Hyaluronan: from extracellular glue to pericellular cue
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HA is a glycosaminoglycan that regulates lubrication through binding of water, and is responsible for various cellular processes related to movement and maturation.
“Another major component of the ECM is HA, a glycosaminoglycan (GAG) that regulates lubrication through the binding of water, and is responsible for various cellular processes related to movement and maturation.”
From Unraveling and Harnessing the Immune Response at the Cell–Biomaterial Interface for Tissue Engineering Purposes (2024) · cites this paper as [259]
Hyaluronan synthases may act as anchor molecules for perineuronal nets because they retain the growing hyaluronan polymer while synthesizing and extruding it.
“Furthermore, because HASs retain the growing hyaluronan polymer while synthesizing and extruding it from the cell surface (Toole, 2004), they might act as anchor molecules for the PNN.”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Toole, 2004
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- Authors
- Toole, B. P.
- Affiliations
- Medical University of South Carolina (US)
- Corresponding author
- Toole, Bryan P.
- ORCID
- Toole, Bryan P.
- Venue
- Nature Reviews Cancer
- Published
- 2004-07
- Volume
- 4
- Issue
- 7
- Pages
- 528-539
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2089753996
- Semantic Scholar
- 3488563c03cedbae83c9c1d8423aeb0c6b33a4a3
- Cited by
- 2,125
- References
- 188
- Citations by year
- 2026: 61 · 2025: 78 · 2024: 81 · 2023: 97 · 2022: 93 · 2021: 129 · 2020: 120 · 2019: 120 · 2018: 116 · 2017: 112 · 2016: 150 · 2015: 130 · 2014: 126 · 2013: 103 · 2012: 99
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- hyaluronic acid, extracellular matrix, cell microenvironment, tumor microenvironment, embryonic development, wound healing, inflammation, carcinogenesis, cancer therapy
- MeSH terms
- Adult, Animals, Cell Survival, Connective Tissue, Extracellular Matrix, Embryonic and Fetal Development, Forecasting, Humans, Hyaluronic Acid, Hyaluronoglucosaminidase, Inflammation, Joints, Neoplasm Invasiveness, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Ultrasonography, Wound Healing, Signal Transduction, Drug Resistance, Multiple, Hyaluronan Receptors, Drug Resistance, Neoplasm, Xenograft Model Antitumor Assays
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