Cited by 270Receptor Mechanisms and SignalingNeuroendocrine regulation and behaviorNeuropeptides and Animal Physiology

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The Binding Site of Neuropeptide Vasopressin V1a Receptor

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Mouillac, Bernard, Chini, Bice, Balestre, Marie-Noëlle, Elands, Jack, Trumpp-Kallmeyer, Susanne, Hoflack, Jan, Hibert, Marcel, Jard, Serge, Barberis, Claude·1995·Journal of Biological Chemistry

DOI 10.1074/jbc.270.43.25771

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Abstract

To identify receptor functional domains underlying binding of the neurohypophysial hormones vasopressin (AVP) and oxytocin (OT), we have constructed a three-dimensional (3D) model of the V1a vasopressin receptor subtype and docked the endogenous ligand AVP. To verify and to refine the 3D model, residues likely to be involved in agonist binding were selected for site-directed mutagenesis. Our experimental results suggest that AVP, which is characterized by a cyclic structure, could be completely buried into a 15-20-A deep cleft defined by the transmembrane helices of the receptor and interact with amino acids located within this region. Moreover, the AVP-binding site is situated in a position equivalent to that described for the cationic neurotransmitters. Since all mutated residues are highly conserved in AVP and OT receptors, we propose that the same agonist-binding site is shared by all members of this receptor family. In contrast, the affinity for the antagonists tested, including those with a structure closely related to AVP, is not affected by mutations. This indicates a different binding mode for agonists and antagonists in the vasopressin receptor.

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LIGAND: A versatile computerized approach for characterization of ligand-binding systems
Munson, P. J., & Rodbard, D. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90515-1 · Cited by 8,373
Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
Henderson, R. A., Baldwin, J. M., Ceska, T. A., Zemlin, F., Beckmann, E., & Downing, K. H. (1990) · Journal of Molecular Biology · doi:10.1016/s0022-2836(05)80271-2 · Cited by 2,982
Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands
Berridge, M. J., Downes, C. P., & Hanley, M. R. (1982) · Biochemical Journal · doi:10.1042/bj2060587 · Cited by 2,130
STRUCTURE AND FUNCTION OF G PROTEIN-COUPLED RECEPTORS
Strader, C. D., Fong, T. M., Tota, M. R., Underwood, D. J., & Dixon, R. A. F. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.000533 · Cited by 1,080
The probable arrangement of the helices in G protein‐coupled receptors.
Baldwin, J. M. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05814.x · Cited by 968
Molecular cloning and expression of a receptor for human tumor necrosis factor
Schall, T. J., Lewis, M., Koller, K. J., Lee, A. L., Rice, G. C., Wong, G. H., Gatanaga, T., Granger, G. A., Lentz, R., Raab, H. E., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90816-w · Cited by 958
Projection structure of rhodopsin
Schertler, G. F. X., Villa, C., & Henderson, R. A. (1993) · Nature · doi:10.1038/362770a0 · Cited by 766
Structure and expression of a human oxytocin receptor
Kimura, T., Tanizawa, O., Mori, K., Brownstein, M., & Okayama, H. (1992) · Nature · doi:10.1038/356526a0 · Cited by 631
Molecular cloning of the receptor for human antidiuretic hormone
Birnbaumer, M., Seibold, A. M., Gilbert, S., Ishido, M., Barberis, C., Antaramián, A., Brabet, P., & Rosenthal, W. (1992) · Nature · doi:10.1038/357333a0 · Cited by 539
Self-citation
Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.
Strader, C. D., Sigal, I. S., Candelore, M. R., Rands, E., Hill, W. S., & Dixon, R. A. F. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81509-0 · Cited by 534

Show all 41 references

Research works printed but not linked: 2

Hibert, 1991, Mol. Pharmacol., 40, 8
Fraser, 1989, Mol. Pharmacol., 36, 840

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Terrillon, S., Cheng, L., Stoev, S. B., Mouillac, B., Barberis, C., Manning, M., & Durroux, T. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm010526+ · Cited by 48
Self-citation
Structural modifications of glycopeptide antibiotics
Malabarba, A., Nicas, T. I., & Thompson, R. C. (1997) · Medicinal Research Reviews · doi:10.1002/(sici)1098-1128(199701)17:1 · Cited by 140
Vasopressin receptors. A historical survey.
Jard, S. (1998) · PubMed · Cited by 48
Self-citation
Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptor
Kiss, R., Noszál, B., Rácz, Á., Falus, A., Erös, D., & Keserű, G. M. (2007) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2007.07.014 · Cited by 47
Structural Elements in the Gαs and Gαq C Termini That Mediate Selective G Protein-coupled Receptor (GPCR) Signaling
Semack, A., Sandhu, M., Malik, R. U., Vaidehi, N., & Sivaramakrishnan, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.735720 · Cited by 46
Mutational analysis and molecular modeling of the nonapeptide hormone binding domains of the [Arg8]vasotocin receptor.
Hausmann, H., Richters, A., Kreienkamp, H., Meyerhof, W., Mattes, H., Lederis, K. P., Zwiers, H., & Richter, D. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.14.6907 · Cited by 47
Antagonist and agonist binding models of the human gonadotropin-releasing hormone receptor
Söderhäll, J. A., Polymeropoulos, E. E., Paulini, K., Günther, E. G., & Kühne, R. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.05.142 · Cited by 46
Charged Extracellular Residues, Conserved throughout a G-protein-coupled Receptor Family, Are Required for Ligand Binding, Receptor Activation, and Cell-surface Expression
Hawtin, S. R., Simms, J., Conner, M. T., Lawson, Z., Parslow, R. A., Trim, J. E., Sheppard, A., & Wheatley, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607639200 · Cited by 45
Gene and cDNA cloning and characterization of the mouse V3/V1b pituitary vasopressin receptor
Ventura, M., René, P., de Keyzer, Y., BERTAGNA, X. Y., & Clauser, É. (1999) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0220251 · Cited by 45
Novel evolutionary lineages of the invertebrate oxytocin/vasopressin superfamily peptides and their receptors in the common octopus (Octopus vulgaris)
Kanda, A., Satake, H., Kawada, T., & Minakata, H. (2005) · Biochemical Journal · doi:10.1042/bj20041230 · Cited by 44
Mapping the Binding Site of Arginine Vasopressin to V 1a and V 1b Vasopressin Receptors
Rodrigo, J., Peña, A., Murat, B., Trueba, M., Durroux, T., Guillon, G., & Rognan, D. (2006) · Molecular Endocrinology · doi:10.1210/me.2006-0202 · Cited by 43
Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor
Wesley, V. J., Hawtin, S. R., Howard, H. C., & Wheatley, M. (2002) · Biochemistry · doi:10.1021/bi015990v · Cited by 41
Structural basis for the activation and ligand recognition of the human oxytocin receptor
Waltenspühl, Y., Ehrenmann, J., Vacca, S., Thom, C., Medalia, O., & Plückthun, A. (2022) · Nature Communications · doi:10.1038/s41467-022-31325-0 · Cited by 42
Chapter 2 V2R Mutations and Nephrogenic Diabetes Insipidus
Bichet, D. G. (2009) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(09)89002-9 · Cited by 42
Molecular evolution of neuropeptide receptors with regard to maintaining high affinity to their authentic ligands
Cho, H.-J., Acharjee, S., Moon, M. J., Oh, D. Y., Vaudry, H., Kwon, H. B., & Seong, J. Y. (2006) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2006.12.013 · Cited by 42
Cryo–electron microscopy structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex
Bous, J., Orcel, H., Floquet, N., Leyrat, C., Lai‐Kee‐Him, J., Gaibelet, G., Ancelin, A., Saint‐Paul, J., Trapani, S., Louet, M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg5628 · Cited by 45
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Focused library design in GPCR projects on the example of 5‐HT2c agonists: Comparison of structure‐based virtual screening with ligand‐based search methods
Bissantz, C., Schalon, C., Guba, W., & Ståhl, M. (2005) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.20651 · Cited by 42
Oxytocin Receptor Signaling in Vascular Function and Stroke
McKay, E. C., & Counts, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.574499 · Cited by 45
Identification of Amino Acid Residues That Direct Differential Ligand Selectivity of Mammalian and Nonmammalian V1a Type Receptors for Arginine Vasopressin and Vasotocin
Acharjee, S., do Rego, J. L., Oh, D. Y., Ahn, R. S., Choe, H., Vaudry, H., Kim, K., Seong, J. Y., & Kwon, H. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408909200 · Cited by 40
Molecular modeling of the human vasopressin V2 receptor/agonist complex
Czaplewski, C. R., Kaźmierkiewicz, R., & Ciarkowski, J. (1998) · Journal of Computer-Aided Molecular Design · doi:10.1023/a:1007969526447 · Cited by 39
Docking of Linear Peptide Antagonists into the Human V1a Vasopressin Receptor
Phalipou, S., Seyer, R., de la Cotte, N., Breton, C., Barberis, C., Hibert, M., & Mouillac, B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.33.23316 · Cited by 39
Self-citation
Hereditary Polyuric Disorders: New Concepts and Differential Diagnosis
Bichet, D. G. (2006) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2006.02.004 · Cited by 37
Molecular basis of ligand binding and receptor activation in the oxytocin and vasopressin receptor family
Chini, B., & Fanelli, F. (2000) · Experimental Physiology · doi:10.1111/j.1469-445x.2000.tb00008.x · Cited by 36
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Kanda, A., Takuwa‐Kuroda, K., Ukena, K., Furukawa, Y., Matsushima, O., & Minakata, H. (2003) · Journal of Endocrinology · doi:10.1677/joe.0.1790281 · Cited by 36
A molecular model of agonist and nonpeptide antagonist binding to the human V1 vascular vasopressin receptor
Thibonnier, M., Coles, P., Conarty, D. M., Plesnicher, C. L., & Shoham, M. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39056-1 · Cited by 35

Authors: Mouillac, B., Chini, B., Balestre, M.-N., Elands, J., Trumpp-Kallmeyer, S., Hoflack, J., Hibert, M., Jard, S., & Barberis, C.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Barberis, Claude
ORCID: Mouillac, Bernard
Chini, Bice
Elands, Jack
Hibert, Marcel
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1995-10
Volume: 270
Issue: 43
Pages: 25771-25777
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.270.43.25771
OpenAlex: W2062176518
Cited by: 262
References: 41
Citations by year: 2026: 2 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 8
FWCI: 5.71
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 9169 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: Institut National de la Santé et de la Recherche Médicale
Centre National de la Recherche Scientifique
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: vasopressin V1a receptor, vasopressin, oxytocin, receptor binding sites, agonist binding, antagonist binding, protein-ligand docking, site-directed mutagenesis, transmembrane helices, cyclic peptide ligands, neurohypophyseal hormones
MeSH terms: Amino Acid Sequence, Animals, Arginine Vasopressin, Binding Sites, Computer Simulation, DNA Mutational Analysis, Models, Molecular, Molecular Sequence Data, Type C Phospholipases, Protein Binding, Protein Conformation, Radioligand Assay, Recombinant Proteins, Structure-Activity Relationship, Signal Transduction, Mutagenesis, Site-Directed, Sequence Homology, Amino Acid, Receptors, Vasopressin, Receptors, Oxytocin, Rats

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The Binding Site of Neuropeptide Vasopressin V1a Receptor

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