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cDNA Cloning and Characterization of the Human Interleukin 13 Receptor α Chain
Open accessAbstract
We have cloned cDNAs corresponding to the human interleukin 13 receptor alpha chain (IL-13Ralpha). The protein has 76% homology to murine IL-13Ralpha, with 95% amino acid identity in the cytoplasmic domain. Only weak IL-13 binding activity was found in cells transfected with only IL-13Ralpha; however, the combination of both IL-13Ralpha and IL-4Ralpha resulted in substantial binding activity, with a Kd of approximately 400 pM, indicating that both chains are essential components of the IL-13 receptor. Whereas IL-13Ralpha serves as an alternative accessory protein to the common cytokine receptor gamma chain (gammac) for IL-4 signaling, it could not replace the function of gammac in allowing enhanced IL-2 binding activity. Nevertheless, the overall size and length of the cytoplasmic domain of IL-13Ralpha and gammac are similar, and like gammac, IL-13Ralpha is located on chromosome X.
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Citations
Cited by
The IL-4 receptor: signaling mechanisms and biologic functions
Nelms, K., Keegan, A. D., Zamorano, J., Ryan, J. J., & Paul, W. E. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.701 · Cited by 1,545
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 958
Interleukin‐13 in asthma pathogenesis
Wills‐Karp, M. (2004) · Immunological Reviews · doi:10.1111/j.0105-2896.2004.00215.x · Cited by 683
Molecular and Structural Basis of Cytokine Receptor Pleiotropy in the Interleukin-4/13 System
LaPorte, S. L., Juo, Z. S., Vaclavikova, J., Colf, L. A., Qi, X., Heller, N. M., Keegan, A. D., & Garcia, K. C. (2008) · Cell · doi:10.1016/j.cell.2007.12.030 · Cited by 517
Structural Biology of Shared Cytokine Receptors
Wang, X., Lupardus, P., LaPorte, S. L., & Garcia, K. C. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090616 · Cited by 408
Metadata
- Authors
- Aman, M. J., Tayebi, N., Obiri, N. I., Puri, R. K., Modi, W. S., & Leonard, W. J.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-11
- Volume
- 271
- Issue
- 46
- Pages
- 29265-29270
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2012738581
- Cited by
- 281
- References
- 0
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Aman, M. J., Tayebi, N., Obiri, N. I., Puri, R. K., Modi, W. S., & Leonard, W. J. (1996). cDNA Cloning and Characterization of the Human Interleukin 13 Receptor α Chain. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.46.29265
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