The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
X-ray Crystal Structure of the Human Galectin-3 Carbohydrate Recognition Domain at 2.1-Å Resolution
Open accessAbstract
Galectins are a family of lectins which share similar carbohydrate recognition domains (CRDs) and affinity for small beta-galactosides, but which show significant differences in binding specificity for more complex glycoconjugates. We report here the x-ray crystal structure of the human galectin-3 CRD, in complex with lactose and N-acetyllactosamine, at 2.1-A resolution. This structure represents the first example of a CRD determined from a galectin which does not show the canonical 2-fold symmetric dimer organization. Comparison with the published structures of galectins-1 and -2 provides an explanation for the differences in carbohydrate-binding specificity shown by galectin-3, and for the fact that it fails to form dimers by analogous CRD-CRD interactions.
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Cites
PROCHECK: a program to check the stereochemical quality of protein structures
Laskowski, R. A., MacArthur, M. W., Moss, D. S., & Thornton, J. M. (1993) · Journal of Applied Crystallography · doi:10.1107/s0021889892009944 · Cited by 24,581
Galectins: A family of animal β-galactoside-binding lectins
Barondes, S. H., Castronovo, V., Cooper, D. N. W., Cummings, R. D., Drickamer, K., Felzi, T., Gitt, M. A., Hirabayashi, J., Hughes, C., Kasai, K.-I., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90498-7 · Cited by 1,223
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Cited by
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Li, F. (2016) · Annual Review of Virology · doi:10.1146/annurev-virology-110615-042301 · Cited by 2,740
Galectinomics: finding themes in complexity
Cooper, D. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00310-0 · Cited by 585
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Cecioni, S., Imberty, A., & Vidal, S. (2015) · Chemical Reviews · doi:10.1021/cr500303t · Cited by 544
Ahmad, N., Gabius, H.-J., André, S., Kaltner, H., Sabesan, S., Roy, R., Liu, B., Macaluso, F., & Brewer, C. F. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312834200 · Cited by 517
Metadata
- Authors
- Seetharaman, J., Kanigsberg, A., Slaaby, R., Leffler, H., Barondes, S. H., & Rini, J. M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 273
- Issue
- 21
- Pages
- 13047-13052
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2009388678
- Cited by
- 430
- References
- 2
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Seetharaman, J., Kanigsberg, A., Slaaby, R., Leffler, H., Barondes, S. H., & Rini, J. M. (1998). X-ray Crystal Structure of the Human Galectin-3 Carbohydrate Recognition Domain at 2.1-Å Resolution. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.21.13047
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