The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Oligonucleotides as Research, Diagnostic, and Therapeutic Agents
Open accessAbstract
Rapid drug discovery is a pressing need in the pharmaceutical industry. As new target proteins are proposed for therapeutic intervention, the methods of random screening or rational drug design may not be adequate to the challenge. SELEX1(1) -derived oligonucleotides, possessing shapes that interact with target molecules, may provide a surprising alternative to other ligand discovery technologies. In addition, the technology leads to a novel research idea that may enrich our understanding of the mechanisms by which cells and organisms integrate their metabolic activities.
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Cites
Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
Brooks, P. C., Montgomery, A. M. P., Rosenfeld, M., Reisfeld, R. A., Hu, T., Klier, G., & Cheresh, D. A. (1994) · Cell · doi:10.1016/0092-8674(94)90007-8 · Cited by 2,262
Regulating the fate of mRNA: the control of cellular iron metabolism
Klausner, R. D., Rouault, T. A., & Harford, J. B. (1993) · Cell · doi:10.1016/0092-8674(93)90046-s · Cited by 1,210
Isolation of New Ribozymes from a Large Pool of Random Sequences
Bartel, D. P., & Szostak, J. W. (1993) · Science · doi:10.1126/science.7690155 · Cited by 900
Cited by
Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery
Gold, L., Ayers, D., Bertino, J., Bock, C., Bock, A., Brody, E. N., Carter, J., Dalby, A. B., Eaton, B. E., Fitzwater, T., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015004 · Cited by 1,754
“There were many examples of high affinity RNA and DNA aptamers selected against human proteins [19].”
BackgroundSelf-citationIn Vitro Selection of Functional Nucleic Acids
Wilson, D. S., & Szostak, J. W. (1999) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.68.1.611 · Cited by 1,206
Rohloff, J. C., Gelinas, A. D., Jarvis, T. C., Ochsner, U. A., Schneider, D. J., Gold, L., & Janjic, N. (2014) · Molecular Therapy - Nucleic Acids · doi:10.1038/mtna.2014.49 · Cited by 533
Self-citationA review of molecular recognition technologies for detection of biological threat agents
Iqbal, S. S., Mayo, M. W., Bruno, J. G., Bronk, B. V., Batt, C. A., & Chambers, J. P. (2000) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(00)00108-1 · Cited by 507
Aptamers as therapeutic and diagnostic agents
Brody, E. N., & Gold, L. (2000) · Reviews in Molecular Biotechnology · doi:10.1016/s1389-0352(99)00004-5 · Cited by 494
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Metadata
- Authors
- Gold, L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 270
- Issue
- 23
- Pages
- 13581-13584
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2043266732
- Cited by
- 266
- References
- 3
- FWCI
- 9.59
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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