The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy
Abstract
Stem cells represent natural units of embryonic development and tissue regeneration. Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity and developmental potential to differentiate into virtually any cell type of an organism. Mouse ES cells, which are established as permanent cell lines from early embryos, can be regarded as a versatile biological system that has led to major advances in cell and developmental biology. Human ES cell lines, which have recently been derived, may additionally serve as an unlimited source of cells for regenerative medicine. Before therapeutic applications can be realized, important problems must be resolved. Ethical issues surround the derivation of human ES cells from in vitro fertilized blastocysts. Current techniques for directed differentiation into somatic cell populations remain inefficient and yield heterogeneous cell populations. Transplanted ES cell progeny may not function normally in organs, might retain tumorigenic potential, and could be rejected immunologically. The number of human ES cell lines available for research may also be insufficient to adequately determine their therapeutic potential. Recent molecular and cellular advances with mouse ES cells, however, portend the successful use of these cells in therapeutics. This review therefore focuses both on mouse and human ES cells with respect to in vitro propagation and differentiation as well as their use in basic cell and developmental biology and toxicology and presents prospects for human ES cells in tissue regeneration and transplantation.
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Cites
Multilineage potential of adult human mesenchymal stem cells
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Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease
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Self-citation
Cited by
Roles of TGF-β family signaling in stem cell renewal and differentiation
Watabe, T., & Miyazono, K. (2009) · Cell Research · doi:10.1038/cr.2008.323 · Cited by 428
Li, W., Sun, W., Zhang, Y., Wei, W., Ambasudhan, R., Xia, P., Talantova, M., Lin, T., Kim, J., Wang, X., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014041108 · Cited by 375
Murry, C. E., Reinecke, H., & Pabon, L. M. (2006) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2006.02.002 · Cited by 360
Generation of functional thyroid from embryonic stem cells
Antonica, F., Kasprzyk, D. F., Opitz, R., Iacovino, M., Liao, X.-H., Dumitrescu, A. M., Refetoff, S., Peremans, K., Manto, M., Kyba, M., et al. (2012) · Nature · doi:10.1038/nature11525 · Cited by 359
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Metadata
- Authors
- Wobus, A. M., & Boheler, K. R.
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2005-04
- Volume
- 85
- Issue
- 2
- Pages
- 635-678
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- OpenAlex
- W2100012145
- Cited by
- 782
- References
- 10
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
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