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IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP
Open accessAbstract
A novel member of the interleukin-1 receptor family has been cloned by polymerase chain reaction using degenerate oligonucleotide primers derived from regions of sequence conservation, using as template a yeast artificial chromosome known to contain both interleukin-1 (IL-1) receptors and T1/ST2. The new receptor, called IL-1 receptor-related protein or IL-1Rrp, fails to bind any of the known IL-1 ligands. A chimeric receptor, in which the IL-1Rrp cytoplasmic domain is fused to the extracellular and transmembrane regions of the IL-1 receptor, responds to IL-1 following transfection into COS cells by activation of NFkappaB and induction of IL-8 promoter function.
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Citations
Cited by
Immunological and inflammatory functions of the interleukin-1 family
Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466
Interleukin-18 Regulates Both Th1 and Th2 Responses
Nakanishi, K., Yoshimoto, T., Tsutsui, H., & Okamura, H. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.423 · Cited by 1,315
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297
MyD88: An Adapter That Recruits IRAK to the IL-1 Receptor Complex
Wesche, H., Henzel, W. J., Shillinglaw, W., Li, S., & Cao, Z. (1997) · Immunity · doi:10.1016/s1074-7613(00)80402-1 · Cited by 1,117
Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice
Takeda, K., Tsutsui, H., Yoshimoto, T., Adachi, O., Yoshida, N., Kishimoto, T., Okamura, H., Nakanishi, K., & Akira, S. (1998) · Immunity · doi:10.1016/s1074-7613(00)80543-9 · Cited by 911
Metadata
- Authors
- Parnet, P., Garka, K. E., Bonnert, T. P., Dower, S. K., & Sims, J. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-02
- Volume
- 271
- Issue
- 8
- Pages
- 3967-3970
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1995507251
- Cited by
- 223
- References
- 0
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP. https://app.cochat.ai/papers/10.1074/jbc.271.8.3967
- The paper
- Parnet, P., Garka, K. E., Bonnert, T. P., Dower, S. K., & Sims, J. E. (1996). IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleukin-1 Receptor and Its Homologues T1/ST2 and IL-1R AcP. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.8.3967
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
