The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor
Open accessAbstract
In a human neutrophil cDNA library, an orphan G-protein-coupled receptor, HNFAG09, with 37% nucleotide identity to the C5a receptor (C5a-R, CD88) was identified. A novel feature of this gene, unlike C5a-R and other G-protein-coupled receptors, is the presence of an extraordinarily large predicted extracellular loop comprised of in excess of 160 amino acid residues between transmembrane domains 4 and 5. Northern blot analysis revealed that expression of mRNA for this receptor in human tissues, while similar, was distinct from C5a-R expression. Although there were differences in expression, transcripts for both receptors were detected in tissues throughout the body and the central nervous system. Mammalian cells stably expressing HNFAG09 specifically bound 125I-C3a and responded to a C3a carboxyl-terminal analogue synthetic peptide and to human C3a but not to rC5a with a robust calcium mobilization response. HNFAG09 encodes the human anaphylatoxin C3a receptor.
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Cited by
The complement system in regulation of adaptive immunity
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The role of the anaphylatoxins in health and disease
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Complement Component 3 adapts the cerebrospinal fluid for leptomeningeal metastasis.
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Orphan G-protein-coupled receptors and natural ligand discovery
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Metadata
- Authors
- Ames, R. S., Li, Y., Sarau, H. M., Nuthulaganti, P., Foley, J. J., Ellis, C., Zeng, Z., Su, K., Jurewicz, A. J., Hertzberg, R. P., Bergsma, D. J., & Kumar, C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 271
- Issue
- 34
- Pages
- 20231-20234
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2106949710
- Cited by
- 264
- References
- 15
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ames, R. S., Li, Y., Sarau, H. M., Nuthulaganti, P., Foley, J. J., Ellis, C., Zeng, Z., Su, K., Jurewicz, A. J., Hertzberg, R. P., Bergsma, D. J., & Kumar, C. (1996). Molecular Cloning and Characterization of the Human Anaphylatoxin C3a Receptor. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.34.20231
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