Requirement for Hsp90 and a CyP-40-type Cyclophilin in Negative Regulation of the Heat Shock Response
Open accessAbstract
The heat shock response is a highly conserved mechanism that allows cells to withstand a variety of stress conditions. Activation of this response is characterized by increased synthesis of heat shock proteins (HSPs), which protect cellular proteins from stress-induced denaturation. Heat shock transcription factors (HSFs) are required for increased expression of HSPs during stress conditions and can be found in complexes containing components of the Hsp90 molecular chaperone machinery, raising the possibility that Hsp90 is involved in regulation of the heat shock response. To test this, we have assessed the effects of mutations that impair activity of the Hsp90 machinery on heat shock related events in Saccharomyces cerevisiae. Mutations that either reduce the level of Hsp90 protein or eliminate Cpr7, a CyP-40-type cyclophilin required for full Hsp90 function, resulted in increased HSF-dependent activities. Genetic tests also revealed that Hsp90 and Cpr7 function synergistically to repress gene expression from HSF-dependent promoters. Conditional loss of Hsp90 activity resulted in both increased HSF-dependent gene expression and acquisition of a thermotolerant phenotype. Our results reveal that Hsp90 and Cpr7 are required for negative regulation of the heat shock response under both stress and nonstress conditions and establish a specific endogenous role for the Hsp90 machinery in S. cerevisiae.
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Hsp90 activity is tightly controlled via post-translational regulation and an autoregulatory loop involving Hsf1.
“Furthermore, although Hsp90 levels increase following environmental challenges, Hsp90 activity is tightly controlled via post-translational regulation and an autoregulatory loop involving the heat shock transcription factor, Hsf1.”
From Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs (2012) · cites this paper as [59]
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- Authors
- Duina, A. A., Kalton, H. M., & Gaber, R. F.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Gaber, Richard F.
- ORCID
- Duina, Andrea A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-07
- Volume
- 273
- Issue
- 30
- Pages
- 18974-18978
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1979344081
- Cited by
- 143
- References
- 39
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 5 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 3 · 2014: 4 · 2013: 8 · 2012: 13
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- HSP90, heat shock response, heat shock transcription factor, negative regulation of gene expression, heat tolerance, Saccharomyces cerevisiae
- MeSH terms
- Heat Shock Transcription Factors, Peptidyl-Prolyl Isomerase F, Peptidyl-Prolyl Isomerase D, beta-Galactosidase, Carrier Proteins, DNA-Binding Proteins, Saccharomyces cerevisiae, Transcription Factors, Gene Expression, Mutagenesis, Site-Directed, HSP90 Heat-Shock Proteins, Heat-Shock Response, Peptidylprolyl Isomerase, Cyclophilins
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