The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Rrp6p, the Yeast Homologue of the Human PM-Scl 100-kDa Autoantigen, Is Essential for Efficient 5.8 S rRNA 3′ End Formation
Open accessAbstract
The eukaryotic 25 S, 18 S, and 5.8 S rRNAs are synthesized as a single transcript with two internal transcribed spacers (ITS1 and ITS2), which are removed by endo- and exoribonucleolytic steps to produce mature rRNA. Genetic selection for suppressors of a polyadenylation defect yielded two cold-sensitive alleles of a gene that we named RRP6 (ribosomal RNA processing). Molecular cloning of RRP6 revealed its homology to a 100-kDa human, nucleolar PM-Scl autoantigen and to Escherichia coli RNase D, a 3'-5' exoribonuclease. Recessive mutations in rrp6 result in the accumulation of a novel 5. 8 S rRNA processing intermediate, called 5.8 S*, which has normal 5' ends, but retains approximately 30 nucleotides of ITS2. Pulse-chase analysis of 5.8 S rRNA processing in an rrp6- strain revealed a precursor-product relationship between 5.8 S* and 5.8 S rRNAs, suggesting that Rrp6p plays a role in the removal of the last 30 nucleotides of ITS2 from 5.8 S precursors. A portion of 5.8 S* rRNA assembles into 60 S ribosomes which form polyribosomes, suggesting that they function in protein synthesis. These findings indicate that Rrp6p plays a role in 5.8 S rRNA 3' end formation, and they identify a functional intermediate in the rRNA processing pathway.
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van Hoof, A., Lennertz, P., & Parker, R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.2.441-452.2000 · Cited by 359
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Extensive Degradation of RNA Precursors by the Exosome in Wild-Type Cells
Gudipati, R. K., Xu, Z., Lebreton, A., Séraphin, B., Steinmetz, L. M., Jacquier, A., & Libri, D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.018 · Cited by 236
Transcriptome-wide Analysis of Exosome Targets
Schneider, C., Kudla, G., Wlotzka, W., Tuck, A., & Tollervey, D. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.013 · Cited by 195
Metadata
- Authors
- Briggs, M. W., Burkard, K. T. D., & Butler, J. S.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-05
- Volume
- 273
- Issue
- 21
- Pages
- 13255-13263
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2028513775
- Cited by
- 310
- References
- 37
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Rrp6p, the Yeast Homologue of the Human PM-Scl 100-kDa Autoantigen, Is Essential for Efficient 5.8 S rRNA 3′ End Formation. https://app.cochat.ai/papers/10.1074/jbc.273.21.13255
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- Briggs, M. W., Burkard, K. T. D., & Butler, J. S. (1998). Rrp6p, the Yeast Homologue of the Human PM-Scl 100-kDa Autoantigen, Is Essential for Efficient 5.8 S rRNA 3′ End Formation. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.21.13255
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