., Zhang, B., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97570 · Cited by 254 · see citing works
“The induction of SOCS3 could result from the anti-LILRB2–mediated release of proinflammatory cytokines (IL-6 and IL-12) through activation of MAPK/NF-κB cascades (57, 58).”
Genetic and epigenetic studies of atopic dermatitis
Bin, L., & Leung, D. Y. M. (2016) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-016-0158-5 · Cited by 242 · see citing works
“Both suppressor of cytokine signaling 3 (SOCS3) and IL-10 can suppress adaptive immune responses [142, 143].”
BackgroundTargeting KRAS mutant cancers: from druggable therapy to drug resistance
Zhu, C., Guan, X., Zhang, X., Luan, X., Song, Z., Cheng, X., Zhang, W., & Qin, J.-J. (2022) · Molecular Cancer · doi:10.1186/s12943-022-01629-2 · Cited by 231 · see citing works
“HDAC5 promotes the upregulation of Chemokine ligand 2 (CCL2) by inhibiting SOCS3, thereby recruiting CCR2+ macrophages [147].”
BackgroundBone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection
Askenase, M. H., Han, S., Byrd, A. L., da Fonseca, D. M., Bouladoux, N. J., Wilhelm, C., Konkel, J. E., Hand, T. W., Lacerda‐Queiroz, N., Su, X., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.011 · Cited by 226 · see citing works
“, 2008), and Socs3, which encodes a negative regulator of inflammatory cytokine signaling (Carow and Rottenberg, 2014), was also increased.”
JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation
Gotthardt, D., Trifinopoulos, J., Sexl, V., & Putz, E. M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02590 · Cited by 214 · see citing works
“SOCS3 counteracts inflammation by inhibiting a variety of pro-inflammatory signaling pathways (202).”
BackgroundRole of interleukin-6 in cachexia
Narsale, A. A., & Carson, J. A. (2014) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000091 · Cited by 205 · see citing works
“STAT-3 phosphorylation leads to the transcription of suppressor of cytokine signaling 3 (SOCS-3) – a negative regulator of IL-6 signaling [18,19] (Fig.”
BackgroundDynamic control of type I IFN signalling by an integrated network of negative regulators
Porritt, R. A., & Hertzog, P. J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.02.002 · Cited by 197 · see citing works
Salminen, A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101573 · Cited by 197 · see citing works
“It is known that the SOCS3 protein controls many immune functions since it can induce a negative feedback response to the immune outcome mediated by several cytokines and hormones (Carow and Rottenberg, 2014).”
BackgroundProtective effect of suppressing STAT3 activity in LPS-induced acute lung injury
Zhao, J., Yu, H., Liu, Y., Gibson, S. A., Yan, Z., Xu, X., Gaggar, A., Li, P., Li, C., Wei, S., et al. (2016) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00281.2016 · Cited by 184 · see citing works
“As a JAK-STAT3 inducible protein, suppressor of cytokine signaling-3 (SOCS3) regulates STAT3 activation via a negative feedback loop in macrophages (8, 15, 31, 51).”
Peng, Y., Zhao, J., Peng, Z., Xu, W., & Yu, G. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2545-6 · Cited by 179 · see citing works
Detection of differentially abundant cell subpopulations in scRNA-seq data
Zhao, J., Jaffe, A., Li, H., Lindenbaum, O., Sefik, E., Jackson, R., Cheng, X., Flavell, R. A., & Kluger, Y. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2100293118 · Cited by 154 · see citing works
“…in moderate cases and is characterized by the expression of the inhibitory and anti-inflammatory gene IL1RN (32), as well as SOCS3 , an important regulator in restraining inflammation with previously characterized functions in regulating cytokine signaling and the subsequent response (33–35).”
BackgroundSOCS Proteins in Immunity, Inflammatory Diseases, and Immune-Related Cancer
Sobah, M. L., Liongue, C., & Ward, A. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.727987 · Cited by 171 · see citing works
Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer
Hou, P., Kapoor, A., Zhang, Q., Li, J., Wu, C.-J., Li, J., Lan, Z., Tang, M., Ma, X., Ackroyd, J. J., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0597 · Cited by 154 · see citing works
“Among the 306 top 5 candidates, we focused on Zfp36 and Socs3, because Zfp36 is known to promote AU-rich 307 mRNA decay including Ccl2 mRNA in macrophages(33), and SOCS3 is known to repress STAT 308 pathway activation (34) and negatively regulates IFNβ induced expression of Ccl2 and Cxcl10 in 309 primary astrocytes (3…”
BackgroundThe Ying and Yang of STAT3 in Human Disease
Vogel, T. P., Milner, J. D., & Cooper, M. A. (2015) · Journal of Clinical Immunology · doi:10.1007/s10875-015-0187-8 · Cited by 160 · see citing works
“DNA binding motifs and intersecting negative feedback loops it follows that an increase or decrease in the activation status of one STAT molecule can lead to alterations in others, ultimately resulting in similar functional outcomes [2, 18, 23].”
BackgroundAn Update on the Multifaceted Roles of STAT3 in the Heart
Harhous, Z., Booz, G. W., Ovize, M., Bidaux, G., & Kurdi, M. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00150 · Cited by 144 · see citing works
“As already stated, STAT3 is acutely activated downstream of IL-6 via the gp-130 receptor, and this activation is regulated by subsequent inhibition by SOCS3 (179).”
BackgroundMicroglial phenotypes in the human epileptic temporal lobe
Morin‐Brureau, M., Milior, G., Royer, J., Chali, F., Duigou, C. L., Savary, E., Blugeon, C., Jourdren, L., Akbar, D., Dupont, S., et al. (2018) · Brain · doi:10.1093/brain/awy276 · Cited by 140 · see citing works
The roles of SOCS 3 and STAT 3 in bacterial infection and inflammatory diseases
Gao, Y., Zhao, H., Wang, P., Wang, J., & Zou, L. (2018) · Scandinavian Journal of Immunology · doi:10.1111/sji.12727 · Cited by 140 · see citing works
“inflammation and induce the first level of protective immune response in different mouse models.(13) This review examines the latest advances of understanding SOCS3 and STAT3 in different cell populations during immune response.”
BackgroundNew paradigms in sepsis: from prevention to protection of failing microcirculation
Hawiger, J., Veach, R. A., & Zienkiewicz, J. (2015) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.13061 · Cited by 138 · see citing works
Monocyte differentiation and macrophage polarization
Orekhov, A. N., Orekhova, V. A., Nikiforov, N. G., Myasoedova, V. A., Grechko, A. V., Romanenko, E. B., Zhang, D., & Chistiakov, D. A. (2019) · Vessel Plus · doi:10.20517/2574-1209.2019.04 · Cited by 137 · see citing works
“Deficiency of STAT-3 in mice is characterized by impaired antimicrobial immune responses and increased release of pro-inflammatory cytokines and IL-10 in response to stimulation by LPS[73] suggesting an important role of STAT-3 in IL-10-mediated inhibition of inf lammation.”
BackgroundInfluentialNF-κB–dependent IRF1 activation programs cDC1 dendritic cells to drive antitumor immunity
Ghislat, G., Cheema, A. S., Baudoin, E., Verthuy, C., Ballester, P. J., Crozat, K., Attaf, N., Dong, C., Milpied, P. J., MALISSEN, B., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abg3570 · Cited by 129 · see citing works
Macrophage immunoregulatory pathways in tuberculosis
Rajaram, M. V. S., Ni, B., Dodd, C. E., & Schlesinger, L. S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.09.010 · Cited by 125 · see citing works
“There is some evidence for their role in TB pathogenesis [49,76,174–178] (Fig.”
BackgroundProceedings of the 35th European Peptide Symposium
Bonnet, D. (2018) · doi:10.17952/35eps · Cited by 124 · see citing works
COVID-19 Sepsis and Microcirculation Dysfunction
Colantuoni, A., D, R. M. M., Caprari, P., Ballestri, M., Capecchi, P. L., Gnasso, A., Presti, R. L., Marcoccia, A., Rossi, M., & Caimi, G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00747 · Cited by 126 · see citing works
“Activated neutrophils andmonocytes adhering to endothelial cells release reactive oxygen-derived free radicals that increase the damage to endothelium with impairment of endothelial barrier (Turer et al., 2008; Goldenberg et al., 2011; Hotchkiss et al., 2013; Carow and Rottenberg, 2014; Letsiou et al., 2015; Shalova e…”
BackgroundWoytschak, J., Keller, N., Krieg, C., Impellizzieri, D., Thompson, R. W., Wynn, T. A., Zinkernagel, A. S., & Boyman, O. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.025 · Cited by 121 · see citing works
“…both STAT3-dependent and STAT3-independent effects in neutrophils and also stimulated suppressor of cytokine signaling 3 (SOCS3), which in turn acts as an important negative feedback regulator of G-CSF receptor signaling by inhibiting STAT3 (Carow and Rottenberg, 2014; Nguyen-Jackson et al., 2010).”
BackgroundRodríguez-Giraldo, M., González-Reyes, R., Ramírez-Guerrero, S., Bonilla-Trilleras, C. E., Guardo-Maya, S., & Nava-Mesa, M. O. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113630 · Cited by 98 · see citing works
Sensory hair cell regeneration in the zebrafish lateral line
Lush, M. E., & Piotrowski, T. (2014) · Developmental Dynamics · doi:10.1002/dvdy.24167 · Cited by 112 · see citing works
Wong, C. Y. J., Al‐Salami, H., & Dass, C. R. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13359 · Cited by 112 · see citing works
“SOCS3 is a cytokine signalling suppressor that can modulate the outcome of autoimmune diseases.([61]) When JAK/STAT pathway is upregulated in hypothalamus, an increase in SOCS3 amount could inhibit IRS/PI3K/Akt insulin signalling pathway and activate inflammatory response.”
BackgroundThe Role of the IL-6 Cytokine Family in Epithelial–Mesenchymal Plasticity in Cancer Progression
Abaurrea, A., Araujo, A. M., & Caffarel, M. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158334 · Cited by 109 · see citing works
“STATs also induce the suppressors of cytokine signalling (SOCS) [37,38], which bind to tyrosine-phosphorylated JAK and tyrosine-phosphorylated gp130 [39], respectively, to stop IL-6 family signalling by means of a negative feedback loop.”
BackgroundSOCS Proteins as Regulators of Inflammatory Responses Induced by Bacterial Infections: A Review
Duncan, S. A., Baganizi, D. R., Sahu, R., Singh, S. R., & Dennis, V. A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.02431 · Cited by 103 · see citing works
“The expression of SOCS2 increased in macrophages infected with mycobacteria, and SOCS2-deficient mice exhibited a higher sensitivity to the inflammation induced by M. bovis infection (Carow and Rottenberg, 2014).”
BackgroundScarano, A., Butelli, E., Santis, S. D., Cavalcanti, E., Hill, L. M., Angelis, M. D., Giovinazzo, G., Chieppa, M., Martin, C. R., & Santino, A. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00075 · Cited by 98 · see citing works
“These changes included the downregulation of SOCS3, a positive regulator of cytokine signaling (24), Muc1, whose overexpression is associated with IBD (25) and S100a8, a component of the calprotectin complex and a clinical marker for IBD (26) (Figure S8 in Supplementary Material).”
Adams, A. T., Kennedy, N. A., Hansen, R., Ventham, N. T., O’Leary, K. R., Drummond, H. E., Noble, C. L., El-Omar, E. M., Russell, R. K., Wilson, D. C., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000179 · Cited by 93 · see citing works
IL-10/STAT3/SOCS3 Axis Is Involved in the Anti-inflammatory Effect of Benznidazole
Cevey, Á. C., Penas, F., Soto, C. D. A., Mirkin, G. A., & Goren, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01267 · Cited by 91 · see citing works
“SOCS3, one of the better studied members of the SOCS family, controls critical cellular processes such as cell growth, apoptosis, and transcription of inflammatory genes (38).”
BackgroundMeta-analysis of epigenome-wide association studies of cognitive abilities
Marioni, R. E., McRae, A. F., Bressler, J., Colicino, E., Hannon, E. J., Li, S., Prada, D., Smith, J. A., Trevisi, L., Tsai, P.-C., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-017-0008-y · Cited by 89 · see citing works
“In the fully adjusted model, significant CpGs were located in genes associated with, for example: inflammation (SOCS3, Digit Test, cg18181703) [50], epithelial cell splicing (ESRP2, Vocabulary, cg04513006) [51] and transcription activation of NOTCH proteins (MAML3, Phonemic Verbal Fluency, cg16201957) [52].”
BackgroundSOCS Proteins Participate in the Regulation of Innate Immune Response Caused by Viruses
Huang, S., Liu, K., Cheng, A., Wang, M., Cui, M., Huang, J., Zhu, D., Chen, S., Liu, M., Zhao, X., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.558341 · Cited by 87 · see citing works
“It seems that the negative regulation of other cytokine pathways is the main role of SOCS3, such as the regulation of IL-6 family cytokine signaling (55), but it has also been shown that SOCS3 can inhibit the antiviral function of IFNs.”
BackgroundA macrophage-endothelial immunoregulatory axis ameliorates septic acute kidney injury
Privratsky, J. R., Ide, S., Chen, Y., Kitai, H., Ren, J., Fradin, H., Lu, X., Souma, T., & Crowley, S. D. (2022) · Kidney International · doi:10.1016/j.kint.2022.10.008 · Cited by 87 · see citing works
Decoding the endometrial niche of Asherman’s Syndrome at single-cell resolution
Santamaría, X., Rosón, B., Pérez-Moraga, R., Venkatesan, N., Pardo‐Figuerez, M., González-Fernández, J., Llera-Oyola, J., Fernández, E., Moreno, I., Salumets, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-41656-1 · Cited by 86 · see citing works
SOCS3 and STAT3, major controllers of the outcome of infection with Mycobacterium tuberculosis
Rottenberg, M. E., & Carow, B. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.10.004 · Cited by 84 · see citing works
Self-citationThe importance of inflammation control for the treatment of chronic diabetic wounds
Worsley, A., Lui, D. H., Ntow‐Boahene, W., Song, W., Good, L., & Tsui, J. C. S. (2022) · International Wound Journal · doi:10.1111/iwj.14048 · Cited by 83 · see citing works
“Chronic hyperglycaemia has been shown to upregulate the signalling molecule suppressor of cytokine signalling 3 (SOCS3), a protein usually involved in the suppression of inflammation.(65) Surprisingly, in the diabetic chronic wound environment, this exacerbates wound inflammation.”
BackgroundSun, X., Hua, S., Chen, H.-R., Ouyang, Z., Einkauf, K. B., Tse, S. Y., Ard, K. L., Ciaranello, A. L., Yawetz, S., Sax, P. E., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.11.087 · Cited by 82 · see citing works
“Remarkably, we noted that upregulation of AXL coincided with increased expression of SOCS3, consistent with mutuallyinterdependent interactions between members of the TAM signaling network and the suppressor of cytokine signaling (SOCS) family (Carow and Rottenberg, 2014).”
BackgroundInfluentialSenger, S., Ingano, L. A. M., Freire, R. H., Anselmo, A., Zhu, W., Sadreyev, R. I., Walker, W. A., & Fasano, A. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.01.014 · Cited by 79 · see citing works
Wang, X., Yang, C., Zhao, Y., Xu, Z., Yang, W. Z., Wang, P., Lin, D., Xiong, B., Fang, J., Dong, C., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0089-4 · Cited by 78 · see citing works
Hackett, A. R., Lee, D.-H., Dawood, A., Rodriguez, M., Funk, L. H., Tsoulfas, P., & Lee, J. K. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.01.017 · Cited by 78 · see citing works
“SOCS3 has also been implicated in regulating other signaling pathways, such as IGF1/insulin, and TNFα/NFκB (Rottenberg and Carow, 2014), both of which are pathways known to be activated after SCI.”
BackgroundIdentification of a transitional fibroblast function in very early rheumatoid arthritis
Filer, A. D., Ward, L. S. C., Kemble, S., Davies, C. S., Munir, H., Rogers, R., Raza, K., Buckley, C. D., Nash, G. B., & McGettrick, H. M. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211286 · Cited by 75 · see citing works
Vigors, S., O’Doherty, J. V., Kelly, A. K., O’Shea, C. J., & Sweeney, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148145 · Cited by 74 · see citing works
“One possible explanation is that the level of SOCS3 in the LRFI group is sufficient to reduce the levels of IL-6 whereas the HRFI group despite having increased SOCS3 are unable to regulate the expression of IL-6.”
BackgroundInfluentialMarech, I., Leporini, C., Ammendola, M., Porcelli, M., Gadaleta, C. D., Russo, E., Sarro, G. D., & Ranieri, G. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.028 · Cited by 70 · see citing works
Signal transducer and activator of transcription 3
Forbes, L. R., Milner, J., & Haddad, É. (2015) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000206 · Cited by 70 · see citing works
Kahan, S. M., Bakshi, R. K., Ingram, J. T., Hendrickson, R. C., Lefkowitz, E. J., Crossman, D. K., Harrington, L. E., Weaver, C. T., & Zajac, A. J. (2022) · Science Immunology · doi:10.1126/sciimmunol.abl6322 · Cited by 67 · see citing works
Zhao, Y., Zhang, K., & Fent, K. (2016) · Environmental Science & Technology · doi:10.1021/acs.est.6b03436 · Cited by 69 · see citing works
Harling, K., Adankwah, E., Güler, A., Awuah, A. A.-A., Adu-Amoah, L., Mayatepek, E., Owusu‐Dabo, E., Nausch, N., & Jacobsen, M. (2018) · Cellular and Molecular Immunology · doi:10.1038/cmi.2018.5 · Cited by 67 · see citing works
CDK6 Inhibition: A Novel Approach in AML Management
Uras, I. Z., Sexl, V., & Kollmann, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072528 · Cited by 65 · see citing works
Luo, Y., Fang, Y., Kang, R., Lenahan, C., Gamdzyk, M., Zhang, Z., Okada, T., Tang, J., Chen, S., & Zhang, J. H. (2020) · Stroke · doi:10.1161/strokeaha.120.029951 · Cited by 65 · see citing works
Agudelo, J. S. H., Braga, T. T., Amano, M. T., Cenedeze, M. A., Cavinato, R. A., dos Santos, A. R. P., Muscará, M. N., Teixeira, S. A., Cruz, M. C., Castoldi, Â., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00881 · Cited by 64 · see citing works
“The possible explanation for this molecular interplay would be the fact that SOCS3 is a strong inhibitor of the STAT6 signaling pathway, thus interfering with IL-6 expression, which seems to be regulated downstream by miR-155 (43).”
BackgroundRegulation of human interferon signaling by transposon exonization
Pasquesi, G. I. M., Allen, H. L., Ivancevic, A. M., Barbachano-Guerrero, A., Joyner, O., Guo, K., Simpson, D. M., Gapin, K., Horton, I., Nguyen, L. L., et al. (2024) · Cell · doi:10.1016/j.cell.2024.11.016 · Cited by 63 · see citing works
Immunity and inflammation: the neglected key players in congenital heart disease?
Wienecke, L. M., Cohen, S., Bauersachs, J. K., Mebazaa, A., & Chousterman, B. G. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10187-6 · Cited by 62 · see citing works
“Hypoxia-induced SOCS3 expression can be stimulated by inflammation and infection and is involved in the myocardial adaptation to chronic hypoxia in CHD [20, 21].”
BackgroundDecoding inflammation, its causes, genomic responses, and emerging countermeasures
Hawiger, J., & Zienkiewicz, J. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12812 · Cited by 62 · see citing works
Al-Khazaleh, A. K., Zhou, X., Bhuyan, D. J., Münch, G. W., Al-Dalabeeh, E. A., Jaye, K. M., & Chang, D. (2024) · Molecules · doi:10.3390/molecules29020410 · Cited by 62 · see citing works
“NF-κ inflammation [93,94].”
Gaudio, N. D., Costanzo, A. D., Liu, N. Q., Conte, L., Migliaccio, A., Vermeulen, M., Martens, J. H. A., Stunnenberg, H. G., Nebbioso, A., & Altucci, L. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1570-9 · Cited by 61 · see citing works
EVs from BALF—Mediators of Inflammation and Potential Biomarkers in Lung Diseases
Zaręba, Ł., Szymański, J., Homoncik, Z., & Czystowska, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073651 · Cited by 58 · see citing works
“EVs derived from AMs containing SOCS3 significantly restrained STAT3 activation and reduced proliferation and survival of lung adenocarcinoma cells.”
BackgroundInfluentialZheng, Y., Joyce, B. T., Hwang, S., Ma, J., Liu, L., Allen, N. B., Krefman, A. E., Wang, J., Gao, T., Nannini, D. R., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.055484 · Cited by 58 · see citing works
Walker, D. G., Whetzel, A. M., & Lue, L. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.052 · Cited by 56 · see citing works
“…(IL) and interferons (IFN), and growth factors exert their biological effects via the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathways following interactions with cell surface receptors (Carow and Rottenberg, 2014;Dimitriou et al, 2008;Kershaw et al, 2013).”
Comprehensive analysis of an lncRNA-miRNA-mRNA competing endogenous RNA network in pulpitis
Lei, F., Zhang, H., & Xie, X. (2019) · PeerJ · doi:10.7717/peerj.7135 · Cited by 56 · see citing works
Elhennawy, M. G., Abdelaleem, E. A., Zaki, A. A., & Mohamed, W. R. (2021) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.22730 · Cited by 54 · see citing works
Targeting the STAT3 oncogenic pathway: Cancer immunotherapy and drug repurposing
Dong, Y., Chen, J., Chen, Y., & Liu, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115513 · Cited by 54 · see citing works
Macrophage polarization in response to oral commensals and pathogens
Huang, C. B., Alimova, Y. V., & Ebersole, J. L. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw011 · Cited by 51 · see citing works
“…negatively by guest on February 20, 2016 http://fem spd.oxfordjournals.org/ D ow nloaded from regulate cytokine signaling, and form part of a negative feedback loop for inflammation via STATs and NFB (Baetz, et al. 2007: 160-7, Carow and Rottenberg 2014: 58, Delgado-Ortega, et al. 2013: 1-19).”
BackgroundYan, Z., Yang, W., Parkitny, L., Gibson, S. A., Lee, K. S., Collins, F., Deshane, J. S., Cheng, W., Weinmann, A. S., Wei, H., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126520 · Cited by 52 · see citing works
“SOCS3 negatively regulates STAT3 signaling and is induced upon activation of the JAK/STAT pathway (61).”
BackgroundHu, Y., Jiang, Y., Li, S., Ma, X., Chen, M., Yang, R., Wen, S., Moynagh, P. N., Wang, B., Hu, G., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2210809119 · Cited by 51 · see citing works
Wu, R., Wang, C., Li, Z., Xiao, J., Li, C., Wang, X., Kong, P., Cao, J., Huang, F., Li, Z., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001037 · Cited by 52 · see citing works
“We found that SAHA could sensitize the melanoma cells to T-cell killing in IFN γ pretreated group (figure 4F, online supplemental figure 5D).”
Zhang, Y., Tao, G., Hu, L., Qu, J., Han, Y., Zhang, G., Qian, Y., Jiang, C., & Liu, W. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0983-6 · Cited by 50 · see citing works
“hairpin RNAs, or cell-penetrating SOCS3 proteins have been performed [43].”
Poulsen, L. L. C., Englund, A. L. M., Wissing, M. L., Andersen, C. Y., Borup, R., & Grøndahl, M. L. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.02.014 · Cited by 50 · see citing works
Weathington, N. M., O’Brien, M. E., Radder, J. E., Whisenant, T. C., Bleecker, E. R., Busse, W. W., ERZURUM, S. C., Gaston, B. M., Hastie, A. T., Jarjour, N. N., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201811-2221oc · Cited by 49 · see citing works
Zhang, S., Ji, W.-W., Wei, W., Zhan, L., & Huang, X. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04470-5 · Cited by 48 · see citing works
“Given that SOCS3 acts as a negative regulator of the JAK/STAT3 pathway [30, 31], we next assessed STAT3 activation.”
BackgroundNET Formation in Bullous Pemphigoid Patients With Relapse Is Modulated by IL-17 and IL-23 Interplay
Giusti, D., Bini, E. I., Terryn, C., Didier, K., Jan, S. L., Gatouillat, G., Durlach, A., Nesmond, S., Muller, C. B., Bernard, P., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00701 · Cited by 48 · see citing works
Epigenetics and Inflammatory Markers: A Systematic Review of the Current Evidence
González-Jaramillo, V., Portilla-Fernández, E., Glišić, M., Voortman, T., Ghanbari, M., Bramer, W. M., Chowdhury, R., Nijsten, T. E. C., Dehghan, A., Franco, O. H., et al. (2019) · International Journal of Inflammation · doi:10.1155/2019/6273680 · Cited by 48 · see citing works
“The gene SOCS3, suppressor of cytokine signalling 3, plays a pivotal role in the innate immune system as a regulator of cytokine signalling along the JAK/STAT pathway and was previously reported to have an important role in the processes of atherosclerosis [42].”
BackgroundAdaptive responses of histone modifications to resistance exercise in human skeletal muscle
Lim, C., Shimizu, J., Kawano, F., Kim, H. J., & Kim, C. K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231321 · Cited by 48 · see citing works
“Socs3 is reportedly induced by IL-6, but inhibits the IL-6-mediated JAK-STAT pathway, and suppresses inflammation [28].”
BackgroundIL-10 and socs3 Are Predictive Biomarkers of Dengue Hemorrhagic Fever
Flores-Mendoza, L. K., Estrada-Jiménez, T., Sedeño-Monge, V., Moreno, M., Manjarrez, M. D. C., González-Ochoa, G., Peña, L. M.-P., & Reyes‐Leyva, J. (2017) · Mediators of Inflammation · doi:10.1155/2017/5197592 · Cited by 47 · see citing works
“Of the eight family members, socs1 and socs3 are the most potent inhibitors of cytokine signaling mediated by the JAK/STAT pathway [18, 19].”
BackgroundFaletti, L. E., Ehl, S. R., & Heeg, M. (2021) · Biomedical Journal · doi:10.1016/j.bj.2021.03.003 · Cited by 47 · see citing works
“Additionally, SOCS3 mediates the ubiquitination and subsequent proteasome degradation of other receptors, like the G-CSF and insulin receptor [36].”
BackgroundCDK6 coordinates JAK2V617F mutant MPN via NF-κB and apoptotic networks
Uras, I. Z., Maurer, B., Nivarthi, H., Jodl, P., Kollmann, K., Prchal‐Murphy, M., Feenstra, J. D. M., Zojer, M., Lagger, S., Grausenburger, R., et al. (2019) · Blood · doi:10.1182/blood-2018-08-872648 · Cited by 46 · see citing works
Targeting STAT3: A crucial modulator of sepsis
Lei, W., Liu, D., Sun, M., Lu, C., Yang, W., Wang, C., Cheng, Y., Zhang, M., Shen, M., Yang, Z. P., et al. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30394 · Cited by 46 · see citing works
Alcaraz‐Quiles, J., Titos, E., Casulleras, M., Pavesi, M., López‐Vicario, C., Rius, B., Lopategi, A., Gottardi, A. D., Graziadei, I. W., Grønbæk, H., et al. (2016) · Hepatology · doi:10.1002/hep.28896 · Cited by 45 · see citing works
“We also assessed an SNP (rs1800871) in the gene coding for the antiinflammatory cytokine IL-10((10)) and an SNP (rs4969170) in the suppressor of cytokine signaling (SOCS) 3.((11)) The screening also included an SNP (rs3135500) coding for nucleotide-binding oligomerization domain-containing protein 2 (NOD2), a receptor…”
MethodMimetics of suppressor of cytokine signaling 3: Novel potential therapeutics in triple breast cancer
Manna, S. L., Lee, E.-M., Ouzounova, M., Natale, C. D., Novellino, E., Merlino, A., Körkaya, H., & Marasco, D. (2018) · International Journal of Cancer · doi:10.1002/ijc.31594 · Cited by 45 · see citing works
“The SOCS family proteins play crucial roles in these processes.(1) SOCSs are traditionally considered as negative feedback inhibitors of Janus Kinases-Signal Transducer and Activator of Transcription (JAK-STAT) pathway, but more recently, they have been shown to be regulated by different transcriptional, translational…”
BackgroundTargeting BRD9 for Cancer Treatment: A New Strategy
Zhu, X., Liao, Y., & Tang, L. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s286867 · Cited by 44 · see citing works
Feng, Y. M., Guo, S., Zhao, Y., Dong, H., Qian, J., Hu, Y., Wu, L., Jia, Y., & Zhao, R. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01130-3 · Cited by 44 · see citing works
“SOCS3 serves as a “brake” in the auto-regulatory feedback loop to prohibit nuclear translocation of STAT3 [31].”
BackgroundMiki, H., Pei, H., Gracias, D. T., Linden, J. M., & Croft, M. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.10.005 · Cited by 44 · see citing works
Kopalli, S. R., Prakash, A. V., & Koppula, S. (2022) · Molecules · doi:10.3390/molecules27144660 · Cited by 43 · see citing works
“The SOCS3 gene, cloned in 1997, is one of the major SOCS family proteins that have been shown to possess immunoregulatory roles in inflammatory-associated infections including AD [67,68].”
BackgroundHarwardt, T., Lukas, S., Zenger, M., Reitberger, T., Danzer, D., Übner, T., Munday, D. C., Nevels, M., & Paulus, C. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005748 · Cited by 44 · see citing works
“One of the pSTAT3 target genes encodes the suppressor of cytokine signaling 3 (SOCS3) which forms part of a negative feedback circuit by inhibiting IL6 signaling [8, 9].”
BackgroundBioengineered three-dimensional diseased intervertebral disc model revealed inflammatory crosstalk
Srivastava, A., Isa, I. L. M., Rooney, P., & Pandit, A. S. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.045 · Cited by 43 · see citing works
Sahini, N., & Borlak, J. (2016) · Translational Research: The Journal of Laboratory and Clinical Medicine · doi:10.1016/j.trsl.2016.06.003 · Cited by 47 · see citing works
Bayık, D., Tross, D., & Klinman, D. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00608 · Cited by 42 · see citing works
“org March 2018 | Volume 9 | Article 608 (SOCS3, Figure 6C) (40).”
A network of core and subtype-specific gene expression programs in myositis
Amici, D. R., Pinal‐Fernandez, I., Christopher‐Stine, L., Mammen, A. L., & Mendillo, M. L. (2021) · Acta Neuropathologica · doi:10.1007/s00401-021-02365-5 · Cited by 39 · see citing works
“This approach successfully identified hubs with overarching control of their correlated process, such as the master regulators MYOG (myogenesis [4]) and SOCS3 (NFKB [8]) (Fig.”
BackgroundSpeth, J. M., Bourdonnay, E., Penke, L. R. K., Mancuso, P., Moore, B. B., Weinberg, J. B., & Peters-Golden, M. L. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1502153 · Cited by 41 · see citing works
“As recent studies have implicated intracellular SOCS3 in the regulation of inflammation and infection (23, 24), we sought to investigate the effects of both viral and bacterial infection on extracellular SOCS3 secretion in the lung.”
BackgroundKels, M. J. T., Ng, E., Rumaih, Z. A., Pandey, P., Ruuls, S. R., Körner, H., Newsome, T. P., Chaudhri, G., & Karupiah, G. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2004615117 · Cited by 40 · see citing works
Zhang, L., Zhang, L., Pan, Y., Gao, J., Xu, Y., Li, X., Tian, Z., Chen, H., & Wang, Y. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100683 · Cited by 40 · see citing works
“(SOCS3), a critical regulator of infection and inflammation (33).”
BackgroundLin, X., Yu, S., Ren, P., Sun, X., & Jin, M. (2019) · Cellular Microbiology · doi:10.1111/cmi.13150 · Cited by 40 · see citing works
“This led us to focus on SOCS1 and SOCS3, which were reported to be involved in the antiviral response (Alexander, 2002; Carow & Rottenberg, 2014; Pothlichet, Chignard, & Si-Tahar, 2008) .”
Background
- Authors
- Carow, B., & Rottenberg, M. E.
- Affiliations
- Karolinska Institutet (SE)
- Corresponding author
- Carow, Berit
- ORCID
- Carow, Berit
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2014
- Volume
- 5
- Pages
- 58-58
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC3928676
- OpenAlex
- W2140013858
- Cited by
- 555
- References
- 179
- Citations by year
- 2026: 31 · 2025: 55 · 2024: 65 · 2023: 71 · 2022: 64 · 2021: 58 · 2020: 43 · 2019: 52 · 2018: 31 · 2017: 25 · 2016: 27 · 2015: 24 · 2014: 9
- FWCI
- 3.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Keywords
- SOCS3, suppressor of cytokine signaling, infection, inflammation, autoimmune disease, STAT3 activation, JAK kinases, cytokine signaling, receptor ubiquitination, proteasomal degradation, immune homeostasis, myeloid cells, lymphoid cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
