The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis
Open accessAbstract
CD95 (Fas/APO-1) and tumor necrosis factor receptor-1 (TNFR-1) are related molecules that signal apoptosis. Recently, a number of novel binding proteins have been proposed to mediate the signaling of these death receptors. Here we report that an N-terminal truncation of one of these candidate signal transducers, FADD/MORT1, abrogates CD95-induced apoptosis, ceramide generation, and activation of the cell death protease Yama/CPP32. In addition, this dominant-negative derivative of FADD (FADD-DN) blocked TNF-induced apoptosis while not affecting NF- kappaB activation. FADD-DN bound both receptors, and in the case of CD95, it disrupted the assembly of a signaling complex. Taken together, our results functionally establish FADD as the apoptotic trigger of CD95 and TNFR-1.
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Cites
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
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The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
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Self-citationTewari, M., Quan, L. T., O'Rourke, K., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90541-3 · Cited by 2,367
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Self-citationThe TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
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Monoclonal Antibody-Mediated Tumor Regression by Induction of Apoptosis
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Cited by
Death Receptors: Signaling and Modulation
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Self-citationCaspases: the executioners of apoptosis
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Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Self-citationTwo CD95 (APO‐1/Fas) signaling pathways
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Metadata
- Authors
- Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O'Rourke, K., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., & Dixit, V. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1996-03
- Volume
- 271
- Issue
- 9
- Pages
- 4961-4965
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2029501678
- Cited by
- 767
- References
- 34
- FWCI
- 31.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis. https://app.cochat.ai/papers/10.1074/jbc.271.9.4961
- The paper
- Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O'Rourke, K., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., & Dixit, V. M. (1996). FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.271.9.4961
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
