The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
MIC-1 is a novel TGF-β superfamily cytokine associated with macrophage activation
Abstract
As part of a study to identify novel genes associated with macrophage activation, we have cloned a new member of the transforming growth factor β (TGF-β) superfamily designated macrophage inhibitory cytokine 1 (MIC-1). MIC-1 is synthesized as a 62-kDa intracellular protein, which, after cleavage by a furin like protease, is secreted as a 25-kDa disulfide-linked dimeric protein. Sequence analysis indicates that it does not cluster within any existing TGF-β families, suggesting it may be the first member of a new grouping within the TGF-β superfamily. Tissue Northern blots show that MIC-1 transcripts are only found abundantly in placenta, although smaller amounts are seen in a limited number of other adult and fetal tissues. MIC-1 is not expressed in resting macrophages but is induced by a number of different activation agents, including phorbol myristate acetate, interleukin 1, tumor necrosis factor α, and macrophage colony-stimulating factor but not by lipopolysaccharide or interferon-γ. We have hypothesized that it may be an autocrine inhibitor of macrophage activation but its major biological role is still uncertain. J. Leukoc. Biol. 65: 2–5; 1999.
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Molecular Cloning and Expression of a Chloride Ion Channel of Cell Nuclei
Valenzuela, S. M., Martin, D. K., Por, S. B., Robbins, J. M., Warton, K., Bootcov, M. R., Schofield, P. R., Campbell, T. J., & Breit, S. N. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.19.12575 · Cited by 210
Self-citationEvolution of the transforming growth factor-beta superfamily
Burt, D. W., & Law, A. (1994) · Progress in Growth Factor Research · doi:10.1016/0955-2235(94)90020-5 · Cited by 126
Human cDNA Encoding a Novel TGF- Superfamily Protein Highly Expressed in Placenta
Yokoyama-Kobayashi, M., Saeki, M., Sekine, S., & Kato, S. (1997) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021798 · Cited by 116
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Borner, T., Shaulson, E. D., Ghidewon, M. Y., Barnett, A. B., Horn, C. C., Doyle, R. P., Grill, H. J., Hayes, M. R., & De Jonghe, B. C. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.12.004 · Cited by 255
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Metadata
- Authors
- Fairlie, W. D., Moore, A. G., Bauskin, A. R., Russell, P. K., Zhang, H.-P., & Breit, S. N.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 1999-01-01
- Volume
- 65
- Issue
- 1
- Pages
- 2-5
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2141647862
- Cited by
- 265
- References
- 3
- FWCI
- 1.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fairlie, W. D., Moore, A. G., Bauskin, A. R., Russell, P. K., Zhang, H.-P., & Breit, S. N. (1999). MIC-1 is a novel TGF-β superfamily cytokine associated with macrophage activation. Journal of Leukocyte Biology. https://doi.org/10.1002/jlb.65.1.2
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
