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Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli
Open accessAbstract
High levels of guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), generated in response to amino acid starvation in Escherichia coli, lead to massive accumulations of inorganic polyphosphate (polyP). Inasmuch as the activities of the principal enzymes that synthesize and degrade polyP fluctuate only slightly, the polyP accumulation can be attributed to a singular and profound inhibition by pppGpp and/or ppGpp of the hydrolytic breakdown of polyP by exopolyphosphatase, thereby blocking the dynamic turnover of polyP. The Ki values of 10 microM for pppGpp and 200 microM for ppGpp are far below the concentrations of these nucleotides in nutritionally stressed cells. In the complex metabolic network of pppGpp and ppGpp, the greater inhibitory effect of pppGpp (compared with ppGpp) leading to the accumulation of polyP, may have some significance in the relative roles played by these regulatory compounds.
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Citations
Cited by
Hengge-Aronis, R. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.3.373-395.2002 · Cited by 936
Stress-Induced Mutagenesis in Bacteria
Foster, P. L. (2007) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230701648494 · Cited by 536
Maisonneuve, E., Castro-Camargo, M., & Gerdes, K. (2013) · Cell · doi:10.1016/j.cell.2013.07.048 · Cited by 438
RetractedBacterial Growth and Cell Division: a Mycobacterial Perspective
Hett, E. C., & Rubin, E. J. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00028-07 · Cited by 408
Revisiting the stringent response, ppGpp and starvation signaling
Chatterji, D., & Kumar Ojha, A. (2001) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(00)00182-x · Cited by 364
Metadata
- Authors
- Kuroda, A., Murphy, H., Cashel, M., & Kornberg, A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-08
- Volume
- 272
- Issue
- 34
- Pages
- 21240-21243
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2087345689
- Cited by
- 250
- References
- 0
- FWCI
- 4.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli. https://app.cochat.ai/papers/10.1074/jbc.272.34.21240
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- Kuroda, A., Murphy, H., Cashel, M., & Kornberg, A. (1997). Guanosine Tetra- and Pentaphosphate Promote Accumulation of Inorganic Polyphosphate in Escherichia coli. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.34.21240
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