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Cloning and Expression of a Novel Human Brain Na+ Channel
Open accessAbstract
We have cloned a novel cDNA from human brain which encodes a non-voltage-dependent Na+ channel (BNC1). BNC1 has some sequence similarity (24-28%) with a new channel family that includes subunits of the mammalian epithelial Na+ channel, the Caenorhabditis elegans degenerins, and the Helix aspersa FMRF-amide-gated Na+ channel. Like other family members it is inhibited by amiloride. However, its predicted structure differs from other family members, its discrimination between Na+ and Li+ is different, and in contrast to other mammalian family members, coexpression with other cloned subunits of the family does not increase current. BNC1 has a unique pattern of expression with transcripts detected only in adult human brain and in spinal cord. Thus, BNC1 is the first cloned member of a new subfamily of mammalian Na+ channels. The function of BNC1 as a non-voltage-gated Na+ channel in human brain suggests it may play a novel role in neurotransmission.
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Cited by
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Metadata
- Authors
- Price, M. P., Snyder, P. M., & Welsh, M. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-04
- Volume
- 271
- Issue
- 14
- Pages
- 7879-7882
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2081317765
- Cited by
- 316
- References
- 0
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
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