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Molecular Cloning and Expression of a Chloride Ion Channel of Cell Nuclei
Open accessAbstract
Ion channels are known to be present on the plasma membrane of virtually all cells and have been found on the membranes of various intracellular organelles. However, until recently they were believed not to occur at the nuclear membrane. In this study we describe the molecular cloning and characterization of a nuclear ion channel protein, designated nuclear chloride channel-27 (NCC27), from the human myelomonocytic cell line, U937. NCC27 is a novel chloride ion channel protein that was found to localize principally to the cell nucleus. Its only known homologue is a bovine chloride ion channel protein (p64) believed to localize to internal organelles. NCC27 therefore represents the first human member of a new class of organellar chloride ion channel proteins.
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Cited by
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Molecular Structure and Physiological Function of Chloride Channels
Jentsch, T. J., Stein, V., Weinreich, F., & Zdebik, A. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00029.2001 · Cited by 1,256
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Fairlie, W. D., Moore, A. G., Bauskin, A. R., Russell, P. K., Zhang, H.-P., & Breit, S. N. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.1.2 · Cited by 265
Self-citationLerner, L., Hayes, T. G., Tao, N., Krieger, B., Feng, B., Wu, Z., Nicoletti, R., Chiu, M. I., Gyuris, J., & Garcia, J. M. (2015) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12033 · Cited by 208
Setti, M., Osti, D., Richichi, C., Ortensi, B., Del Bene, M., Fornasari, L., Beznoussenko, G., Mironov, A., Rappa, G., Cuomo, A., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5105 · Cited by 93
Metadata
- Authors
- Valenzuela, S. M., Martin, D. K., Por, S. B., Robbins, J. M., Warton, K., Bootcov, M. R., Schofield, P. R., Campbell, T. J., & Breit, S. N.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 272
- Issue
- 19
- Pages
- 12575-12582
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2079593971
- Cited by
- 210
- References
- 0
- FWCI
- 3.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Valenzuela, S. M., Martin, D. K., Por, S. B., Robbins, J. M., Warton, K., Bootcov, M. R., Schofield, P. R., Campbell, T. J., & Breit, S. N. (1997). Molecular Cloning and Expression of a Chloride Ion Channel of Cell Nuclei. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.19.12575
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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