The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Expression Cloning and Pharmacological Characterization of a Human Hippocampal Neuropeptide Y/Peptide YY Y2 Receptor Subtype
Open accessAbstract
The pancreatic polypeptide family includes neuropeptide Y (NPY), one of the most abundant neuropeptides in the mammalian nervous system, as well as peptide YY (PYY) and pancreatic polypeptide (PP). This peptide family is involved in numerous physiological processes such as memory, pain, blood pressure, appetite, anxiety, and circadian rhythm. Of the multiple Y-type receptors proposed for PP family members, only the Y1 subtype was cloned previously. We now report the isolation of a human Y2 (hhY2) receptor cDNA by expression cloning from a human hippocampal cDNA library, using a 125I-PYY binding assay. hhY2 cDNA encodes a predicted protein of 381 amino acids with low amino acid identity to the human Y1 receptor (31% overall; 41% transmembrane). 125I-PYY binding to transiently expressed hY2 receptors was saturable (pKd = 10.17) and displaceable by human PP family members in rank order: PYY (pKi = 9.47) approximately NPY (pKi = 9.27) >> PP (pKi < 6) and by peptide analogs: NPY2-36 (pKi = 8.80) approximately NPY13-36 (pKi = 8.55) approximately C2-NPY (pKi = 8.54) > NPY26-36 (pKi = 6.51) approximately [Leu31,Pro34]NPY (pKi = 6.23). Human PYY decreased [cAMP] and increased intracellular [Ca2+] in hY2-transfected 293 cells.
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Cited by
A receptor subtype involved in neuropeptide-Y-induced food intake
Gerald, C., Walker, M. W., Criscione, L., Gustafson, E. L., Batzl-Hartmann, C., Smith, K. E., Vaysse, P., Durkin, M. M., Laz, T. M., Linemeyer, D. L., et al. (1996) · Nature · doi:10.1038/382168a0 · Cited by 891
Self-citationThe hypothalamus and the control of energy homeostasis
Williams, G., Bing, C., Cai, X. J., Harrold, J. A., King, P. J., & Liu, X. H. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00612-6 · Cited by 578
Borowsky, B., Durkin, M. M., Ogozalek, K., Marzabadi, M. R., DeLeon, J., Heurich, R., Lichtblau, H., Shaposhnik, Z., Daniewska, I., Blackburn, T. P., et al. (2002) · Nature Medicine · doi:10.1038/nm741 · Cited by 506
Self-citationThe neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y
Kask, A., Harro, J., von Hörsten, S., Redrobe, J. P., Dumont, Y., & Quirion, R. (2002) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00066-5 · Cited by 358
Normal feeding behavior, body weight and leptin response require the neuropeptide Y Y2 receptor
Naveilhan, P., Hassani, H., Canals, J. M., Ekstrand, A. J., Larefalk, Å., Chhajlani, V., Arenas, E., Gedda, K., Svensson, L., Thoren, P., et al. (1999) · Nature Medicine · doi:10.1038/13514 · Cited by 270
Metadata
- Authors
- Gerald, C., Walker, M. W., Vaysse, P. J.-J., He, C., Branchek, T. A., & Weinshank, R. L.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 270
- Issue
- 45
- Pages
- 26758-26761
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2087056848
- Cited by
- 272
- References
- 35
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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