The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Autoregulation of Nisin Biosynthesis in Lactococcus lactis by Signal Transduction
Open accessAbstract
The post-translationally modified, antimicrobial peptide nisin is secreted by strains of Lactococcus lactis that contain the chromosomally located nisin biosynthetic gene cluster nisABTCIPRKFEG. When a 4-base pair deletion is introduced into the structural nisA gene (delta nisA), transcription of delta nisA is abolished. Transcription of the delta nisA gene is restored by adding subinhibitory amounts of nisin, nisin mutants, or nisin analogs to the culture medium, but not by the unmodified precursor peptide or by several other antimicrobial peptides. Upon disruption of the nisK gene, which encodes a putative sensor protein that belongs to the class of two-component regulators, transcription of delta nisA was no longer inducible by nisin. Fusion of a nisA promoter fragment to the promoterless reporter gene gusA resulted in expression of gusA in L. lactis NZ9800 (delta nisA) only upon induction with nisin species. The expression level of gusA was directly related to the amount of inducer that was added extracellularly. These results provide insight into a new mechanism of autoregulation through signal transduction in prokaryotes and demonstrate that antimicrobial peptides can exert a second function as signaling molecules.
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Cites
DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
Yanisch-Perron, C., Vieira, J., & Messing, J. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 15,041
COMMUNICATION MODULES IN BACTERIAL SIGNALING PROTEINS
Parkinson, J. S., & Kofoid, E. C. (1992) · Annual Review of Genetics · doi:10.1146/annurev.ge.26.120192.000443 · Cited by 1,450
Gasson, M. J. (1983) · Journal of Bacteriology · doi:10.1128/jb.154.1.1-9.1983 · Cited by 1,322
Casadaban, M. J., Chou, J., & Cohen, S. N. (1980) · Journal of Bacteriology · doi:10.1128/jb.143.2.971-980.1980 · Cited by 1,045
Signal transduction in bacteria
Stock, J. B., Stock, A. M., & Mottonen, J. M. (1990) · Nature · doi:10.1038/344395a0 · Cited by 670
Gross, E., & Morell, J. L. (1971) · Journal of the American Chemical Society · doi:10.1021/ja00747a073 · Cited by 605
Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings
Schnell, N., Entian, K.-D., Schneider, U., Götz, F., Zähner, H., Kellner, R., & Jung, G. (1988) · Nature · doi:10.1038/333276a0 · Cited by 538
KUIPERS, O. P., BEERTHUYZEN, M. M., SIEZEN, R. J., & DE VOS, W. M. (1993) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1993.tb18143.x · Cited by 525
Self-citationHurst, A. (1981) · Advances in Applied Microbiology · doi:10.1016/s0065-2164(08)70342-3 · Cited by 453
Cited by
Bacterial competition: surviving and thriving in the microbial jungle
Hibbing, M. E., Fuqua, C., Parsek, M. R., & Peterson, S. B. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2259 · Cited by 2,689
Preservation and Fermentation: Past, Present and Future
Paul Ross, R., Morgan, S., & Hill, C. (2002) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(02)00174-5 · Cited by 942
Controlled gene expression systems for Lactococcus lactis with the food-grade inducer nisin
de Ruyter, P. G., Kuipers, O. P., & de Vos, W. M. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.10.3662-3667.1996 · Cited by 870
Self-citationBiosynthesis and Mode of Action of Lantibiotics
Chatterjee, C., Paul, M., Xie, L., & van der Donk, W. A. (2005) · Chemical Reviews · doi:10.1021/cr030105v · Cited by 718
Lantibiotics: Peptides of Diverse Structure and Function
Willey, J. M., & van der Donk, W. A. (2007) · Annual Review of Microbiology · doi:10.1146/annurev.micro.61.080706.093501 · Cited by 621
Metadata
- Authors
- Kuipers, O. P., Beerthuyzen, M. M., de Ruyter, P. G. G. A., Luesink, E. J., & de Vos, W. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-11
- Volume
- 270
- Issue
- 45
- Pages
- 27299-27304
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2111516447
- Cited by
- 553
- References
- 34
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kuipers, O. P., Beerthuyzen, M. M., de Ruyter, P. G. G. A., Luesink, E. J., & de Vos, W. M. (1995). Autoregulation of Nisin Biosynthesis in Lactococcus lactis by Signal Transduction. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.45.27299
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
