Stress-Induced Mutagenesis in Bacteria
Open accessAbstract
Bacteria spend their lives buffeted by changing environmental conditions. To adapt to and survive these stresses, bacteria have global response systems that result in sweeping changes in gene expression and cellular metabolism. These responses are controlled by master regulators, which include: alternative sigma factors, such as RpoS and RpoH; small molecule effectors, such as ppGpp; gene repressors such as LexA; and, inorganic molecules, such as polyphosphate. The response pathways extensively overlap and are induced to various extents by the same environmental stresses. These stresses include nutritional deprivation, DNA damage, temperature shift, and exposure to antibiotics. All of these global stress responses include functions that can increase genetic variability. In particular, up-regulation and activation of error-prone DNA polymerases, down-regulation of error-correcting enzymes, and movement of mobile genetic elements are common features of several stress responses. The result is that under a variety of stressful conditions, bacteria are induced for genetic change. This transient mutator state may be important for adaptive evolution.
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Because the mutation rate is constant, smaller number of cells in a given culture will result in smaller average number of mutations, which in turn will increase the fraction of smaller colony counts.
“In essence, because the mutation rate is constant, smaller number of cells in a given culture will result in smaller average number of mutations (see (2)), which in turn will increase the fraction of smaller colony counts.”
From Efficient, robust, and versatile fluctuation data analysis using MLE MUtation Rate calculator (mlemur) (2023) · cites this paper as [2]
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“Indeed, several studies have shown that mutations do not usually accumulate when cells are incubated without any nutrients at all (Cairns et al., 1988; Cairns et al., 1991; Foster, 1997; Hughes et al., 1997) (although this is not true of movement of IS elements; see below).”
BackgroundMethodInfluentialLong-term survival during stationary phase: evolution and the GASP phenotype
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The SOS response regulates adaptive mutation
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Waters, L. S., Minesinger, B. K., Wiltrout, M. E., D'Souza, S., Woodruff, R. V., & Walker, G. C. (2009) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00034-08 · Cited by 591 · see citing works
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Russo, M., Crisafulli, G., Sogari, A., Reilly, N. M., Arena, S., Lamba, S., Bartolini, A., Amodio, V., Magrì, A., Novara, L., et al. (2019) · Science · doi:10.1126/science.aav4474 · Cited by 433 · see citing works
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Sun, H., Luan, G., Ma, Y., Lou, W., Chen, R., Feng, D., Zhang, S., Sun, J., & Lu, X. (2023) · Nature Communications · doi:10.1038/s41467-023-36964-5 · Cited by 56 · see citing works
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- Authors
- Foster, P. L.
- Affiliations
- Indiana University Bloomington (US)
- Corresponding author
- Foster, Patricia L.
- ORCID
- Foster, Patricia L.
- Venue
- Critical Reviews in Biochemistry and Molecular Biology
- Publisher
- Informa UK Limited
- Published
- 2007-01
- Volume
- 42
- Issue
- 5
- Pages
- 373-397
- ISSN
- 0045-6411 (ISSN-L)
- 1040-9238
- 1549-7798
- PMC
- PMC2747772
- OpenAlex
- W2135721494
- Cited by
- 536
- References
- 4
- Citations by year
- 2026: 21 · 2025: 30 · 2024: 33 · 2023: 32 · 2022: 24 · 2021: 29 · 2020: 33 · 2019: 42 · 2018: 24 · 2017: 27 · 2016: 27 · 2015: 27 · 2014: 27 · 2013: 29 · 2012: 30
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Critical Reviews in Biochemistry and Molecular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM065175, GM065175)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- stress-induced mutagenesis, bacterial stress response, global gene regulation, alternative sigma factor, RpoS, rpoH, ppGpp, LexA, polyphosphate, nutritional deficiency, DNA damage, temperature change, antibiotic stress, error-prone DNA polymerases, mobile genetic elements, adaptive evolution, genetic variation
- MeSH terms
- Adaptation, Physiological, Bacterial Proteins, DNA Damage, Escherichia coli, Models, Biological, Mutation, Polyphosphates, SOS Response, Genetics, Gene Expression Regulation, Bacterial, Mutagenesis, Oxidative Stress, Heat-Shock Response
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