The DOI matches its OpenAlex record; 16 of the 16 references it cites were found in a registry or an index.
Increased vascular permeability in C1 inhibitor–deficient mice mediated by the bradykinin type 2 receptor
Open accessAbstract
Heterozygosity for C1 inhibitor (C1INH) deficiency results in hereditary angioedema. Disruption of the C1INH gene by gene trapping enabled the generation of homozygous- and heterozygous-deficient mice. Mating of heterozygous-deficient mice resulted in the expected 1:2:1 ratio of wild-type, heterozygous, and homozygous-deficient offspring. C1INH-deficient mice showed no obvious phenotypic abnormality. However, following injection with Evans blue dye, both homozygous and heterozygous C1INH-deficient mice revealed increased vascular permeability in comparison with wild-type littermates. This increased vascular permeability was reversed by treatment with intravenous human C1INH, with a Kunitz domain plasma kallikrein inhibitor (DX88), and with a bradykinin type 2 receptor (Bk2R) antagonist (Hoe140). In addition, treatment of the C1INH-deficient mice with an angiotensin-converting enzyme inhibitor (captopril) increased the vascular permeability. Mice with deficiency of both C1INH and Bk2R demonstrated diminished vascular permeability in comparison with C1INH-deficient, Bk2R-sufficient mice. These data support the hypothesis that angioedema is mediated by bradykinin via Bk2R.
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Cites
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The Kallikrein-Kinin System: Current and Future Pharmacological Targets
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C1 inhibitor deficiency: consensus document
Gompels, M. M., Lock, R. J., Abinun, M., Bethune, C. A., Davies, G., Grattan, C., Fay, A. C., Longhurst, H. J., Morrison, L., Price, A., et al. (2005) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2005.02726.x · Cited by 411
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Bradykinin and the pathophysiology of angioedema
Cugno, M., Nussberger, J., Cicardi, M., & Agostoni, A. (2003) · International Immunopharmacology · doi:10.1016/s1567-5769(02)00162-5 · Cited by 215
Metadata
- Authors
- Han, E. D., MacFarlane, R. C., Mulligan, A. N., Scafidi, J., & Davis, A. E.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2002-04-15
- Volume
- 109
- Issue
- 8
- Pages
- 1057-1063
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1971042333
- Cited by
- 362
- References
- 16
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Han, E. D., MacFarlane, R. C., Mulligan, A. N., Scafidi, J., & Davis, A. E. (2002). Increased vascular permeability in C1 inhibitor–deficient mice mediated by the bradykinin type 2 receptor. Journal of Clinical Investigation. https://doi.org/10.1172/jci14211
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