Cited by 173Heat shock proteins researchMitochondrial Function and PathologyNeurological diseases and metabolism

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Mt-Hsp70 Homolog, Ssc2p, Required for Maturation of Yeast Frataxin and Mitochondrial Iron Homeostasis

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Knight, Simon A.B., Sepuri, Naresh Babu V., Pain, Debkumar, Dancis, Andrew·1998·Journal of Biological Chemistry

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Abstract

Here we show that the yeast mitochondrial chaperone Ssc2p, a homolog of mt-Hsp70, plays a critical role in mitochondrial iron homeostasis. Yeast with ssc2-1 mutations were identified by a screen for altered iron-dependent gene regulation and mitochondrial dysfunction. These mutants exhibit increased cellular iron uptake, and the iron accumulates exclusively within mitochondria. Yfh1p is homologous to frataxin, the human protein implicated in the neurodegenerative disease, Friedreich's ataxia. Like mutants of yfh1, ssc2-1 mutants accumulate vast quantities of iron in mitochondria. Furthermore, using import studies with isolated mitochondria, we demonstrate a specific role for Ssc2p in the maturation of Yfh1p within this organelle. This function for a mitochondrial Hsp70 chaperone is likely to be conserved, implying that a human homolog of Ssc2p may be involved in iron homeostasis and in neurodegenerative disease.

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Authors: Knight, S. A. B., Sepuri, N. B. V., Pain, D., & Dancis, A.
Affiliations: University of Pennsylvania (US)
Corresponding author: Dancis, Andrew
ORCID: Knight, Simon A.B.
Sepuri, Naresh Babu V.
Dancis, Andrew
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-07
Volume: 273
Issue: 29
Pages: 18389-18393
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.29.18389
OpenAlex: W1976493565
Cited by: 173
References: 26
Citations by year: 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 3 · 2017: 7 · 2016: 2 · 2015: 5 · 2014: 6 · 2013: 2 · 2012: 8
FWCI: 6.17
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8147 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Funders: American Heart Association
W. W. Smith Charitable Trust
University of Pennsylvania
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords: mitochondrial Hsp70, frataxin, mitochondrial iron homeostasis, protein maturation, mitochondrial chaperone, Friedreich's ataxia, iron accumulation, iron absorption, mitochondrial dysfunction, Saccharomyces cerevisiae
MeSH terms: Frataxin, Fungal Proteins, Homeostasis, Iron, Mitochondria, Models, Biological, Saccharomyces cerevisiae, Gene Library, Mutagenesis, Site-Directed, Phosphotransferases (Alcohol Group Acceptor), Molecular Chaperones, HSP70 Heat-Shock Proteins, Mitochondrial Proteins, Saccharomyces cerevisiae Proteins, Iron-Binding Proteins

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Mt-Hsp70 Homolog, Ssc2p, Required for Maturation of Yeast Frataxin and Mitochondrial Iron Homeostasis

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