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NF-κB Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity
Open accessAbstract
An important function of interleukin-1 (IL-1) is activation of the transcription factor NF-kappa B, which is signaled via the type I IL-1 receptor (IL-1RI). By receptor mutagenesis studies, we have identified a region of the cytoplasmic domain of IL-1RI that is required for both IL-1-mediated NF-kappa B activation and IL-1-dependent activation of a receptor-associated protein kinase activity we term IRAK. No IL-1RI mutants were found that can activate NF-kappa B in the absence of IRAK activity. Therefore, we propose that IRAK activation is a necessary step in the activation of NF-kappa B by IL-1.
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The interleukin‐1 family: 10 years of discovery 1
Dinarello, C. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.15.8001745 · Cited by 783
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MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex
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Metadata
- Authors
- Croston, G. E., Cao, Z., & Goeddel, D. V.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-07
- Volume
- 270
- Issue
- 28
- Pages
- 16514-16517
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2036475326
- Cited by
- 180
- References
- 1
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: NF-κB Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity. https://app.cochat.ai/papers/10.1074/jbc.270.28.16514
- The paper
- Croston, G. E., Cao, Z., & Goeddel, D. V. (1995). NF-κB Activation by Interleukin-1 (IL-1) Requires an IL-1 Receptor-associated Protein Kinase Activity. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.28.16514
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
