The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism
Open accessAbstract
Although the one-dimensional sequence of DNA determines the genetic constitution of an organism, topological relationships within the double helix modulate virtually every physiological function of the genome(1, 2). In the cell, the topology of DNA is orchestrated by enzymes known as topoisomerases(1, 2, 3, 4, 5, 6, 7). These ubiquitous enzymes are required for replication, transcription, and recombination and play critical roles in chromosome structure, condensation/decondensation, and segregation(1, 2, 3, 4, 5, 6, 7, 8, 9).
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Citations
Cites
Topoisomerase II Binds to Ellipticine in the Absence or Presence of DNA.
Froelich-Ammon, S. J., Patchan, M. W., Osheroff, N., & Thompson, R. B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.25.14998 · Cited by 137
Self-citationThe Strange Case of Dr. Jekyll and Mr. Hyde
OISHI, Y. (2001) · Studies in Regional Science · doi:10.2457/srs.32.139 · Cited by 134
Cited by
Cell-cycle checkpoints and cancer
Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836
Reddy, R. K., Mao, C., Baumeister, P., Austin, R. C., Kaufman, R. J., & Lee, A. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212328200 · Cited by 695
Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme
Burden, D. A., & Osheroff, N. (1998) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(98)00132-8 · Cited by 503
Self-citationSingle-strand interruptions in replicating chromosomes cause double-strand breaks
Kuzminov, A. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131009198 · Cited by 406
Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
Fortune, J. M., & Osheroff, N. (2000) · Progress in Nucleic Acid Research and Molecular Biology · doi:10.1016/s0079-6603(00)64006-0 · Cited by 366
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Metadata
- Authors
- Froelich-Ammon, S. J., & Osheroff, N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-09
- Volume
- 270
- Issue
- 37
- Pages
- 21429-21432
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1972227366
- Cited by
- 505
- References
- 2
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Froelich-Ammon, S. J., & Osheroff, N. (1995). Topoisomerase Poisons: Harnessing the Dark Side of Enzyme Mechanism. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.37.21429
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
