The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mitogen-activated Protein Kinase-independent Pathways Mediate the Effects of Nerve Growth Factor and cAMP on Neuronal Survival
Open accessAbstract
Components of the mitogen-activated protein kinase (MAP kinase) signaling pathway, including Ras, Raf, and MAP kinase, are necessary for nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells. We have investigated the role of this pathway in promoting survival of primary sympathetic neurons that die when deprived of NGF. NGF caused rapid and sustained increases (approximately 4-fold) in the activities of the ERK-1 and ERK-2 isoforms of MAP kinase. PD 098059, an inhibitor of MAP kinase kinase activation, blocked the effects of NGF on both kinase isoforms. However, PD 098059 did not attenuate the effects of NGF on neuronal survival. In addition, MAP kinase activity was not increased by chlorophenylthio-cAMP, a cell-permeable analog of cAMP that supports neuronal survival in the absence of NGF. These findings indicate that activation of MAP kinase is not required for the actions of either cAMP or NGF on neuronal survival.
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Cites
Trophic factors and neuronal survival
Barde, Y.-A. (1989) · Neuron · doi:10.1016/0896-6273(89)90040-8 · Cited by 1,625
The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth Factor
Kaplan, D. R., Hempstead, B. L., Martin-Zanca, D., Chao, M. V., & Parada, L. F. (1991) · Science · doi:10.1126/science.1850549 · Cited by 1,379
Cited by
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944
Stanciu, M., Wang, Y., Kentor, R., Burke, N., Watkins, S., Kress, G., Reynolds, I., Klann, E., Angiolieri, M. R., Johnson, J. W., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.16.12200 · Cited by 539
Vereker, E., O'Donnell, E., & Lynch, M. A. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-18-06811.2000 · Cited by 214
Reistad, T., Mariussen, E., Ring, A., & Fonnum, F. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl198 · Cited by 125
ERK/MAPK pathway regulates GABAA receptors
Bell-Horner, C. L., Dohi, A., Nguyen, Q., Dillon, G. H., & Singh, M. (2006) · Journal of Neurobiology · doi:10.1002/neu.20327 · Cited by 52
Metadata
- Authors
- Creedon, D. J., Johnson, E. M., & Lawrence, J. C.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-08
- Volume
- 271
- Issue
- 34
- Pages
- 20713-20718
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2001418943
- Cited by
- 174
- References
- 2
- FWCI
- 7.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Mitogen-activated Protein Kinase-independent Pathways Mediate the Effects of Nerve Growth Factor and cAMP on Neuronal Survival. https://app.cochat.ai/papers/10.1074/jbc.271.34.20713
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- Creedon, D. J., Johnson, E. M., & Lawrence, J. C. (1996). Mitogen-activated Protein Kinase-independent Pathways Mediate the Effects of Nerve Growth Factor and cAMP on Neuronal Survival. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.34.20713
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
