The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Transcriptional Activation of the Human p21 Gene by Retinoic Acid Receptor
Open accessAbstract
We reported previously that the induced differentiation of the myelomonocytic cell line U937 by vitamin D3 is facilitated by the transcriptional induction of the p21(WAF1/CIP1) gene by the vitamin D3 receptor (Liu, M., Lee, M.-H., Cohen, M., and Freedman, L. P. (1996) Genes Dev. 10, 143-153). Retinoic acid (RA), a physiological metabolite of vitamin A, is also a potent inducer of differentiation of several cell types, including myeloid leukemic cells. Like vitamin D3, RA acts through a subfamily of nuclear hormone receptors, RARs and RXRs (retinoid X receptors), which regulate the expression of target genes by binding to specific DNA elements and modulating transcription initiation. In this report we demonstrate that the gene encoding p21 is also a RA-responsive target gene, and we describe a functional RA response element in this gene's promoter which is required to confer RA induction through RAR.RXR heterodimers. These results correlate the RA induction of monocytic differentiation of U937 cells with the transcriptional activation of the p21 gene and suggest a role for this cyclin/cyclin-dependent kinase complex inhibitor in facilitating this differentiation pathway.
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Cites
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Cited by
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Transcriptional Regulation of the p21(WAF1/CIP1)Gene
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Role of PML in Cell Growth and the Retinoic Acid Pathway
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RAR and RXR modulation in cancer and metabolic disease
Altucci, L., Leibowitz, M. D., Ogilvie, K. M., de Lera, A. R., & Gronemeyer, H. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2397 · Cited by 517
The Human Tumor Antigen PRAME Is a Dominant Repressor of Retinoic Acid Receptor Signaling
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Metadata
- Authors
- Liu, M., Iavarone, A., & Freedman, L. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 271
- Issue
- 49
- Pages
- 31723-31728
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2024868532
- Cited by
- 301
- References
- 34
- FWCI
- 7.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Liu, M., Iavarone, A., & Freedman, L. P. (1996). Transcriptional Activation of the Human p21 Gene by Retinoic Acid Receptor. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.49.31723
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
