Neurite outgrowth in brain neurons induced by heparin-binding growth-associated molecule (HB-GAM) depends on the specific interaction of HB-GAM with heparan sulfate at the cell surface.

A modified uronic acid carbazole reaction

Bitter, T., & Muir, H. M. (1962) · Analytical Biochemistry · doi:10.1016/0003-2697(62)90095-7 · Cited by 6,239 · see citing works

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440 · see citing works

Proteoglycans as modulators of growth factor activities

Ruoslahti, E. I., & Yamaguchi, Y. (1991) · Cell · doi:10.1016/0092-8674(91)90308-l · Cited by 1,342 · see citing works

Biology of the Syndecans: A Family of Transmembrane Heparan Sulfate Proteoglycans

Bernfield, M. R., Kokenyesi, R., Kato, M., Hinkes, M. T., Spring, J., Gallo, R. L., & Lose, E. J. (1992) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.08.110192.002053 · Cited by 1,099 · see citing works

Structures and Immunochemical Properties of Oligosaccharides Isolated from Pig Submaxillary Mucins

Carlson, D. M., & Blackwell, C. (1968) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)93649-5 · Cited by 981 · see citing works

Formation of anhydrosugars in the chemical depolymerization of heparin

Shively, J. E., & Conrad, H. E. (1976) · Biochemistry · doi:10.1021/bi00663a005 · Cited by 905 · see citing works

Activating and inhibitory heparin sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4.

Guimond, S. E., Maccarana, M., Olwin, B. B., Lindahl, U., & Rapraeger, A. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80471-2 · Cited by 545 · see citing works

cDNA cloning and sequencing of a new gene intensely expressed in early differentiation stages of embryonal carcinoma cells and in mid-gestation period of mouse embryogenesis

Kadomatsu, K., Tomomura, M., & Muramatsu, T. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80505-9 · Cited by 488 · see citing works

Cell surface heparan sulfate proteoglycans.

Yanagishita, M., & Hascall, V. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50108-9 · Cited by 477 · see citing works

Cloning and Expression of a Developmentally Regulated Protein That Induces Mitogenic and Neurite Outgrowth Activity

Li, Y.-S., Milner, P. G., Chauhan, A. K., Watson, M. A., Hoffman, R. M., Kodner, C. M., Milbrandt, J., & Deuel, T. F. (1990) · Science · doi:10.1126/science.2270483 · Cited by 475 · see citing works

Minimal sequence in heparin/heparan sulfate required for binding of basic fibroblast growth factor.

Maccarana, M., Casu, B., & Lindahl, U. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80470-0 · Cited by 455 · see citing works

An 18‐kd heparin‐binding protein of developing brain that is distinct from fibroblast growth factors.

Rauvala, H. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08443.x · Cited by 373 · see citing works

More to “heparin” than anticoagulation

Lindahl, U., Lidholt, K., Spillmann, D., & Kjellén, L. (1994) · Thrombosis Research · doi:10.1016/0049-3848(94)90136-8 · Cited by 340 · see citing works

Interaction of hepatocyte growth factor with heparan sulfate. Elucidation of the major heparan sulfate structural determinants

Lyon, M., Deakin, J. A., Mizuno, K., Nakamura, T., & Gallagher, J. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78113-7 · Cited by 318 · see citing works

Interactions of developing neurons with the extracellular matrix

Letourneau, P. C., Condic, M., & Snow, D. M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-03-00915.1994 · Cited by 304 · see citing works

Expression of the heparin-binding cytokines, midkine (MK) and HB-GAM (pleiotrophin) is associated with epithelial-mesenchymal interactions during fetal development and organogenesis

Mitsiadis, T. A., Salmivirta, M., Muramatsu, T., Muramatsu, H., Rauvala, H., Lehtonen, E., Jalkanen, M., & Thesleff, I. (1995) · Development · doi:10.1242/dev.121.1.37 · Cited by 292 · see citing works

Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3).

Raulo, E., Chernousov, M. A., Carey, D., Nolo, R. M., & Rauvala, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99975-8 · Cited by 284 · see citing works

Molecular cloning of the 18-kDa growth-associated protein of developing brain.

Merenmies, J. M., & Rauvala, H. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44817-4 · Cited by 257 · see citing works

Molecular distinctions between heparan sulphate and heparin. Analysis of sulphation patterns indicates that heparan sulphate and heparin are separate families of N-sulphated polysaccharides

Gallagher, J. T., & Walker, A. (1985) · Biochemical Journal · doi:10.1042/bj2300665 · Cited by 254 · see citing works

Liver heparan sulfate structure. A novel molecular design

Lyon, M., Deakin, J. A., & Gallagher, J. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)78112-5 · Cited by 240 · see citing works

Molecular cloning and characterization of N-syndecan, a novel transmembrane heparan sulfate proteoglycan

Carey, D., Evans, D. M., Stahl, R., Asundi, V. K., Conner, K. J., Garbes, P., & Cizmeci-Smith, G. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.117.1.191 · Cited by 203 · see citing works

Specific heparan sulfate saccharides mediate the activity of basic fibroblast growth factor.

Walker, A., Turnbull, J. E., & Gallagher, J. T. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42201-0 · Cited by 200 · see citing works

Structural characterization of the oligosaccharides formed by depolymerization of heparin with nitrous acid.

Bienkowski, M. J., & Conrad, H. E. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89740-x · Cited by 200 · see citing works

The affinity of fibroblast growth factors (FGFs) for heparin; FGF-heparan sulfate interactions in cells and extracellular matrix

Klagsbrun, M. (1990) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(90)90084-r · Cited by 178 · see citing works

Structure and affinity for antithrombin of heparan sulfate chains derived from basement membrane proteoglycans.

Pejler, G., Bäckström, G., Lindahl, U., Paulsson, M., Dziadek, M. A., Fujiwara, S., & Timpl, R. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)61150-0 · Cited by 130 · see citing works

Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues

Tezuka, K.-I., Takeshita, S., Hakeda, Y., Kumegawa, M., Kikuno, R. F., & Hashimoto-Gotoh, T. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(05)81048-4 · Cited by 123 · see citing works

N-syndecan (syndecan 3) from neonatal rat brain binds basic fibroblast growth factor

Chernousov, M. A., & Carey, D. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85488-1 · Cited by 121 · see citing works

Secretion and biological activities of heparin-binding growth-associated molecule. Neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein.

Raulo, E., Julkunen, I., Merenmies, J. M., Pihlaskari, R., & Rauvala, H. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49925-0 · Cited by 116 · see citing works

Proteoglycans in the nervous system

Lander, A. D. (1993) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(93)90143-m · Cited by 114 · see citing works

Structure and biological activities of a heparin-derived hexasaccharide with high affinity for basic fibroblast growth factor.

Tyrrell, D. J., Ishihara, M., Rao, N. L., Horne, A. P., Kiefer, M. C., Stauber, G. B., Lam, L. H., & Stack, R. J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53450-5 · Cited by 107 · see citing works

Combined Alcian Blue and Silver Staining of Subnanogram Quantities of Proteoglycans and Glycosaminoglycans in Sodium Dodecyl Sulfate-Polyacrylamide Gels

Møller, H. J., Heinegård, D. K., & Poulsen, J. H. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1098 · Cited by 102 · see citing works

Structure of a retinoic acid-responsive gene, MK, which is transiently activated during the differentiation of embryonal carcinoma cells and the mid-gestation period of mouse embryogenesis.

Matsubara, S., Tomomura, M., Kadomatsu, K., & Muramatsu, T. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38868-4 · Cited by 99 · see citing works

The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cells

Peng, H. B., Ali, A., Dai, Z., Daggett, D., Raulo, E., & Rauvala, H. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-03027.1995 · Cited by 99 · see citing works

The adhesive and neurite-promoting molecule p30: analysis of the amino-terminal sequence and production of antipeptide antibodies that detect p30 at the surface of neuroblastoma cells and of brain neurons.

Rauvala, H., Merenmies, J. M., Pihlaskari, R., Korkolainen, M., Huhtala, M.-L., & Panula, P. (1988) · The Journal of Cell Biology · doi:10.1083/jcb.107.6.2293 · Cited by 96 · see citing works

Expression of HB-GAM (heparin-binding growth-associated molecules) in the pathways of developing axonal processes in vivo and neurite outgrowth in vitro induced by HB-GAM

Rauvala, H., Vanhala, A., Ċastrén, E., Nolo, R. M., Raulo, E., Merenmies, J. M., & Panula, P. (1994) · Developmental Brain Research · doi:10.1016/0165-3806(94)90121-x · Cited by 93 · see citing works

Structural and functional characterization of full-length heparin-binding growth associated molecule.

Hampton, B., Marshak, D. R., & Burgess, W. H. (1992) · Molecular Biology of the Cell · doi:10.1091/mbc.3.1.85 · Cited by 88 · see citing works

Cloning, Characterization and Developmental Regulation of Two Members of a Novel Human Gene Family of Neurite Outgrowth-Promoting Proteins

Kretschmer, P. J., Fairhurst, J. L., Decker, M. M., Chan, C. P., Gluzman, Y., Böhlen, P., & Kovesdi, I. (1991) · Growth Factors · doi:10.3109/08977199109000275 · Cited by 76 · see citing works

Influence of ionic strength and pH on the interaction between high-affinity heparin and antithrombin

Nordenman, B., & Björk, I. (1981) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(81)90289-0 · Cited by 58 · see citing works

Amino acid sequence and characterization of a heparin-binding neurite-promoting factor (p18) from bovine brain.

Kuo, M. D., Oda, Y., Huang, J. S., & Huang, S. S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)30574-4 · Cited by 56 · see citing works

Biosynthesis of heparan sulfate in rat liver. Characterization of polysaccharides obtained with intact cells and with a cell-free system.

Riesenfeld, J., Hözok, M., & Lindahl, U. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34536-8 · Cited by 52 · see citing works

Molecular cloning of RI-HB, a heparin binding protein regulated by retinoic acid

Urios, P., Duprez, D., Caër, J. L., Courtois, Y., Vigny, M., & Laurent, M. (1991) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(91)91610-o · Cited by 50 · see citing works

Co-expression of heparin-binding growth-associated molecule (HB-GAM) and N-syndecan (syndecan-3) in developing rat brain

Nolo, R. M., Kaksonen, M., Raulo, E., & Rauvala, H. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(94)11551-1 · Cited by 46 · see citing works

Syndecan: Regulator of Cell Morphology and Growth Factor Action at the Cell-matrix Interface.

Jalkanen, M., Elenius, K., & Rapraeger, A. C. (1993) · Trends in Glycoscience and Glycotechnology · doi:10.4052/tigg.5.107 · Cited by 26 · see citing works

Syndecans: multifunctional cell-surface co-receptors

Carey, D. J. (1997) · Biochemical Journal · doi:10.1042/bj3270001 · Cited by 687 · see citing works

Pleiotrophin signals increased tyrosine phosphorylation of β-catenin through inactivation of the intrinsic catalytic activity of the receptor-type protein tyrosine phosphatase β/ζ

Meng, K., Rodríguez‐Peña, A., Dimitrov, T., Chen, W., Yamin, M., Noda, M., & Deuel, T. F. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.020487997 · Cited by 414 · see citing works

Midkine and Pleiotrophin: Two Related Proteins Involved in Development, Survival, Inflammation and Tumorigenesis

Muramatsu, T. (2002) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003231 · Cited by 404 · see citing works

Structure and biological interactions of heparin and heparan sulfate

Casu, B., & Lindahl, U. (2001) · Advances in carbohydrate chemistry and biochemistry · doi:10.1016/s0065-2318(01)57017-1 · Cited by 372 · see citing works

Syndecans in tumor cell adhesion and signaling

Beauvais, D. M., & Rapraeger, A. C. (2004) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-2-3 · Cited by 256 · see citing works

Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth.

Kinnunen, T., Kaksonen, M., Saarinen, J., Kalkkinen, N., Peng, H. B., & Rauvala, H. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10702 · Cited by 234 · see citing works

Involvement of Receptor-like Protein Tyrosine Phosphatase ζ/RPTPβ and Its Ligand Pleiotrophin/Heparin-binding Growth-associated Molecule (HB-GAM) in Neuronal Migration

Maeda, N., & Noda, M. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.1.203 · Cited by 222 · see citing works

The syndecans, tuners of transmembrane signaling

Zimmermann, P., & David, G. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.9001.s91 · Cited by 216 · see citing works

Cell-surface heparan sulfate is involved in the repulsive guidance activities of Slit2 protein

Hu, H. (2001) · Nature Neuroscience · doi:10.1038/89482 · Cited by 201 · see citing works

Incorporation of heparin‐binding peptides into fibrin gels enhances neurite extension: an example of designer matrices in tissue engineering

Sakiyama‐Elbert, S. E., Schense, J. C., & Hubbell, J. A. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2214 · Cited by 190 · see citing works

Nervous system proteoglycans as modulators of neurite outgrowth

Bovolenta, P., & Fernaud-Espinosa, I. (2000) · Progress in Neurobiology · doi:10.1016/s0301-0082(99)00044-1 · Cited by 189 · see citing works

Behavioral and Neurochemical Alterations in Mice Deficient in Anaplastic Lymphoma Kinase Suggest Therapeutic Potential for Psychiatric Indications

Bilsland, J. G., Wheeldon, A., Mead, A., Znamenskiy, P., Almond, S., Waters, K. A., Thakur, M., Beaumont, V., Bonnert, T. P., Heavens, R., et al. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301446 · Cited by 188 · see citing works

Synaptic plasticity and cell cycle activation in neurons are alternative effector pathways: the 'Dr. Jekyll and Mr. Hyde concept' of Alzheimer's disease or the yin and yang of neuroplasticity

Arendt, T. (2003) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2003.09.007 · Cited by 188 · see citing works

Proteoglycans and neuronal migration in the cerebral cortex during development and disease

Maeda, N. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00098 · Cited by 181 · see citing works

Molecular Interactions of Neural Chondroitin Sulfate Proteoglycans in the Brain Development

Oohira, A., Matsui, F., Tokita, Y., Yamauchi, S., & Aono, S. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1999.1598 · Cited by 161 · see citing works

Solution structure of midkine, a new heparin‐binding growth factor

Iwasaki, W., Nagata, K., Hatanaka, H., Inui, T., Kimura, T., Muramatsu, T., Yoshida, K., Tasumi, M., & Inagaki, F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.6936 · Cited by 153 · see citing works

Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility

Rauvala, H., Huttunen, H. J., Fages, C., Kaksonen, M., Kinnunen, T. K., Imai, S., Raulo, E., & Kilpeläinen, I. (2000) · Matrix Biology · doi:10.1016/s0945-053x(00)00084-6 · Cited by 143 · see citing works

Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms

Kim, J., Yoon, H., Basak, J., & Kim, J. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0248 · Cited by 141 · see citing works

Distinct Bone Marrow Sources of Pleiotrophin Control Hematopoietic Stem Cell Maintenance and Regeneration

Himburg, H. A., Termini, C. M., Schlussel, L., Kan, J., Li, M., Zhao, L., Fang, T., Sasine, J. P., Chang, V. Y., & Chute, J. P. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.07.003 · Cited by 140 · see citing works

Neuronal Cell Adhesion, Mediated by the Heparin-binding Neuroregulatory Factor Midkine, Is Specifically Inhibited by Chondroitin Sulfate E

Ueoka, C., Kaneda, N., Okazaki, I., Nadanaka, S., Muramatsu, T., & Sugahara, K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002538200 · Cited by 136 · see citing works

Essential role of heparan sulfates in axon navigation and targeting in the developing visual system

Walz, A., McFarlane, S., Brickman, Y. G., Nurcombe, V., Bartlett, P. F., & Holt, C. E. (1997) · Development · doi:10.1242/dev.124.12.2421 · Cited by 134 · see citing works

α4β1- and α6β1-integrins are functional receptors for midkine, a heparin-binding growth factor

Muramatsu, H., Zou, P., Suzuki, H., Oda, Y., Chen, G., Sakaguchi, N., Sakuma, S., Maeda, N., Noda, M., Takada, Y., et al. (2004) · Journal of Cell Science · doi:10.1242/jcs.01423 · Cited by 127 · see citing works

Osteoblast Recruitment and Bone Formation Enhanced by Cell Matrix–associated Heparin-binding Growth-associated Molecule (HB-GAM)

Imai, S., Kaksonen, M., Raulo, E., Kinnunen, T. K., Fages, C., Meng, X., Lakso, M., & Rauvala, H. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.143.4.1113 · Cited by 121 · see citing works

Reg1ulatory Role and Molecular Interactions of a Cell-Surface Heparan Sulfate Proteoglycan (N-syndecan) in Hippocampal Long-Term Potentiation

Lauri, S. E., Kaukinen, S., Kinnunen, T. K., Ylinen, A., Imai, S., Kaila, K., Taira, T., & Rauvala, H. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-04-01226.1999 · Cited by 118 · see citing works

Direct Evidence for the Nonrandom Nature of Al Substitution in Zeolite ZSM-5: An Investigation by27Al MAS and MQ MAS NMR

Han, O. H., Kim, C.-S., & Hong, S. B. (2002) · Angewandte Chemie · doi:10.1002/1521-3757(20020201)114:3 · Cited by 20 · see citing works

Fell–Muir Lecture: Heparan sulphate and the art of cell regulation: a polymer chain conducts the protein orchestra

Gallagher, J. T. (2015) · International Journal of Experimental Pathology · doi:10.1111/iep.12135 · Cited by 117 · see citing works

Inhibiting Glycosaminoglycan Chain Polymerization Decreases the Inhibitory Activity of Astrocyte-Derived Chondroitin Sulfate Proteoglycans

Laabs, T. L., Wang, H., Katagiri, Y., McCann, T. E., Fawcett, J. W., & Geller, H. M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2807-07.2007 · Cited by 117 · see citing works

New Insights into the Heparan Sulfate Proteoglycan-binding Activity of Apolipoprotein E

Libeu, C. P., Lund-Katz, S., Phillips, M. C., Wehrli, S., Hernáiz, M. J., Capila, I., Linhardt, R. J., Raffaı̈, R. L., Newhouse, Y. M., Zhou, F., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104746200 · Cited by 113 · see citing works

N-syndecan deficiency impairs neural migration in brain

Hienola, A., Tumova, S., Kulesskiy, E., & Rauvala, H. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200602043 · Cited by 113 · see citing works

Heparin-binding Growth-associated Molecule Contains Two Heparin-binding β-Sheet Domains That Are Homologous to the Thrombospondin Type I Repeat

Kilpeläinen, I., Kaksonen, M., Kinnunen, T. K., Avikainen, H., Fath, M. A., Linhardt, R. J., Raulo, E., & Rauvala, H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13564 · Cited by 111 · see citing works

HB-GAM (HEPARIN-BINDING GROWTH-ASSOCIATED MOLECULE) AND HEPARIN-TYPE GLYCANS IN THE DEVELOPMENT AND PLASTICITY OF NEURON-TARGET CONTACTS

Rauvala, H. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00007-5 · Cited by 106 · see citing works

Proteoglycans in retina

Inatani, M., & Tanihara, H. (2002) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00009-5 · Cited by 105 · see citing works

Pleiotrophin and midkine, a family of mitogenic and angiogenic heparin–binding growth and differentiation factors

Zhang, N., & Deuel, T. F. (1999) · Current Opinion in Hematology · doi:10.1097/00062752-199901000-00008 · Cited by 102 · see citing works

A Novel Combination of Factors, Termed SPIE, which Promotes Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells

Vazin, T., Becker, K. G., Chen, J., Spivak, C. E., Lupica, C. R., Zhang, Y., Worden, L. T., & Freed, W. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006606 · Cited by 94 · see citing works

Heparin-binding Growth Factor, Pleiotrophin, Mediates Neuritogenic Activity of Embryonic Pig Brain-derived Chondroitin Sulfate/Dermatan Sulfate Hybrid Chains

Bao, X., Mikami, T., Yamada, S., Faissner, A., Muramatsu, T., & Sugahara, K. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413423200 · Cited by 89 · see citing works

Pleiotrophin/Osteoblast-Stimulating Factor 1: Dissecting Its Diverse Functions in Bone Formation

Tare, R. S., Oreffo, R. O. C., Clarke, N. M. P., & Roach, H. I. (2002) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2002.17.11.2009 · Cited by 85 · see citing works

Differential involvement of the extracellular 6‐O‐endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity

Kalus, I., Salmen, B., Viebahn, C., FIGURA, K. V., Schmitz, D., D’Hooge, R., & Dierks, T. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00558.x · Cited by 82 · see citing works

Isolation and characterization of heparan sulfate from various murine tissues

Warda, M., Toida, T., Zhang, F., Sun, P., Munoz, E. M., Xie, J., & Linhardt, R. J. (2006) · Glycoconjugate Journal · doi:10.1007/s10719-006-7668-1 · Cited by 81 · see citing works

Long‐Term Maintenance of Hematopoietic Stem Cells Does Not Require Contact with Embryo‐Derived Stromal Cells in Cocultures

Oostendorp, R. A. J., Robin, C., Steinhoff, C., Marz, S., Bräuer, R., Nuber, U. A., Dzierzak, E. A., & Peschel, C. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0120 · Cited by 81 · see citing works

Pleiotrophin exhibits a trophic effect on survival of dopaminergic neurons in vitro

Hida, H., Jung, C., Wu, C., Kim, H., Kodama, Y., Masuda, T., & Nishino, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02661.x · Cited by 80 · see citing works

Glycosaminoglycan structures required for strong binding to midkine, a heparin-binding growth factor

Zou, P. (2002) · Glycobiology · doi:10.1093/glycob/cwg001 · Cited by 78 · see citing works

Specific structural features of syndecans and heparan sulfate chains are needed for cell signaling

Lopes, C. C., Dietrich, C. P., & Nader, H. B. (2006) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2006000200001 · Cited by 78 · see citing works

Increased syndecan expression by pleiotrophin and FGF receptor‐expressing astrocytes in injured brain tissue

Iseki, K., Hagino, S., Mori, T., Zhang, Y., Yokoya, S., Takaki, H., Tase, C., Murakawa, M., & Wanaka, A. (2002) · Glia · doi:10.1002/glia.10078 · Cited by 78 · see citing works

Neuritogenic Activity of Chondroitin/Dermatan Sulfate Hybrid Chains of Embryonic Pig Brain and Their Mimicry from Shark Liver

Li, F., Shetty, A. K., & Sugahara, K. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609296200 · Cited by 77 · see citing works

N‐Syndecan and HB‐GAM (Heparin‐Binding Growth‐Associated Molecule) associate with early axonal tracts in the rat brain

Kinnunen, A., Kinnunen, T. K., Kaksonen, M., Nolo, R. M., Panula, P., & Rauvala, H. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00082.x · Cited by 75 · see citing works

Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease

Marchionini, D. M., Lehrmann, E., Chu, Y., He, B., Sortwell, C. E., Becker, K. G., Freed, W. J., Kordower, J. H., & Collier, T. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.028 · Cited by 69 · see citing works

HB-GAM inhibits proliferation and enhances differentiation of neural stem cells

Hienola, A., Pekkanen-Mattila, M., Raulo, E., Vanttola, P., & Rauvala, H. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.01.018 · Cited by 68 · see citing works

Flexible Roles for Proteoglycan Sulfation and Receptor Signaling

Yu, P., Pearson, C. S., & Geller, H. M. (2018) · Trends in Neurosciences · doi:10.1016/j.tins.2017.10.005 · Cited by 67 · see citing works

Schwann Cell Type V Collagen Inhibits Axonal Outgrowth and Promotes Schwann Cell Migration via Distinct Adhesive Activities of the Collagen and Noncollagen Domains

Chernousov, M. A., Stahl, R. C., & Carey, D. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06125.2001 · Cited by 57 · see citing works

HARP Induces Angiogenesis in Vivo and in Vitro: Implication of N or C Terminal Peptides

Papadimitriou, Ε., Polykratis, A., Courty, J., Koolwijk, P., Héroult, M., & Katsoris, P. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4574 · Cited by 52 · see citing works

Glycosaminoglycans Differentially Bind HARP and Modulate Its Biological Activity

Vacherot, F., Delbé, J., Héroult, M., Barritault, D., Fernig, D. G., & Courty, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7741 · Cited by 52 · see citing works

Proteoglycans: Road Signs for Neurite Outgrowth

Snow, D., & Beller, J. A. (2014) · Neural Regeneration Research · doi:10.4103/1673-5374.128235 · Cited by 47 · see citing works

The Survival-promoting Peptide Y-P30 Enhances Binding of Pleiotrophin to Syndecan-2 and -3 and Supports Its Neuritogenic Activity

Landgraf, P., Wahle, P., Pape, H., Gundelfinger, E. D., & Kreutz, M. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800963200 · Cited by 47 · see citing works

Heparan sulphate and HB‐GAM (heparin‐binding rowth‐associated molecule) in the development of the thalamocortical pathway of rat brain

Kinnunen, A., Niemi, M., Kinnunen, T. K., Kaksonen, M., Nolo, R. M., & Rauvala, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00457.x · Cited by 47 · see citing works

The Binding of Chondroitin Sulfate to Pleiotrophin/Heparin-binding Growth-associated Molecule Is Regulated by Chain Length and Oversulfated Structures

Maeda, N., Fukazawa, N., & Hata, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507750200 · Cited by 44 · see citing works

The Two Thrombospondin Type I Repeat Domains of the Heparin-binding Growth-associated Molecule Bind to Heparin/Heparan Sulfate and Regulate Neurite Extension and Plasticity in Hippocampal Neurons

Raulo, E., Tumova, S., Pavlov, I., Pekkanen-Mattila, M., Hienola, A., Klankki, E., Kalkkinen, N., Taira, T., Kilpeläinen, I., & Rauvala, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506457200 · Cited by 44 · see citing works

Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans

Rauvala, H., Николаевич, П. М., Kuja‐Panula, J., & Kulesskaya, N. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.206630 · Cited by 43 · see citing works

Midkine promotes perineural invasion in human pancreatic cancer

Yao, J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i11.3018 · Cited by 42 · see citing works

The role of pleiotrophin in bone repair

Λάμπρου, Μ., Kaspiris, A., Panagiotopoulos, E. C., Giannoudis, P. V., & Papadimitriou, Ε. (2014) · Injury · doi:10.1016/j.injury.2014.10.013 · Cited by 42 · see citing works

Midkine, a heparin‐binding growth factor, is expressed in neural precursor cells and promotes their growth

Zou, P., Muramatsu, H., Miyata, T., & Muramatsu, T. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04138.x · Cited by 40 · see citing works

Structure and Functions of Lectins in the Central and Peripheral Nervous System

Zanetta, J. (1998) · Cells Tissues Organs · doi:10.1159/000046457 · Cited by 40 · see citing works

Heparin Is a Unique Marker of Progenitors in the Glial Cell Lineage

Stringer, S. E., Mayer‐Pröschel, M., Kalyani, A. J., Rao, M. S., & Gallagher, J. T. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.36.25455 · Cited by 38 · see citing works

The Glycosaminoglycan Side Chains and Modular Core Proteins of Heparan Sulphate Proteoglycans and the Varied Ways They Provide Tissue Protection by Regulating Physiological Processes and Cellular Behaviour

Farrugia, B. L., & Melrose, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241814101 · Cited by 37 · see citing works

Expression of Pleiotrophin and its Receptors in Human Placenta Suggests Roles in Trophoblast Life Cycle and Angiogenesis

Ball, M., Carmody, M., Wynne, F., Dockery, P., Aigner, A. M., Cameron, I., Higgins, J., Smith, S. D., Aplin, J., & Moore, T. (2009) · Placenta · doi:10.1016/j.placenta.2009.05.001 · Cited by 36 · see citing works

Involvement of Pleiotrophin in CNTF-mediated differentiation of the late retinal progenitor cells

Roger, J. E., Brajeul, V., Thomasseau, S., Hienola, A., Sahel, J., Guillonneau, X., & Goureau, O. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.07.003 · Cited by 34 · see citing works

Striatal Pleiotrophin Overexpression Provides Functional and Morphological Neuroprotection in the 6-Hydroxydopamine Model

Gombash, S. E., Lipton, J. W., Collier, T. J., Madhavan, L., Steece‐Collier, K., Cole-Strauss, A., Terpstra, B. T., Spieles-Engemann, A. L., Daley, B. F., Wohlgenant, S. L., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2011.216 · Cited by 33 · see citing works

Structure of Pleiotrophin- and Hepatocyte Growth Factor-binding Sulfated Hexasaccharide Determined by Biochemical and Computational Approaches

Li, F., Nandini, C., Hattori, T., Bao, X., Murayama, D., Nakamura, T., Fukushima, N., & Sugahara, K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.118703 · Cited by 33 · see citing works

Pleiotrophin promotes perineural invasion in pancreatic cancer

Yao, J. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i39.6555 · Cited by 33 · see citing works

Neuroprotective potential of pleiotrophin overexpression in the striatonigral pathway compared with overexpression in both the striatonigral and nigrostriatal pathways

Gombash, S. E., Manfredsson, F. P., Mandel, R. J., Collier, T. J., Fischer, D. L., Kemp, C. J., Kuhn, N. C., Wohlgenant, S. L., Fleming, S. M., & Sortwell, C. E. (2014) · Gene Therapy · doi:10.1038/gt.2014.42 · Cited by 31 · see citing works

The sulfation of biomimetic glycosaminoglycan substrates controls binding of growth factors and subsequent neural and glial cell growth

Malaeb, W., Bahmad, H. F., Abou-Kheir, W. G., & Mhanna, R. (2019) · Biomaterials Science · doi:10.1039/c9bm00964g · Cited by 31 · see citing works

What Else Can ‘Heparin’ Do?

Lindahl, U. (1999) · Pathophysiology of Haemostasis and Thrombosis · doi:10.1159/000054111 · Cited by 31 · see citing works

Molecular mechanisms of optic axon guidance

Inatani, M. (2005) · Die Naturwissenschaften · doi:10.1007/s00114-005-0042-5 · Cited by 30 · see citing works

Interaction of soluble and surface‐bound heparin binding growth‐associated molecule with heparin

Fath, M. A., VanderNoot, V. A., Kilpeläinen, I., Kinnunen, T. K., Rauvala, H., & Linhardt, R. J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00785-1 · Cited by 30 · see citing works

Endothelial Cell Proliferation Induced by HARP: Implication of N or C Terminal Peptides

Papadimitriou, Ε., Héroult, M., Courty, J., Polykratis, A., Stergiou, C., & Katsoris, P. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3126 · Cited by 30 · see citing works

The role of syndecans in the regulation of body weight and synaptic plasticity

Reizes, O., Benoit, S. C., & Clegg, D. J. (2007) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.06.011 · Cited by 29 · see citing works

Pleiotrophin and peripheral nerve injury

Li, J., Jianghai, C., Liu, J., & Kang, H. (2009) · Neurosurgical Review · doi:10.1007/s10143-009-0202-8 · Cited by 27 · see citing works

Combinatorial Roles of Heparan Sulfate Proteoglycans and Heparan Sulfates in Caenorhabditis elegans Neural Development

Kinnunen, T. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102919 · Cited by 26 · see citing works

Increased synthesis of heparin affin regulatory peptide in the perforant path lesioned mouse hippocampal formation

Poulsen, F. R., Lagord, C., Courty, J., Pedersen, E. B., Barritault, D., & Finsen, B. R. (2000) · Experimental Brain Research · doi:10.1007/s002210000536 · Cited by 25 · see citing works

Cloning and characterization of human syndecan‐3*

Berndt, C., Casaroli-Marano, R. P., Vilaró, S., & Reina, M. (2001) · Journal of Cellular Biochemistry · doi:10.1002/jcb.1119 · Cited by 25 · see citing works

Spatiotemporal expression patterns of N-syndecan, a transmembrane heparan sulfate proteoglycan, in developing retina.

Inatani, M., Honjo, M., Oohira, A., Kido, N., Otori, Y., Tano, Y., Honda, Y., & Tanihara, H. (2002) · PubMed · Cited by 21 · see citing works

Nitric Oxide a new player in L-DOPA-induced dyskinesia

Del-Bel, E. (2015) · Frontiers in Bioscience-Elite · doi:10.2741/e726 · Cited by 20 · see citing works

Pleiotrophin Regulates Bone Morphogenetic Protein (BMP)-Induced Ectopic Osteogenesis

Sato, Y., Takita, H., Ohata, N., Tamura, M., & Kuboki, Y. (2002) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003178 · Cited by 20 · see citing works

Glycosaminoglycans Promote HARP/PTN Dimerization

Bernard‐Pierrot, I., Héroult, M., Lemaı̂tre, G., Barritault, D., Courty, J., & Milhiet, P. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1835 · Cited by 20 · see citing works

Midkine binds specifically to sulfatide

Kurosawa, N., Kadomatsu, K., Ikematsu, S., Sakuma, S., Kimura, T., & Muramatsu, T. (2000) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2000.01005.x · Cited by 18 · see citing works

Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome

Brandebura, A. N., Paumier, A., Asbell, Q. N., Tao, T., Micael, M. K. B., Sanchez, S., & Allen, N. J. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116300 · Cited by 17 · see citing works

Gene delivery to overcome astrocyte inhibition of axonal growth: An in vitro Model of the glial scar

Tuinstra, H. M., Ducommun, M. M., Briley, W. E., & Shea, L. D. (2012) · Biotechnology and Bioengineering · doi:10.1002/bit.24750 · Cited by 17 · see citing works

A molecular recognition paradigm: promiscuity associated with the ligand-receptor interactions of the activin members of the TGF-β superfamily

Keah, H. H., & Hearn, M. T. W. (2005) · Journal of Molecular Recognition · doi:10.1002/jmr.715 · Cited by 17 · see citing works

Purification and characterization of heparan sulphate proteoglycan from bovine brain

Park, Y., Yu, G., Günay, N. S., & Linhardt, R. J. (1999) · Biochemical Journal · doi:10.1042/bj3440723 · Cited by 17 · see citing works

A Biocompatible Interface for the Geometrical Guidance of Central Neuronsin Vitro

Matsuzawa, M., Kobayashi, K., Sugioka, K., & Knoll, W. (1998) · Journal of Colloid and Interface Science · doi:10.1006/jcis.1998.5409 · Cited by 16 · see citing works

Syndecan‐2 expression enhances adhesion and proliferation of stably transfected Swiss 3T3 cells

Villena, J., Berndt, C., Granés, F., Reina, M., & Vilaró, S. (2003) · Cell Biology International · doi:10.1016/j.cellbi.2003.09.004 · Cited by 16 · see citing works

Upregulated expression of N-syndecan, a transmembrane heparan sulfate proteoglycan, in differentiated neural stem cells

Inatani, M., Haruta, M., Honjo, M., Oohira, A., Kido, N., Takahashi, M., Honda, Y., & Tanihara, H. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02856-6 · Cited by 16 · see citing works

The RF plasma polymer of lysine and the growth of human nerve cells on its surface

Feng, X., Zhang, J., Xie, H., Qun-hua, H., Huang, Q., & Liu, W. (2003) · Surface and Coatings Technology · doi:10.1016/s0257-8972(03)00246-9 · Cited by 15 · see citing works

Regulation of mRNA localization by transmembrane signalling: Local interaction of HB-GAM (heparin-binding growth-associated molecule) with the cell surface localizes β-actin mRNA

Fages, C., Kaksonen, M., Kinnunen, T. K., Punnonen, E., & Rauvala, H. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.20.3073 · Cited by 14 · see citing works

Characterization of syndecan-4 expression in 3T3-F442A mouse adipocytes: link between syndecan-4 induction and cell proliferation.

Landry, R., Rioux, V., & Bensadoun, A. (2001) · PubMed · Cited by 13 · see citing works

Upregulation of HARP during in vitro myogenesis and rat soleus muscle regeneration

Caruelle, D., Mazouzi, Z., Husmann, I., Delbé, J., Duchesnay, A., Gautron, J., Martelly, I., & Courty, J. (2004) · Journal of Muscle Research and Cell Motility · doi:10.1023/b:jure.0000021387.92378.2e · Cited by 12 · see citing works

Influence of cytoplasmic deletions on the filopodia‐inducing effect of syndecan‐3

Berndt, C., Montañez, E., Villena, J., Fabre, M., Vilaró, S., & Reina, M. (2004) · Cell Biology International · doi:10.1016/j.cellbi.2004.08.003 · Cited by 12 · see citing works

Effect of pleiotrophin on glutamate‐induced neurotoxicity in cultured hippocampal neurons

Asai, H., Morita, S., & Miyata, S. (2011) · Cell Biochemistry and Function · doi:10.1002/cbf.1802 · Cited by 11 · see citing works

Pleiotrophin-Loaded Mesoporous Silica Nanoparticles as a Possible Treatment for Osteoporosis

Lozano, D., Leiva, B., Gómez-Escalonilla, I., Portal‐Núñez, S., Gortázar, A. R., Manzano, M., & Vallet‐Regí, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020658 · Cited by 10 · see citing works

Molecular dynamics-based descriptors of 3-O-Sulfated Heparan sulfate as contributors of protein binding specificity

Danielsson, A., Kogut, M. M., Maszota‐Zieleniak, M., Chopra, P., Boons, G., & Samsonov, S. A. (2022) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2022.107716 · Cited by 10 · see citing works

The survival promoting peptide Y-P30 promotes cellular migration

Dash-Wagh, S., Neumann, J. R., Veitinger, S., Grote-Westrick, C., Landgraf, P., Pape, H., Kreutz, M. R., von Holst, A., & Wahle, P. (2011) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2011.07.005 · Cited by 10 · see citing works

Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3).

Raulo, E., Chernousov, M. A., Carey, D., Nolo, R. M., & Rauvala, H. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99975-8 · Cited by 284 · see citing works

N‐Syndecan and HB‐GAM (Heparin‐Binding Growth‐Associated Molecule) associate with early axonal tracts in the rat brain

Kinnunen, A., Kinnunen, T. K., Kaksonen, M., Nolo, R. M., Panula, P., & Rauvala, H. (1998) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1998.00082.x · Cited by 75 · see citing works

Heparan sulphate and HB‐GAM (heparin‐binding rowth‐associated molecule) in the development of the thalamocortical pathway of rat brain

Kinnunen, A., Niemi, M., Kinnunen, T. K., Kaksonen, M., Nolo, R. M., & Rauvala, H. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00457.x · Cited by 47 · see citing works

S5.7 Identification of a cell surface heparan-sulfate proteoglycan involved in HB-GAM (heparin-binding growth-associated molecule)-induced axon outgrowth

Raulo, E., Nolo, R. M., & Rauvala, H. (1993) · Glycoconjugate Journal · doi:10.1007/bf01209903

HB-GAM (HEPARIN-BINDING GROWTH-ASSOCIATED MOLECULE) AND HEPARIN-TYPE GLYCANS IN THE DEVELOPMENT AND PLASTICITY OF NEURON-TARGET CONTACTS

Rauvala, H. (1997) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00007-5 · Cited by 106 · see citing works