Ferritin Is a Developmentally Regulated Nuclear Protein of Avian Corneal Epithelial Cells
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Previously, we generated monoclonal antibodies against chicken corneal cells (Zak, N. B., and Linsenmayer, T. F. (1983) Dev. Biol. 99, 373). We have now observed that one group of these antibodies reacts with a developmentally regulated component of corneal epithelial cell nuclei. This component is the heavy chain of ferritin, as determined by analyses of immunoisolated cDNA clones and immunoblotting of the protein. Immunoblotting also suggests that the nuclear ferritin may be in a supramolecular form that is similar to the iron-binding ferritin complex found in the cytoplasm of many cells. In vitro cultures and transfection studies show that the nuclear localization depends predominantly on cell type but can be altered by the in vitro environment. The appearance of nuclear ferritin is at least partially under translational regulation, as is known to be true for the cytoplasmic form of the molecule. The tissue and developmental distributions of the mRNA for the molecule are much more extensive than the protein itself, and the removal of iron from cultures of corneal epithelial cells with the iron chelator deferoxamine prevents the appearance of nuclear ferritin. At present the functional role(s) of nuclear ferritin remain unknown, but previous studies on cytoplasmic ferritin raise the possibility that it prevents damage due to free radical generation ("oxidative stress") by sequestering iron. Although it remains to be tested whether nuclear ferritin prevents oxidative damage, we find this an attractive possibility. Since the corneal epithelium is transparent and is constantly exposed to free radical-generating UV light, it is possible that the cells of this tissue have evolved a specialized mechanism to prevent oxidative damage to their nuclear components.
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Inhibition of nuclear ferritin expression by deferoxamine in corneal epithelial cells resulted in sensitization of the cells to UV-induced DNA damage.
“the inhibition of nuclear ferritin expression by the iron chelator deferoxamine (this may also decrease cytoplasmic ferritin expression) in corneal epithelial cells resulted in the sensitization of the cells to UV-induced DNA damage (32).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [32]
Nuclear ferritin prevents iron-mediated ROS production, thereby protecting DNA from strand damage in corneal epithelial cells.
“nuclear ferritin acts like cytoplasmic ferritin, in that it prevents iron-mediated ROS production, thereby protecting DNA from strand damage (32).”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [32]
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Wu, J., Sowińska‐Seidler, A., Huang, X., Klein, C. B., Pelle, E., & Frenkel, K. (2012) · BioMetals · doi:10.1007/s10534-012-9559-1 · Cited by 5 · see citing works
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Linsenmayer, T. F., Beazley, K. E., Cai, C. X., Canner, J. P., Fitch, J. M., Kubilus, J. K., Millholland, J. M., Nurminskaya, M., Talbot, C. J., & Zak, N. B. (2014) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-4939-1935-2_3 · Cited by 3 · see citing works
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Cloning of Melanin Concentrating Hormone cDNA Gene from Olive Flounder (Paralichthys olivaceus)
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Li, J., Li, A., Wei, Z., Lin, Z., Lv, L., Yao, H., & Dong, Y. (2026) · Biological Trace Element Research · doi:10.1007/s12011-026-05267-3
- Authors
- Cai, C. X., Birk, D. E., & Linsenmayer, T. F.
- Affiliations
- Tufts University (US)
- Corresponding author
- Linsenmayer, Thomas F.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 272
- Issue
- 19
- Pages
- 12831-12839
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2031230073
- Cited by
- 55
- References
- 52
- Citations by year
- 2026: 1 · 2024: 1 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 1
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY005129, EY05191, EY05129)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- FTH1, corneal epithelial cells, chickens, developmental regulation, iron sequestration, oxidative stress, free radicals, deferoxamine, translational regulation, monoclonal antibodies, nuclear localization, cornea
- MeSH terms
- Animals, Antibodies, Monoclonal, Chickens, Cornea, Epithelium, Ferritins, Microscopy, Fluorescence, Nuclear Proteins, Protein Conformation, Ultraviolet Rays, Reactive Oxygen Species, DNA, Complementary
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