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Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons
Open accessAbstract
We have cloned and expressed a novel proton-gated Na+ channel subunit that is specific for sensory neurons. In COS cells, it forms a Na+ channel that responds to a drop of the extracellular pH with both a rapidly inactivating and a sustained Na+ current. This biphasic kinetic closely resembles that of the H+-gated current described in sensory neurons of dorsal root ganglia (1). Both the abundance of this novel H+-gated Na+ channel subunit in sensory neurons and the kinetics of the channel suggest that it is part of the channel complex responsible for the sustained H+-activated cation current in sensory neurons that is thought to be important for the prolonged perception of pain that accompanies tissue acidosis (1, 2).
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Cited by
Impaired nociception and pain sensation in mice lacking the capsaicin receptor
Caterina, M. J., Leffler, A., Malmberg, A. B., Martin, W. J., Trafton, J., Petersen-Zeitz, K. R., Koltzenburg, M., Basbaum, A. I., & Julius, D. (2000) · Science · doi:10.1126/science.288.5464.306 · Cited by 3,544
The induction of pain: an integrative review
Millan, M. J. (1999) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00048-3 · Cited by 1,774
The ASICs: Signaling molecules? Modulators?
Krishtal, O. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00210-8 · Cited by 418
Ugawa, S., Ueda, T., Ishida, Y., Nishigaki, M., Shibata, Y., & Shimada, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15709 · Cited by 296
Qiu, F., Qiu, C., Cai, H., Liu, T., Qu, Z., Yang, Z., Li, J., Zhou, Q., & Hu, W. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12635 · Cited by 67
Metadata
- Authors
- Waldmann, R., Bassilana, F., de Weille, J., Champigny, G., Heurteaux, C., & Lazdunski, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 272
- Issue
- 34
- Pages
- 20975-20978
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2009199141
- Cited by
- 534
- References
- 0
- FWCI
- 7.09
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Waldmann, R., Bassilana, F., de Weille, J., Champigny, G., Heurteaux, C., & Lazdunski, M. (1997). Molecular Cloning of a Non-inactivating Proton-gated Na+ Channel Specific for Sensory Neurons. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.34.20975
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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