Death Receptors: Signaling and Modulation

Caspases: Enemies Within

Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857 · see citing works

Apoptosis in the Pathogenesis and Treatment of Disease

Thompson, C. B. (1995) · Science · doi:10.1126/science.7878464 · Cited by 6,524 · see citing works

The Bcl-2 Protein Family: Arbiters of Cell Survival

Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,303 · see citing works

Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.

Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145 · see citing works

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

Beg, A. A., & Baltimore, D. (1996) · Science · doi:10.1126/science.274.5288.782 · Cited by 3,047 · see citing works

Identification and characterization of a new member of the TNF family that induces apoptosis

Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900 · see citing works

Programmed Cell Death in Animal Development

Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685 · see citing works

Mechanisms and Genes of Cellular Suicide

Steller, H. (1995) · Science · doi:10.1126/science.7878463 · Cited by 2,465 · see citing works

FADD, a novel death domain-containing protein, interacts with the death domain of fas and initiates apoptosis

Chinnaiyan, A. M., O'Rourke, K., Tewari, M., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90071-3 · Cited by 2,431 · see citing works

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

Tewari, M., Quan, L. T., O’Rourke, K. M., Desnoyers, S., Zeng, Z., Beidler, D. R., Poirier, G. G., Salvesen, G. S., & Dixit, V. M. (1995) · Cell · doi:10.1016/0092-8674(95)90541-3 · Cited by 2,367 · see citing works

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

Boldin, M. P., Goncharov, T. M., Goltseve, Y. V., & Wallach, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81265-9 · Cited by 2,292 · see citing works

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125 · see citing works

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042 · see citing works

The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation

Hsu, H., Xiong, J., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90070-5 · Cited by 2,024 · see citing works

TRADD–TRAF2 and TRADD–FADD Interactions Define Two Distinct TNF Receptor 1 Signal Transduction Pathways

Hsu, H., Shu, H., Pan, M., & Goeddel, D. V. (1996) · Cell · doi:10.1016/s0092-8674(00)80984-8 · Cited by 1,998 · see citing works

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937 · see citing works

The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death

Smith, C. A., Farrah, T., & Goodwin, R. G. (1994) · Cell · doi:10.1016/0092-8674(94)90372-7 · Cited by 1,909 · see citing works

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., & Karin, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80406-7 · Cited by 1,814 · see citing works

Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family

Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., & Ashkenazi, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12687 · Cited by 1,777 · see citing works

The Receptor for the Cytotoxic Ligand TRAIL

Pan, G., O’Rourke, K. M., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., & Dixit, V. M. (1997) · Science · doi:10.1126/science.276.5309.111 · Cited by 1,755 · see citing works

A Matter of Life and Cell Death

Evan, G. I., & Littlewood, T. D. (1998) · Science · doi:10.1126/science.281.5381.1317 · Cited by 1,515 · see citing works

Molecular thanatopsis: a discourse on the BCL2 family and cell death

Yang, E., & Korsmeyer, S. J. (1996) · Blood · doi:10.1182/blood.v88.2.386.bloodjournal882386 · Cited by 1,329 · see citing works

Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors

Thome, M., Schneider, P., Hofmann, K., Fickenscher, H., Meinl, E., Neipel, F., Mattmann, C., Burns, K., Bodmer, J.-L., Schröter, M., et al. (1997) · Nature · doi:10.1038/386517a0 · Cited by 1,316 · see citing works

A novel domain within the 55 kd TNF receptor signals cell death

Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290 · see citing works

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279 · see citing works

Melanoma Cell Expression of Fas(Apo-1/CD95) Ligand: Implications for Tumor Immune Escape

Hahne, M., Rimoldi, D., Schröter, M., Romero, P. J., Schreier, M. H., French, L. E., Schneider, P., Bornand, T., Fontana, A., Liénard, D., et al. (1996) · Science · doi:10.1126/science.274.5291.1363 · Cited by 1,236 · see citing works

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V. (1997) · Science · doi:10.1126/science.278.5339.866 · Cited by 1,183 · see citing works

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

Emery, J. G., McDonnell, P., Burke, M. B., Deen, K. C., Lyn, S. D., Silverman, C., Dul, E., Appelbaum, E. R., Eichman, C., DiPrinzio, R., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.23.14363 · Cited by 1,183 · see citing works

TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex

Hsu, H., Huang, J., Shu, H.-B., Baichwal, V., & Goeddel, D. V. (1996) · Immunity · doi:10.1016/s1074-7613(00)80252-6 · Cited by 1,182 · see citing works

Identification and Characterization of an IκB Kinase

Régnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., & Rothe, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80344-x · Cited by 1,176 · see citing works

C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2

Hengartner, M. O., & Horvitz, H. R. (1994) · Cell · doi:10.1016/0092-8674(94)90506-1 · Cited by 1,167 · see citing works

TRAIL‐R2: a novel apoptosis‐mediating receptor for TRAIL

Walczak, H., Degli‐Esposti, M. A., Johnson, R. S., Smolak, P. J., Waugh, J. Y., Boiani, N., Timour, M. S., Gerhart, M. J., Schooley, K. A., Smith, C. A., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.17.5386 · Cited by 1,130 · see citing works

KILLER/DR5 is a DNA damage–inducible p53–regulated death receptor gene

Wu, G. S., Burns, T. F., McDonald, E. R., Jiang, W., Meng, R., Krantz, I. D., Kao, G., Gan, D.-D., Zhou, J.-Y., Muschel, R. J., et al. (1997) · Nature Genetics · doi:10.1038/ng1097-141 · Cited by 1,081 · see citing works

Two TNF receptors

Tartaglia, L. A., & Goeddel, D. V. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90116-o · Cited by 1,043 · see citing works

An Induced Proximity Model for Caspase-8 Activation

Muzio, M., Stockwell, B. R., Stennicke, H. R., Salvesen, G. S., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.5.2926 · Cited by 1,023 · see citing works

Lymphocyte apoptosis induced by CD95 (APO–1/Fas) ligand–expressing tumor cells — A mechanism of immune evasion?

Strand, S., Hofmann, W. J., Hug, H., Müller, M., Otto, G., Strand, D. J., Mariani, S. M., Stremmel, W., Krammer, P. H., & Galle, P. R. (1996) · Nature Medicine · doi:10.1038/nm1296-1361 · Cited by 897 · see citing works

FADD: Essential for Embryo Development and Signaling from Some, But Not All, Inducers of Apoptosis

Yeh, W., de la Pompa, J. L., McCurrach, M. E., Shu, H., Elia, A., Shahinian, A., Ng, M. S. W., Wakeham, A. C., Khoo, W., Mitchell, K., et al. (1998) · Science · doi:10.1126/science.279.5358.1954 · Cited by 886 · see citing works

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

Yang, X., Khosravi‐Far, R., Chang, H. Y., & Baltimore, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80294-9 · Cited by 830 · see citing works

The Novel Receptor TRAIL-R4 Induces NF-κB and Protects against TRAIL-Mediated Apoptosis, yet Retains an Incomplete Death Domain

Degli‐Esposti, M. A., Dougall, W. C., Smolak, P. J., Waugh, J. Y., Smith, C. A., & Goodwin, R. G. (1997) · Immunity · doi:10.1016/s1074-7613(00)80399-4 · Cited by 815 · see citing works

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

Yeh, W., Shahinian, A., Speiser, D. E., Kraunus, J., Billia, F., Wakeham, A. C., de la Pompa, J. L., Ferrick, D. A., Hum, B., Iscove, N. N., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80391-x · Cited by 798 · see citing works

Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1

Zhang, J., Cado, D., Chen, A., Kabra, N., & Winoto, A. (1998) · Nature · doi:10.1038/32681 · Cited by 792 · see citing works

FADD/MORT1 Is a Common Mediator of CD95 (Fas/APO-1) and Tumor Necrosis Factor Receptor-induced Apoptosis

Chinnaiyan, A. M., Tepper, C. G., Seldin, M. F., O’Rourke, K. M., Kischkel, F. C., Hellbardt, S., Krammer, P. H., Peter, M. E., & Dixit, V. M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.9.4961 · Cited by 767 · see citing works

Death Receptor 5, a New Member of the TNFR Family, and DR4 Induce FADD-Dependent Apoptosis and Activate the NF-κB Pathway

Chaudhary, P. M., Eby, M. T., Jasmin, A., Bookwalter, A., Murray, J. M., & Hood, L. (1997) · Immunity · doi:10.1016/s1074-7613(00)80400-8 · Cited by 712 · see citing works

TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces Apoptosis

Chicheportiche, Y., Bourdon, P. R., Xu, H., Hsu, Y., Scott, H. S., Hession, C. A., Garcia, I., & Browning, J. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.51.32401 · Cited by 690 · see citing works

A novel receptor for Apo2L/TRAIL contains a truncated death domain

Marsters, S. A., Sheridan, J. P., Pitti, R. M., Huang, A. J. Y., Skubatch, M., Baldwin, D. T., Yuan, J., Gurney, A. L., Goddard, A. D., Godowski, P. J., et al. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00422-2 · Cited by 654 · see citing works

Signal Transduction by DR3, a Death Domain-Containing Receptor Related to TNFR-1 and CD95

Chinnaiyan, A. M., O’Rourke, K. M., Yu, G.-L., Lyons, R. H., Garg, M., Duan, D. R., Xing, L., Gentz, R., Ni, J., & Dixit, V. M. (1996) · Science · doi:10.1126/science.274.5289.990 · Cited by 653 · see citing works

Cloning and Characterization of TRAIL-R3, a Novel Member of the Emerging TRAIL Receptor Family

Degli‐Esposti, M. A., Smolak, P. J., Walczak, H., Waugh, J. Y., Huang, C.-P., DuBose, R. F., Goodwin, R. G., & Smith, C. A. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.7.1165 · Cited by 630 · see citing works

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

Chinnaiyan, A. M., O’Rourke, K. M., Lane, B. R., & Dixit, V. M. (1997) · Science · doi:10.1126/science.275.5303.1122 · Cited by 626 · see citing works

Identification and Molecular Cloning of Two Novel Receptors for the Cytotoxic Ligand TRAIL

MacFarlane, M., Ahmad, M., Srinivasula, S. M., Fernandes‐Alnemri, T., Cohen, G. M., & Alnemri, E. S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.25417 · Cited by 558 · see citing works

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

Song, H. Y., Régnier, C. H., Kirschning, C. J., Goeddel, D. V., & Rothe, M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9792 · Cited by 554 · see citing works

RIP mediates tumor necrosis factor receptor 1 activation of NF‐kappaB but not Fas/APO‐1‐initiated apoptosis.

Ting, A. T., Pimentel‐Muiños, F. X., & Seed, B. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01007.x · Cited by 550 · see citing works

RAIDD is a new 'death' adaptor molecule

Duan, H., & Dixit, V. M. (1997) · Nature · doi:10.1038/385086a0 · Cited by 550 · see citing works

The CARD domain: a new apoptotic signalling motif

Hofmann, K. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01043-8 · Cited by 537 · see citing works

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

Newton, K., Harris, A. W., Bath, M. L., Smith, K. G. C., & Strasser, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.3.706 · Cited by 499 · see citing works

Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas

Gruss, H., & Dower, S. (1995) · Blood · doi:10.1182/blood.v85.12.3378.bloodjournal85123378 · Cited by 457 · see citing works

Activation of SAPK/JNK by TNF Receptor 1 Through a Noncytotoxic TRAF2-Dependent Pathway

Natoli, G., Costanzo, A., Ianni, A., Templeton, D. J., Woodgett, J. R., Balsano, C., & Levrero, M. (1997) · Science · doi:10.1126/science.275.5297.200 · Cited by 452 · see citing works

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

Shu, H., Takeuchi, M., & Goeddel, D. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.24.13973 · Cited by 418 · see citing works

Casper Is a FADD- and Caspase-Related Inducer of Apoptosis

Shu, H., Halpin, D. R., & Goeddel, D. V. (1997) · Immunity · doi:10.1016/s1074-7613(00)80450-1 · Cited by 399 · see citing works

Self-association of the “Death Domains” of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects

Boldin, M., Mett, I. L., Varfolomeev, E. E., Chumakov, I., Shemer‐Avni, Y., Camonis, J., & Wallach, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.1.387 · Cited by 386 · see citing works

NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain

Huang, B., Eberstadt, M., Olejniczak, E. T., Meadows, R. P., & Fesik, S. W. (1996) · Nature · doi:10.1038/384638a0 · Cited by 385 · see citing works

I-FLICE, a Novel Inhibitor of Tumor Necrosis Factor Receptor-1- and CD-95-induced Apoptosis

Hu, S., Vincenz, C., Ni, J., Gentz, R., & Dixit, V. M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.28.17255 · Cited by 375 · see citing works

Early Activation of c-Jun N-terminal Kinase and p38 Kinase Regulate Cell Survival in Response to Tumor Necrosis Factor α

Roulston, A., Reinhard, C., Amiri, P., & Williams, L. T. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.17.10232 · Cited by 371 · see citing works

A death-domain-containing receptor that mediates apoptosis

Kitson, J., Raven, T., Jiang, Y., Goeddel, D. V., Giles, K. M., Pun, K., Grinham, C. J., Brown, R., & Farrow, S. N. (1996) · Nature · doi:10.1038/384372a0 · Cited by 335 · see citing works

TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL

Screaton, G. R., Mongkolsapaya, J., Xu, X., Cowper, A. E., McMichael, A. J., & Bell, J. I. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00297-1 · Cited by 325 · see citing works

TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling

Pan, G., Ni, J., Yu, G., Wei, Y.-F., & Dixit, V. M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00135-5 · Cited by 316 · see citing works

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

Spector, M. S., Desnoyers, S., Hoeppner, D. J., & Hengartner, M. O. (1997) · Nature · doi:10.1038/385653a0 · Cited by 304 · see citing works

NMR structure of the death domain of the p75 neurotrophin receptor

Liepinsh, E., Ilag, L. L., Otting, G., & Ibáñez, C. F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.16.4999 · Cited by 303 · see citing works

Characterization of two receptors for TRAIL1

Schneider, P., Bodmer, J.-L., Thome, M., Hofmann, K., Holler, N., & Tschopp, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01231-3 · Cited by 290 · see citing works

TRAMP, a Novel Apoptosis-Mediating Receptor with Sequence Homology to Tumor Necrosis Factor Receptor 1 and Fas(Apo-1/CD95)

Bodmer, J.-L., Burns, K., Schneider, P., Hofmann, K., Steiner, V., Thome, M., Bornand, T., Hahne, M., Schröter, M., Becker, K., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80244-7 · Cited by 262 · see citing works

Apo-3, a new member of the tumor necrosis factor receptor family, contains a death domain and activates apoptosis and NF-κB

Marsters, S. A., Sheridan, J. P., Donahue, C. J., Pitti, R. M., Gray, C. L., Goddard, A. D., Bauer, K. D., & Ashkenazi, A. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70791-4 · Cited by 252 · see citing works

CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP.

Ahmad, M., Srinivasula, S. M., Wang, L., Talanian, R. V., Litwack, G., Fernandes‐Alnemri, T., & Alnemri, E. S. (1997) · PubMed · Cited by 250 · see citing works

Modulation of amplitude and direction ofin vivo immune responses by co-administration of cytokine gene expression cassettes with DNA immunogens

Kim, J. J., Trivedi, N. N., Nottingham, L. K., Morrison, L. D., Tsai, A., Hu, Y., Mahalingam, S., Dang, K., Ahn, L., Doyle, N. K., et al. (1998) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199803)28:03 · Cited by 238 · see citing works

CAR1, a TNFR–Related Protein, Is a Cellular Receptor for Cytopathic Avian Leukosis–Sarcoma Viruses and Mediates Apoptosis

Brojatsch, J., Naughton, J., Rolls, M. M., Zingler, K., & Young, J. A. T. (1996) · Cell · doi:10.1016/s0092-8674(00)81992-3 · Cited by 233 · see citing works

LARD: A new lymphoid-specific death domain containing receptor regulated by alternative pre-mRNA splicing

Screaton, G. R., Xu, X.-N., Olsen, A. L., Cowper, A. E., Tan, R., McMichael, A. J., & Bell, J. I. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4615 · Cited by 210 · see citing works

Cell death: TRAIL and its receptors

Golstein, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)90000-1 · Cited by 195 · see citing works

Role of CED-4 in the activation of CED-3

Chinnaiyan, A. M., Chaudhary, D., O’Rourke, K. M., Koonin, E. V., & Dixit, V. M. (1997) · Nature · doi:10.1038/41913 · Cited by 194 · see citing works

Activation of apoptosis by Apo-2 ligand is independent of FADD but blocked by CrmA

Marsters, S. A., Pitti, R. M., Donahue, C. J., Ruppert, S., Bauer, K. D., & Ashkenazi, A. (1996) · Current Biology · doi:10.1016/s0960-9822(09)00456-4 · Cited by 194 · see citing works

Identification of a ligand for the death-domain-containing receptor Apo3

Marsters, S. A., Sheridan, J. P., Pitti, R. M., Brush, J., Goddard, A. D., & Ashkenazi, A. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70204-0 · Cited by 188 · see citing works

Apoptosis and the maintenance of homoeostasis in the immune system

Osborne, B. A. (1996) · Current Opinion in Immunology · doi:10.1016/s0952-7915(96)80063-x · Cited by 174 · see citing works

Caenorhabditis elegans CED-4 stimulates CED-3 processing and CED-3-induced

Seshagiri, S., & Miller, L. K. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00216-8 · Cited by 174 · see citing works

Interleukin 1β-converting Enzyme Related Proteases/Caspases Are Involved in TRAIL-induced Apoptosis of Myeloma and Leukemia Cells

Mariani, S. M., Matiba, B., Armandola, E. A., & Krammer, P. H. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.137.1.221 · Cited by 142 · see citing works

Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): a new receptor protecting lymphocytes from the death ligand TRAIL.

Mongkolsapaya, J., Cowper, A., Xu, X., Morris, G. M., McMichael, A. J., Bell, J. I., & Screaton, G. R. (1998) · PubMed · Cited by 140 · see citing works

A potential mechanism of "cross-talk" between the p55 tumor necrosis factor receptor and Fas/APO1: proteins binding to the death domains of the two receptors also bind to each other.

Varfolomeev, E. E., Boldin, M., Goncharov, T. M., & Wallach, D. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.3.1271 · Cited by 132 · see citing works

p53-dependent impairment of T-cell proliferation in FADD dominant-negative transgenic mice

Zörnig, M., Hueber, A., & Evan, G. I. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70182-4 · Cited by 120 · see citing works

Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL

Mongkolsapaya, J., Cowper, A. E., Xu, X., Morris, G. M., McMichael, A. J., Bell, J. I., & Screaton, G. R. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.1.3 · Cited by 116 · see citing works

Placing death under control

Wallach, D. (1997) · Nature · doi:10.1038/40516 · Cited by 101 · see citing works

Apoptosis: A Review of Programmed Cell Death

Elmore, S. (2007) · Toxicologic Pathology · doi:10.1080/01926230701320337 · Cited by 13,853 · see citing works

The biochemistry of apoptosis

Hengartner, M. O. (2000) · Nature · doi:10.1038/35037710 · Cited by 7,295 · see citing works

Caspases: Enemies Within

Thornberry, N. A., & Lazebnik, Y. A. (1998) · Science · doi:10.1126/science.281.5381.1312 · Cited by 6,857 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor

Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 6,535 · see citing works

The Bcl-2 Protein Family: Arbiters of Cell Survival

Adams, J. M., & Cory, S. (1998) · Science · doi:10.1126/science.281.5381.1322 · Cited by 5,303 · see citing works

Cell Death

Danial, N. N., & Korsmeyer, S. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00046-7 · Cited by 4,651 · see citing works

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686 · see citing works

The TNF and TNF Receptor Superfamilies

Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650 · see citing works

BCL-2 family members and the mitochondria in apoptosisPreprint

Gross, A., McDonnell, J. M., & Korsmeyer, S. J. (1999) · Genes & Development · doi:10.1101/gad.13.15.1899 · Cited by 3,623 · see citing works

Ischemic Cell Death in Brain Neurons

Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043 · see citing works

Role of reactive oxygen species (ROS) in apoptosis induction

Simon, H.-U., Haj-Yehia, A., & Levi-Schaffer, F. (2000) · Apoptosis · doi:10.1023/a:1009616228304 · Cited by 2,774 · see citing works

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738 · see citing works

Biochemical Pathways of Caspase Activation During Apoptosis

Budihardjo, I. I., Oliver, H., Lutter, M. L., Luo, X., & Wang, X. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.269 · Cited by 2,562 · see citing works

Untitled work

(2001) · PubMed · Cited by 2,381 · see citing works

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Nakano, K., & Vousden, K. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00214-3 · Cited by 2,315 · see citing works

Safety and antitumor activity of recombinant soluble Apo2 ligand

Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtrey, A. E., Hebert, A., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6926 · Cited by 2,213 · see citing works

Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis

Su, L.-J., Zhang, J.-H., Gomez, H., Murugan, R., Hong, X., Xu, D., Jiang, F., & Peng, Z.-Y. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/5080843 · Cited by 2,166 · see citing works

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,887 · see citing works

Apoptosis in cancer

Lowe, S. W., & Lin, A. W. (2000) · Carcinogenesis · doi:10.1093/carcin/21.3.485 · Cited by 1,867 · see citing works

Mechanisms of Caspase Activation and Inhibition during Apoptosis

Shi, Y. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00482-3 · Cited by 1,824 · see citing works

Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf

Mariathasan, S., Newton, K., Monack, D. M., Vucic, D., French, D. M., Lee, W. P., Roose-Girma, M., Erickson, S. L., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02664 · Cited by 1,822 · see citing works

The cellular and molecular basis of hyperthermia

Hildebrandt, B. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00179-2 · Cited by 1,714 · see citing works

Emergent Properties of Networks of Biological Signaling Pathways

Bhalla, U. S., & Iyengar, R. (1999) · Science · doi:10.1126/science.283.5400.381 · Cited by 1,686 · see citing works

Microglia as a source and target of cytokines

Hanisch, U. (2002) · Glia · doi:10.1002/glia.10161 · Cited by 1,645 · see citing works

Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis

Sinha, K., Das, J., Pal, P. B., & Sil, P. C. (2013) · Archives of Toxicology · doi:10.1007/s00204-013-1034-4 · Cited by 1,622 · see citing works

The role of apoptosis in response to photodynamic therapy: what, where, why, and how

Oleinick, N. L., Morris, R. L., & Belitchenko, I. (2002) · Photochemical & Photobiological Sciences · doi:10.1039/b108586g · Cited by 1,502 · see citing works

Cell Activation and Apoptosis by Bacterial Lipoproteins Through Toll-like Receptor-2

Aliprantis, A. O., Yang, R., Mark, M. R., Suggett, S., Devaux, B., Radolf, J. D., Klimpel, G. R., Godowski, P. J., & Zychlinsky, A. (1999) · Science · doi:10.1126/science.285.5428.736 · Cited by 1,463 · see citing works

The Bcl-2 family: roles in cell survival and oncogenesis

Cory, S., Huang, D. C. S., & Adams, J. M. (2003) · Oncogene · doi:10.1038/sj.onc.1207102 · Cited by 1,455 · see citing works

Morphologic and biochemical hallmarks of apoptosis

Saraste, A. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(99)00384-3 · Cited by 1,454 · see citing works

Assembly of Cell Regulatory Systems Through Protein Interaction Domains

Pawson, T. J., & Nash, P. (2003) · Science · doi:10.1126/science.1083653 · Cited by 1,403 · see citing works

Mechanisms of caspase activation

Boatright, K. M., & Salvesen, G. S. (2003) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2003.10.009 · Cited by 1,374 · see citing works

Apoptosis Signaling

Strasser, A., O’Connor, L., & Dixit, V. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.217 · Cited by 1,369 · see citing works

Cytochrome C -Mediated Apoptosis

Jiang, X., & Wang, X. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.073706 · Cited by 1,359 · see citing works

Targeting death and decoy receptors of the tumour-necrosis factor superfamily

Ashkenazi, A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc821 · Cited by 1,351 · see citing works

Overview of cell death signaling pathways

Jin, Z., & El‐Deiry, W. S. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1508 · Cited by 1,323 · see citing works

Molecular Imaging

Weissleder, R., & Mahmood, U. (2001) · Radiology · doi:10.1148/radiology.219.2.r01ma19316 · Cited by 1,315 · see citing works

Review: Environmental exposure to mercury and its toxicopathologic implications for public health

Tchounwou, P. B., Ayensu, W. K., Ninashvili, N., & Sutton, D. J. (2003) · Environmental Toxicology · doi:10.1002/tox.10116 · Cited by 1,294 · see citing works

Oxidative stress and apoptosis

Kannan, K., & Jain, S. K. (2000) · Pathophysiology · doi:10.1016/s0928-4680(00)00053-5 · Cited by 1,291 · see citing works

Apoptosis control by death and decoy receptors

Ashkenazi, A., & Dixit, V. M. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80034-9 · Cited by 1,281 · see citing works

Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease

Blum, D. L., Torch, S., Lambeng, N., Nissou, M.-F., Benabid, A., Sadoul, R., & Verna, J. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00003-x · Cited by 1,246 · see citing works

G1 cell-cycle control and cancer

Massagué, J. (2004) · Nature · doi:10.1038/nature03094 · Cited by 1,217 · see citing works

Control of apoptosis by Rel/NF-κB transcription factors

Barkett, M., & Gilmore, T. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203238 · Cited by 1,190 · see citing works

TNF? and the TNF receptor superfamily: Structure-function relationship(s)

Idriss, H. T., & Naismith, J. H. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20000801)50:3 · Cited by 1,175 · see citing works

Natural Killer Cells: Development, Maturation, and Clinical Utilization

Abel, A. M., Yang, C., Thakar, M. S., & Malarkannan, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01869 · Cited by 1,150 · see citing works

Apoptosis - the p53 network

Haupt, S., Berger, M., Goldberg, Z., & Haupt, Y. (2003) · Journal of Cell Science · doi:10.1242/jcs.00739 · Cited by 1,136 · see citing works

Executioner Caspase-3, -6, and -7 Perform Distinct, Non-redundant Roles during the Demolition Phase of Apoptosis

Slee, E. A., Adrain, C., & Martin, S. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008363200 · Cited by 1,118 · see citing works

Emerging Mechanisms and Disease Relevance of Ferroptosis

Stockwell, B. R., Jiang, X., & Gu, W. J. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.02.009 · Cited by 1,107 · see citing works

Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

Feldstein, A. E., Canbay, A., Angulo, P., Taniai, M., Burgart, L. J., Lindor, K. D., & Gores, G. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00907-7 · Cited by 1,085 · see citing works

NODs: intracellular proteins involved in inflammation and apoptosis

Inohara, N., & Núñez, G. (2003) · Nature reviews. Immunology · doi:10.1038/nri1086 · Cited by 1,063 · see citing works

Cell death

Newton, K., Strasser, A., Kayagaki, N., & Dixit, V. M. (2024) · Cell · doi:10.1016/j.cell.2023.11.044 · Cited by 1,029 · see citing works

Emerging connectivity of programmed cell death pathways and its physiological implications

Bedoui, S., Herold, M. J., & Strasser, A. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0270-8 · Cited by 986 · see citing works

Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease

Re, D. P. D., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019) · Physiological Reviews · doi:10.1152/physrev.00022.2018 · Cited by 979 · see citing works

Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5

Kischkel, F. C., Lawrence, D. A., Chuntharapai, A., Schow, P., Kim, K. J., & Ashkenazi, A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80212-5 · Cited by 975 · see citing works

The many roles of FAS receptor signaling in the immune system

Strasser, A., Jost, P. J., & Nagata, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.001 · Cited by 968 · see citing works

A Unified Model for Apical Caspase Activation

Boatright, K. M., Renatus, M., Scott, F. L., Sperandio, S., Shin, H., Pedersen, I. M., Ricci, J., Edris, W. A., Sutherlin, D. P., Green, D. R., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00051-0 · Cited by 963 · see citing works

Reactive oxygen species in tumor progression

Peter, S. F. (2005) · Frontiers in bioscience · doi:10.2741/1667 · Cited by 957 · see citing works

Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases

Wolf, B. B., & Green, D. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.29.20049 · Cited by 942 · see citing works

Caspase activation: The induced-proximity model

Salvesen, G. S., & Dixit, V. M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.10964 · Cited by 932 · see citing works

Drug-induced liver injury

Andrade, R. J., Chalasani, N., Bjornsson, E. S., Suzuki, A., Kullak-Ublick, G. A., Watkins, P. B., Devarbhavi, H. C., Merz, M., Lucena, M. I., Kaplowitz, N., et al. (2019) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0105-0 · Cited by 907 · see citing works

Apoptotic DNA Fragmentation

Nagata, S. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4834 · Cited by 906 · see citing works

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

Ashkenazi, A., Fairbrother, W. J., Leverson, J. D., & Souers, A. J. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.253 · Cited by 903 · see citing works

Cell Death Independent of Caspases: A Review

Bröker, L. E., Kruyt, F. A. E., & Giaccone, G. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2223 · Cited by 899 · see citing works

Proinflammatory Cytokines Disrupt Epithelial Barrier Function by Apoptosis-Independent Mechanisms

Bruewer, M., Luegering, A., Kucharzik, T. F., Parkos, C. A., Madara, J., Hopkins, A. M., & Nusrat, A. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.6164 · Cited by 897 · see citing works

Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin

Plotkin, L. I., Weinstein, R. S., Parfitt, A. M., Roberson, P. K., Manolagas, S. C., & Bellido, T. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6800 · Cited by 890 · see citing works

The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development

Kuan, C.-Y., Yang, D. D., Roy, D. R. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80727-8 · Cited by 889 · see citing works

Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis

Hwang, H. S., & Kim, H. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161125943 · Cited by 886 · see citing works

Mechanism of Action of Conventional and Targeted Anticancer Therapies: Reinstating Immunosurveillance

Zitvogel, L., Galluzzi, L., Smyth, M. J., & Kroemer, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.06.014 · Cited by 879 · see citing works

The protein structures that shape caspase activity, specificity, activation and inhibition

Fuentes‐Prior, P., & Salvesen, G. S. (2004) · Biochemical Journal · doi:10.1042/bj20041142 · Cited by 877 · see citing works

Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis

Valiente, M., Obenauf, A. C., Jin, X., Chen, Q., Zhang, X. H.-F., Lee, D. J., Chaft, J. E., Kris, M. G., Huse, J. T., Brogi, E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.040 · Cited by 871 · see citing works

TRAIL and apoptosis induction by TNF-family death receptors

Wang, S., & El‐Deiry, W. S. (2003) · Oncogene · doi:10.1038/sj.onc.1207232 · Cited by 869 · see citing works

More than one way to die: apoptosis, necrosis and reactive oxygen damage

Fiers, W. C., Beyaert, R., Declercq, W., & Vandenabeele, P. (1999) · Oncogene · doi:10.1038/sj.onc.1203249 · Cited by 858 · see citing works

A Domain in TNF Receptors That Mediates Ligand-Independent Receptor Assembly and Signaling

Chan, F. K.-M., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., & Lenardo, M. J. (2000) · Science · doi:10.1126/science.288.5475.2351 · Cited by 856 · see citing works

Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosisPreprint

Lin, Y., Devin, A., Rodriguez, Y., & Liu, Z.-G. (1999) · Genes & Development · doi:10.1101/gad.13.19.2514 · Cited by 835 · see citing works

Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis

Chawla-Sarkar, M., Lindner, D. J., Liu, Y.-F., Williams, B. R., Sen, G. C., Silverman, R. H., & Borden, E. C. (2003) · Apoptosis · doi:10.1023/a:1023668705040 · Cited by 829 · see citing works

The machinery of programmed cell death

Zimmermann, K. C., Bonzon, C., & Green, D. R. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00159-0 · Cited by 829 · see citing works

Viral Subversion of the Immune System

Tortorella, D., Gewurz, B. E., Furman, M. H., Schust, D. J., & Ploegh, H. L. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.861 · Cited by 828 · see citing works

CHOP Is Involved in Endoplasmic Reticulum Stress-induced Apoptosis by Enhancing DR5 Expression in Human Carcinoma Cells

Yamaguchi, H., & Wang, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406933200 · Cited by 825 · see citing works

Apoptosis and melanoma chemoresistance

Soengas, M. S., & Lowe, S. W. (2003) · Oncogene · doi:10.1038/sj.onc.1206454 · Cited by 822 · see citing works

Caspases and their substrates

Julien, O., & Wells, J. A. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.44 · Cited by 816 · see citing works

NF-κB Signals Induce the Expression of c-FLIP

Micheau, O., Lens, S. M. A., Gaide, O., Alevizopoulos, K., & Tschopp, J. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.16.5299-5305.2001 · Cited by 809 · see citing works

Regulation ofp53downstream genes

El‐Deiry, W. S. (1998) · Seminars in Cancer Biology · doi:10.1006/scbi.1998.0097 · Cited by 797 · see citing works

Death receptor-induced cell killing

Thorburn, A. M. (2003) · Cellular Signalling · doi:10.1016/j.cellsig.2003.08.007 · Cited by 787 · see citing works

Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer

Pitti, R. M., Marsters, S. A., Lawrence, D. A., Roy, M. A., Kischkel, F. C., Dowd, P., Huang, A. J. Y., Donahue, C. J., Sherwood, S. W., Baldwin, D. T., et al. (1998) · Nature · doi:10.1038/25387 · Cited by 775 · see citing works

Protein–protein interactions define specificity in signal transductionPreprint

Pawson, T. J., & Nash, P. (2000) · Genes & Development · doi:10.1101/gad.14.9.1027 · Cited by 775 · see citing works

Fas Ligand-Induced Apoptosis

Nagata, S. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.29 · Cited by 772 · see citing works

Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells

Takeda, K., Hayakawa, Y., Smyth, M. J., Kayagaki, N., Yamaguchi, N., Kakuta, S., Iwakura, Y., Yagita∥, H., & Okumura, K. (2001) · Nature Medicine · doi:10.1038/83416 · Cited by 771 · see citing works

Viruses and Apoptosis

Roulston, A., Marcellus, R. C., & Branton, P. E. (1999) · Annual Review of Microbiology · doi:10.1146/annurev.micro.53.1.577 · Cited by 757 · see citing works

Chemotherapy-Associated Oxidative Stress: Impact on Chemotherapeutic Effectiveness

Conklin, K. A. (2004) · Integrative Cancer Therapies · doi:10.1177/1534735404270335 · Cited by 752 · see citing works

Oxidative stress and apoptosis: Impact on cancer therapy

Ozben, T. (2007) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.20874 · Cited by 751 · see citing works

RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in Osteoclastogenesis

Nakagawa, N., Kinosaki, M., Yamaguchi, K., Shima, N., Yasuda, H., Yano, K., Morinaga, T., & Higashio, K. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9788 · Cited by 746 · see citing works

Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis

Matsuyama, S., Llopis, J. L., Deveraux, Q. L., Tsien, R. Y., & Reed, J. C. (2000) · Nature Cell Biology · doi:10.1038/35014006 · Cited by 740 · see citing works

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo

Fulda, S., Wick, W., Weller, M., & Debatin, K. (2002) · Nature Medicine · doi:10.1038/nm735 · Cited by 736 · see citing works

Role of JNK activation in apoptosis: A double-edged sword

Liu, J., & Lin, A. (2005) · Cell Research · doi:10.1038/sj.cr.7290262 · Cited by 736 · see citing works

Proteases for Cell Suicide: Functions and Regulation of Caspases

Chang, H. Y., & Yang, X. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.4.821-846.2000 · Cited by 736 · see citing works

Role of NF-κB in p53-mediated programmed cell death

Ryan, K. M., Ernst, M. K., Rice, N. R., & Vousden, K. H. (2000) · Nature · doi:10.1038/35009130 · Cited by 735 · see citing works

Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteins

Puthalakath, H., & Strasser, A. (2002) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400998 · Cited by 724 · see citing works

CD8+ T Cell Effector Mechanisms in Resistance to Infection

Harty, J. T., Tvinnereim, A., & White, D. W. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.275 · Cited by 721 · see citing works

Apoptosis and cancer: mutations within caspase genes

Ghavami, S., Hashemi, M. M., Ande, S. R., Yeganeh, B., Xiao, W., Eshraghi, M., Bus, C., Kadkhoda, K., Wiecheć, E., Halayko, A. J., et al. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2009.066944 · Cited by 712 · see citing works

Pediatric acute lymphoblastic leukemia

Inaba, H., & Mullighan, C. G. (2020) · Haematologica · doi:10.3324/haematol.2020.247031 · Cited by 710 · see citing works

Apoptosis control by death and decoy receptors

Ashkenazi, A., & Dixit, V. M. (1999) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(99)80034-9 · Cited by 1,281 · see citing works

Nature and Science, 3(2), 2005, Ma, et al, Apoptosis

Ma, H., Shieh, K.-J., Chen, G., & Apoptosis, D. S. (2013)

Death Receptors and Cognate Ligands in Cancer

Kalthoff, H. (2009) · Results and problems in cell differentiation · doi:10.1007/978-3-642-03045-1 · Cited by 16 · see citing works

The Death Receptors

Peter, M. E., Scaffidi, C., Medema, J. P., Kischkel, F. C., & Krammer, P. H. (1999) · Results and problems in cell differentiation · doi:10.1007/978-3-540-69184-6_3 · Cited by 82 · see citing works

Death receptors couple to both cell proliferation and apoptosis

Budd, R. C. (2002) · Journal of Clinical Investigation · doi:10.1172/jci200215077 · Cited by 8 · see citing works