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, a Winged Helix Transcriptional Repressor with Expression Restricted to Embryonic Stem Cells
Open accessAbstract
A novel member of the winged helix (formerly HNF-3/Forkhead) transcriptional regulatory family, termed Genesis, was isolated and characterized. Putative translation of the complete cDNA revealed the winged helix DNA binding domain to be centrally located within the protein, with regions on either side that contain known transcriptional regulatory motifs. Extensive Northern analysis of Genesis found that the message was exclusively expressed in embryonic stem cells or their malignant equivalent, embryonal carcinoma cells. The Genesis transcript was down-regulated when these cells were stimulated to differentiate. DNA sequences that Genesis protein would interact with were characterized and were found to contain a consensus similar to that found in an embryonic stem cell enhancer sequence. Co-transfection experiments revealed that Genesis is a transcriptional repressor. Genesis mapped to mouse chromosome 4 in a region syntenic with human chromosome 1p31, a site of nonrandom abnormalities in germ cell neoplasia, neuroblastoma, and acute lymphoblastic leukemia. Genesis is a candidate for regulating the phenotype of normal or malignant embryonic stem cells.
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Liu, J. K., DiPersio, C. M., & Zaret, K. S. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.2.773 · Cited by 168
Cited by
Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy
Wobus, A. M., & Boheler, K. R. (2005) · Physiological Reviews · doi:10.1152/physrev.00054.2003 · Cited by 782
Gene expression patterns in human embryonic stem cells and human pluripotent germ cell tumors
Sperger, J. M., Chen, X., Draper, J. S., Antosiewicz, J. E., Chon, C. H., Jones, S. B., Brooks, J. D., Andrews, P. W., Brown, P. O., & Thomson, J. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2235735100 · Cited by 648
Pera, M. F., Reubinoff, B., & Trounson, A. (2000) · Journal of Cell Science · doi:10.1242/jcs.113.1.5 · Cited by 554
Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation
Schubert, L. A., Jeffery, E., Zhang, Y., Ramsdell, F., & Ziegler, S. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104521200 · Cited by 548
Gajiwala, K. S., & Burley, S. K. (2000) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(99)00057-3 · Cited by 536
Metadata
- Authors
- Sutton, J., Costa, R., Klug, M., Field, L., Xu, D., Largaespada, D. A., Fletcher, C. F., Jenkins, N. A., Copeland, N. G., Klemsz, M., & Hromas, R.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-09
- Volume
- 271
- Issue
- 38
- Pages
- 23126-23133
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2122229386
- Cited by
- 166
- References
- 1
- FWCI
- 3.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sutton, J., Costa, R., Klug, M., Field, L., Xu, D., Largaespada, D. A., Fletcher, C. F., Jenkins, N. A., Copeland, N. G., Klemsz, M., & Hromas, R. (1996). , a Winged Helix Transcriptional Repressor with Expression Restricted to Embryonic Stem Cells. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.38.23126
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