The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation
Open accessAbstract
The nuclear factor NF-kappaB is a pleiotropic transcription factor whose activation results in inflammation, viral replication, and growth modulation. Due to its role in pathogenesis, NF-kappaB is considered a key target for drug development. In the present report we show that sanguinarine (a benzophenanthridine alkaloid), a known anti-inflammatory agent, is a potent inhibitor of NF-kappaB activation. Treatment of human myeloid ML-1a cells with tumor necrosis factor rapidly activated NF-kappaB, this activation was completely suppressed by sanguinarine in a dose- and time-dependent manner. Sanguinarine did not inhibit the binding of NF-kappaB protein to the DNA but rather inhibited the pathway leading to NF-kappaB activation. The reversal of inhibitory effects of sanguinarine by reducing agents suggests a critical sulfhydryl group is involved in NF-kappaB activation. Sanguinarine blocked the tumor necrosis factor-induced phosphorylation and degradation of IkappaBalpha, an inhibitory subunit of NF-kappaB, and inhibited translocation of p65 subunit to the nucleus. As sanguinarine also inhibited NF-kappaB activation induced by interleukin-1, phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers. Overall, our results demonstrate that sanguinarine is a potent suppressor of NF-kappaB activation and it acts at a step prior to IkappaBalpha phosphorylation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 4,979
Function and Activation of NF-kappaB in the Immune System
Baeuerle, P. A., & Henkel, T. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001041 · Cited by 4,745
Schreiber, E., Matthias, P., Müller, M. M., & Schaffner, W. (1989) · Nucleic Acids Research · doi:10.1093/nar/17.15.6419 · Cited by 4,179
Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science · doi:10.1126/science.270.5234.286 · Cited by 2,390
Structure, Regulation and Function of NF-kappaB
Siebenlist, U., Franzoso, G., & Brown, K. (1994) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.10.110194.002201 · Cited by 2,075
Inhibition of NF-κB by Sodium Salicylate and Aspirin
Kopp, E., & Ghosh, S. (1994) · Science · doi:10.1126/science.8052854 · Cited by 1,753
Role of Transcriptional Activation of IκBα in Mediation of Immunosuppression by Glucocorticoids
Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., & Baldwin, A. S. (1995) · Science · doi:10.1126/science.270.5234.283 · Cited by 1,699
Chen, Z., Hagler, J., Palombella, V. J., Melandri, F., Scherer, D., Ballard, D., & Maniatis, T. (1995) · Genes & Development · doi:10.1101/gad.9.13.1586 · Cited by 1,290
Chelerythrine is a potent and specific inhibitor of protein kinase C
Herbert, J. M., Augereau, J. M., Gleye, J., & Maffrand, J. P. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)91544-3 · Cited by 1,195
Natarajan, K., Singh, S., Burke, T. R., Grunberger, D., & Aggarwal, B. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9090 · Cited by 1,139
Self-citation
Cited by
Nuclear transcription factor-κB as a target for cancer drug development
Garg, A., & Aggarwal, B. (2002) · Leukemia · doi:10.1038/sj.leu.2402482 · Cited by 441
Self-citationAlkaloids Isolated from Natural Herbs as the Anticancer Agents
Lu, J.-J., Bao, J.-L., Chen, X.-P., Huang, M., & Wang, Y.-T. (2012) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2012/485042 · Cited by 384
Ruiz-Ortega, M., Lorenzo, O., Rupérez, M., König, S., Wittig, B., & Egido, J. (2000) · Circulation Research · doi:10.1161/01.res.86.12.1266 · Cited by 331
Estrov, Z., Shishodia, S., Faderl, S., Harris, D., Van, Q., Kantarjian, H. M., Talpaz, M., & Aggarwal, B. B. (2003) · Blood · doi:10.1182/blood-2002-11-3550 · Cited by 306
Self-citationChainy, G. B., Manna, S. K., Chaturvedi, M. M., & Aggarwal, B. B. (2000) · Oncogene · doi:10.1038/sj.onc.1203614 · Cited by 215
Self-citation
Metadata
- Authors
- Chaturvedi, M. M., Kumar, A., Darnay, B. G., Chainy, G. B. N., Agarwal, S., & Aggarwal, B. B.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1997-11
- Volume
- 272
- Issue
- 48
- Pages
- 30129-30134
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2081302041
- Cited by
- 286
- References
- 29
- FWCI
- 3.61
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation. https://app.cochat.ai/papers/10.1074/jbc.272.48.30129
- The paper
- Chaturvedi, M. M., Kumar, A., Darnay, B. G., Chainy, G. B. N., Agarwal, S., & Aggarwal, B. B. (1997). Sanguinarine (Pseudochelerythrine) Is a Potent Inhibitor of NF-κB Activation, IκBα Phosphorylation, and Degradation. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.272.48.30129
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
