The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.
Alkaloids Isolated from Natural Herbs as the Anticancer Agents
Open accessAbstract
Alkaloids are important chemical compounds that serve as a rich reservoir for drug discovery. Several alkaloids isolated from natural herbs exhibit antiproliferation and antimetastasis effects on various types of cancers both in vitro and in vivo. Alkaloids, such as camptothecin and vinblastine, have already been successfully developed into anticancer drugs. This paper focuses on the naturally derived alkaloids with prospective anticancer properties, such as berberine, evodiamine, matrine, piperine, sanguinarine, and tetrandrine, and summarizes the mechanisms of action of these compounds. Based on the information in the literature that is summarized in this paper, the use of alkaloids as anticancer agents is very promising, but more research and clinical trials are necessary before final recommendations on specific alkaloids can be made.
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Cites
1 retracted
Singh, T., Vaid, M., Katiyar, N., Sharma, S., & Katiyar, S. K. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq215 · Cited by 136
RetractedBlack Pepper and its Pungent Principle-Piperine: A Review of Diverse Physiological Effects
Srinivasan, K. (2007) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408390601062054 · Cited by 821
Targeting breast stem cells with the cancer preventive compounds curcumin and piperine
Kakarala, M., Brenner, D. E., Korkaya, H., Cheng, C., Tazi, K., Ginestier, C., Liu, S., Dontu, G., & Wicha, M. S. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-009-0612-x · Cited by 503
Tang, J., Feng, Y., Tsao, S., Wang, N., Curtain, R., & Wang, Y. (2009) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2009.08.009 · Cited by 491
Self-citationPiperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4
Bhardwaj, R. K., Glaeser, H., Becquemont, L., Klotz, U., Gupta, S. K., & Fromm, M. F. (2002) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.034728 · Cited by 444
A systematic review of the anticancer properties of berberine, a natural product from Chinese herbs
Sun, Y., Xun, K., Wang, Y., & Chen, X. (2009) · Anti-Cancer Drugs · doi:10.1097/cad.0b013e328330d95b · Cited by 417
Self-citationAnti-cancer natural products isolated from chinese medicinal herbs
Tan, W., Lu, J., Huang, M., Li, Y., Chen, M., Wu, G., Gong, J., Zhong, Z., Xu, Z., Dang, Y., et al. (2011) · Chinese Medicine · doi:10.1186/1749-8546-6-27 · Cited by 396
Self-citationBerberine: a plant alkaloid with therapeutic potential for central nervous system disorders
Kulkarni, S. K., & Dhir, A. (2010) · Phytotherapy Research · doi:10.1002/ptr.2968 · Cited by 367
Mantena, S. K., Sharma, S. D., & Katiyar, S. K. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-05-0448 · Cited by 353
Yu, H.-H., Kim, K.-J., Cha, J.-D., Kim, H.-K., Lee, Y.-E., Choi, N.-Y., & You, Y.-O. (2005) · Journal of Medicinal Food · doi:10.1089/jmf.2005.8.454 · Cited by 311
Cited by
Dhyani, P., Quispe, C., Sharma, E., Bahukhandi, A., Sati, P., Attri, D. C., Szopa, A., Sharifi-Rad, J., Docea, A. O., Mardare, I., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02624-9 · Cited by 483
Aung, T., Qu, Z., Kortschak, R., & Adelson, D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18030656 · Cited by 319
An Overview of Potential Natural Photosensitizers in Cancer Photodynamic Therapy
Aziz, B., Aziz, I., Khurshid, A., Raoufi, E., Esfahani, F. N., Jalilian, Z., Mozafari, M. R., Taghavi, E., & Ikram, M. (2023) · Biomedicines · doi:10.3390/biomedicines11010224 · Cited by 70
“They are also beneficial as supplements, diet ingredients, pharmaceuticals (such as camptothecin and vinblastine, which are used as chemo drugs [76]), and in other applications in human life [77–82].”
Background
Metadata
- Authors
- Lu, J.-J., Bao, J.-L., Chen, X.-P., Huang, M., & Wang, Y.-T.
- Venue
- Evidence-Based Complementary and Alternative Medicine
- Publisher
- Wiley
- Published
- 2012
- Volume
- 2012
- Pages
- 1-12
- ISSN
- 1741-427X (ISSN-L)
- 1741-4288
- OpenAlex
- W2132316821
- Cited by
- 384
- References
- 117
- FWCI
- 9.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Lu, J.-J., Bao, J.-L., Chen, X.-P., Huang, M., & Wang, Y.-T. (2012). Alkaloids Isolated from Natural Herbs as the Anticancer Agents. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2012/485042
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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