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A Physiological Role for Saccharomyces cerevisiae Copper/Zinc Superoxide Dismutase in Copper Buffering
Open accessAbstract
The copper toxicity of yeast lacking the CUP1 metallothionein is suppressed by overexpression of the CRS4 gene. We now demonstrate that CRS4 is equivalent to SOD1, encoding copper/zinc superoxide dismutase (SOD). While overexpression of SOD1 enhanced copper resistance, a deletion of SOD1, but not SOD2 (encoding manganese SOD), conferred an increased sensitivity toward copper. This role of SOD1 in copper buffering appears unrelated to its superoxide scavenging activity, since the enzyme protected against copper toxicity in anaerobic as well as aerobic conditions. The distinct roles of SOD1 in copper and oxygen radical homeostasis could also be separated genetically: the pmr1, bsd2, and ATX1 genes that suppress oxygen toxicity in sod1 mutants failed to suppress the copper sensitivity of these cells. The Saccharomyces cerevisiae SOD1 gene is transcriptionally induced by copper and the ACE1 transactivator, and we demonstrate here that this induction of SOD1 promotes protection against copper toxicity but is not needed for the SOD1-protection against oxygen free radicals. Collectively, these findings indicate that copper/zinc SOD functions in the homeostasis of copper via mechanisms distinct from superoxide scavenging.
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Cites
Fridovich (1978) · doi:10.1126/science.210504 · Cited by 3,329
Cited by
Rae, T. D., Schmidt, P. J., Pufahl, R. A., Culotta, V. C., & V. O'Halloran, T. (1999) · Science · doi:10.1126/science.284.5415.805 · Cited by 1,629
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications
Lei, X. G., Zhu, J.-H., Cheng, W.-H., Bao, Y., Ho, Y.-S., Reddi, A. R., Holmgren, A., & Arnér, E. S. J. (2016) · Physiological Reviews · doi:10.1152/physrev.00010.2014 · Cited by 429
A Role for the Saccharomyces cerevisiae ATX1 Gene in Copper Trafficking and Iron Transport
Lin, S.-J., Pufahl, R. A., Dancis, A., O'Halloran, T. V., & Culotta, V. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.9215 · Cited by 411
Self-citationIdentification and Functional Expression of HAH1, a Novel Human Gene Involved in Copper Homeostasis
Klomp, L. W. J., Lin, S.-J., S.Yuan, D., Klausner, R. D., Culotta, V. C., & Gitlin, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.14.9221 · Cited by 379
Self-citationExtracellular and cellular mechanisms sustaining metal tolerance in ectomycorrhizal fungi
Bellion, M., Courbot, M., Jacob, C., Blaudez, D., & Chalot, M. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2005.00044.x · Cited by 311
Metadata
- Authors
- Cizewski Culotta, V., Joh, H.-D., Lin, S.-J., Hudak Slekar, K., & Strain, J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1995-12
- Volume
- 270
- Issue
- 50
- Pages
- 29991-29997
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2137771214
- Cited by
- 169
- References
- 1
- FWCI
- 9.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Cizewski Culotta, V., Joh, H.-D., Lin, S.-J., Hudak Slekar, K., & Strain, J. (1995). A Physiological Role for Saccharomyces cerevisiae Copper/Zinc Superoxide Dismutase in Copper Buffering. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.270.50.29991
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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