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Hyaluronan Synthases
Open accessAbstract
In 1934, Meyer and Palmer isolated a novel, highMr glycosaminoglycan from the vitreous of the eye (1). They showed that this substance contained a hexuronic acid, an amino sugar, and no sulfoesters and proposed the name hyaluronic acid (hyaluronan, HA),1 from the Greekhyaloid (vitreous) and uronic acid. It took 20 years before Weissmann and Meyer (2) finally established the precise structure of the repeating disaccharide unit of hyaluronic acid (GlcAβ(1→3)GlcNAcβ(1→4)). The number of repeating disaccharides in an HA molecule can exceed 30,000, a Mr>107.
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Cited by
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Hyaluronan: from extracellular glue to pericellular cue
Toole, B. P. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1391 · Cited by 2,125
Hyaluronan as an Immune Regulator in Human Diseases
Jiang, D., Liang, J., & Noble, P. W. (2011) · Physiological Reviews · doi:10.1152/physrev.00052.2009 · Cited by 1,060
Hyaluronic acid: A key molecule in skin aging
Papakonstantinou, E., Roth, M., & Karakiulakis, G. (2012) · Dermato-Endocrinology · doi:10.4161/derm.21923 · Cited by 1,031
Three isoforms of mammalian hyaluronan synthases have distinct enzymatic properties
Itano, N., Sawai, T., Yoshida, M., Lenas, P., Yamada, Y., Imagawa, M., Shinomura, T., Hamaguchi, M., Yoshida, Y., Ohnuki, Y., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.35.25085 · Cited by 901
Metadata
- Authors
- Weigel, P. H., Hascall, V. C., & Tammi, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-05
- Volume
- 272
- Issue
- 22
- Pages
- 13997-14000
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W4244406676
- Cited by
- 628
- References
- 0
- FWCI
- 7.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Weigel, P. H., Hascall, V. C., & Tammi, M. (1997). Hyaluronan Synthases. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.22.13997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
