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Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons
Open accessAbstract
Mice that are homozygous for the targeted disruption of the gene encoding the B2 bradykinin receptor have been generated. The gene disruption results in a deletion of the entire coding sequence for the B2 receptor. The disruption of the B2 receptor gene has been confirmed by genetic, biochemical, and pharmacological analyses. Mice that are homozygous for the disruption of the B2 receptor gene are fertile and indistinguishable from their littermates by visual inspection. Bradykinin fails to produce responses in pharmacological preparations from ileum, uterus, and the superior cervical ganglia from these mice. Therefore, expression of a single gene appears to be responsible for conferring responsiveness to bradykinin in these tissues.
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Citations
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Han, E. D., MacFarlane, R. C., Mulligan, A. N., Scafidi, J., & Davis, A. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14211 · Cited by 362
Mutant G-protein-coupled receptors as a cause of human diseases
Schöneberg, T., Schulz, A., Biebermann, H., Hermsdorf, T., Römpler, H., & Sangkuhl, K. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.008 · Cited by 337
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury
Kakoki, M., McGarrah, R. W., Kim, H.-S., & Smithies, O. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701617104 · Cited by 137
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Metadata
- Authors
- Borkowski, J. A., Ransom, R. W., Seabrook, G. R., Trumbauer, M., Chen, H., Hill, R. G., Strader, C. D., & Hess, J. F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-06
- Volume
- 270
- Issue
- 23
- Pages
- 13706-13710
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2083820494
- Cited by
- 242
- References
- 0
- FWCI
- 9.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons. https://app.cochat.ai/papers/10.1074/jbc.270.23.13706
- The paper
- Borkowski, J. A., Ransom, R. W., Seabrook, G. R., Trumbauer, M., Chen, H., Hill, R. G., Strader, C. D., & Hess, J. F. (1995). Targeted Disruption of a B2 Bradykinin Receptor Gene in Mice Eliminates Bradykinin Action in Smooth Muscle and Neurons. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.23.13706
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
