Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum

Dorner, Cornelia; Ciossek, Thomas; Müller, Susanne; Møller, Niels Peter H.; Ullrich, Axel; Lammers, Reiner

doi:10.1074/jbc.273.32.20267

Cited by 136Cellular transport and secretionMicrotubule and mitosis dynamicsNuclear Structure and Function

Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum

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Dorner, Cornelia, Ciossek, Thomas, Müller, Susanne, Møller, Niels Peter H., Ullrich, Axel, Lammers, Reiner·1998·Journal of Biological Chemistry

DOI 10.1074/jbc.273.32.20267

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Abstract

Kinesins comprise a large family of microtubule-based motor proteins, of which individual members mediate specific types of motile processes. Using the ezrin domain of the protein-tyrosine phosphatase PTPD1 as a bait in a yeast two-hybrid screen, we identified a new kinesin-like protein, KIF1C. KIF1C represents a member of the Unc104 subfamily of kinesin-like proteins that are involved in the transport of mitochondria or synaptic vesicles in axons. Like its homologues, the 1103-amino acid protein KIF1C consists of an amino-terminal motor domain followed by a U104 domain and probably binds to target membranes through carboxyl-terminal sequences. Interestingly, KIF1C was tyrosine-phosphorylated after peroxovanadate stimulation when overexpressed in 293 or NIH3T3 fibroblasts or in native C2C12 cells. Using immunofluorescence, we found that KIF1C is localized primarily at the Golgi apparatus. In brefeldin A-treated cells, the Golgi membranes and KIF1C redistributed to the endoplasmic reticulum (ER). This brefeldin A-induced flow of Golgi membranes into the ER was inhibited in cells transiently overexpressing catalytically inactive KIF1C. In conclusion, our data suggest an involvement of tyrosine phosphorylation in the regulation of the Golgi to ER membrane flow and describe a new kinesin-like motor protein responsible for this transport.

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KIF1C K103A should not bind ATP.
“KIF1C K103A, that should not bind ATP (Dorner et al., 1998; Li et al., 1998)”
From The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization (2015) · cites this paper as Dorner et al., 1998

Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
Molecular cloning: A laboratory manual
Deininger, P. L. (1990) · Analytical Biochemistry · doi:10.1016/0003-2697(90)90595-z · Cited by 84,684 · see citing works
High-Efficiency Transformation of Mammalian Cells by Plasmid DNA
Chen, C., & Okayama, H. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.8.2745 · Cited by 5,374 · see citing works
[19] Rapid and efficient site-specific mutagenesis without phenotypic selection
Kunkel, T. A., Roberts, J. D., & Zakour, R. A. (1987) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(87)54085-x · Cited by 5,341 · see citing works
Production of high-titer helper-free retroviruses by transient transfection.
Pear, W. S., Nolan, G. P., Scott, M. L., & Baltimore, D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8392 · Cited by 2,267 · see citing works
The P-loop — a common motif in ATP- and GTP-binding proteins
Saraste, M., Sibbald, P. R., & Wittinghofer, A. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90281-f · Cited by 2,099 · see citing works
Mammalian Ras interacts directly with the serine/threonine kinase Raf.
Vojtek, A., Hollenberg, S., & Cooper, J. A. (1993) · Cell · doi:10.1016/0092-8674(93)90307-c · Cited by 1,971 · see citing works
Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: Evidence for membrane cycling from Golgi to ER
Lippincott‐Schwartz, J., Yuan, L. C., Bonifacino, J. S., & Klausner, R. D. (1989) · Cell · doi:10.1016/0092-8674(89)90685-5 · Cited by 1,688 · see citing works
ER-to-Golgi transport visualized in living cells
Presley, J. F., Cole, N. B., Schroer, T. A., Hirschberg, K., Zaal, K. J. M., & Lippincott‐Schwartz, J. (1997) · Nature · doi:10.1038/38001 · Cited by 1,173 · see citing works
Microtubule-dependent retrograde transport of proteins into the ER in the presence of brefeldin a suggests an ER recycling pathway
Lippincott‐Schwartz, J., Donaldson, J. G., Schweizer, A., Berger, E. G., Hauri, H.-P., Yuan, L. C., & Klausner, R. D. (1990) · Cell · doi:10.1016/0092-8674(90)90096-w · Cited by 967 · see citing works
Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.
Fujiwara, T., Oda, K., Yokota, S., Takatsuki, A., & Ikehara, Y. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)81393-5 · Cited by 887 · see citing works
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons.
Tsukita, S., Oishi, K., Sato, N., Sagara, J., Kawai, A., & Tsukita, S. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.126.2.391 · Cited by 779 · see citing works
The neuron-specific kinesin superfamily protein KIF1A is a uniqye monomeric motor for anterograde axonal transport of synaptic vesicle precursors
Okada, Y., Yamazaki, H., Sekine‐Aizawa, Y., & Hirokawa, N. (1995) · Cell · doi:10.1016/0092-8674(95)90538-3 · Cited by 679 · see citing works
The two-hybrid system: an assay for protein-protein interactions
Fields, S., & Sternglanz, R. (1994) · Trends in Genetics · doi:10.1016/0168-9525(90)90012-u · Cited by 646 · see citing works
Identification of a New Family of Tissue-Specific Basic Helix-Loop-Helix Proteins with a Two-Hybrid System
Hollenberg, S. M., Sternglanz, R., Cheng, P. F., & Weintraub, H. M. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.7.3813 · Cited by 643 · see citing works
KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria
Nangaku, M., Sato-Yoshitake, R., Okada, Y., Noda, Y., Takemura, R., Yamazaki, H., & Hirokawa, N. (1994) · Cell · doi:10.1016/0092-8674(94)90012-4 · Cited by 598 · see citing works
[30] Prediction and analysis of coiled-coil structures
Lupas, A. N. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)66032-7 · Cited by 575 · see citing works
Kinesin-related gene unc-104 is required for axonal transport of synaptic vesicles in C. elegans
Hall, D. H., & Hedgecock, E. M. (1991) · Cell · doi:10.1016/0092-8674(91)90391-b · Cited by 564 · see citing works
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.
Posner, B. I., Faure, R. L., Burgess, J. W., Bevan, A. P., Lachance, D., Zhang-Sun, G., Fantus, I. G., Ng, J. B., Hall, D. A., & Lum, B. S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41818-7 · Cited by 532 · see citing works
Localization of cytoplasmic dynein to mitotic spindles and kinetochores
Steuer, E. R., Wordeman, L. G., Schroer, T. A., & Sheetz, M. P. (1990) · Nature · doi:10.1038/345266a0 · Cited by 503 · see citing works
Point mutation at the ATP binding site of EGF receptor abolishes protein-tyrosine kinase activity and alters cellular routing
Honegger, A. (1987) · Cell · doi:10.1016/0092-8674(87)90147-4 · Cited by 491 · see citing works
Dissociation of a 110-kD peripheral membrane protein from the Golgi apparatus is an early event in brefeldin A action.
Donaldson, J. G., Lippincott‐Schwartz, J., Bloom, G. S., et al. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.111.6.2295 · Cited by 384 · see citing works
Crystal structure of the motor domain of the kinesin-related motor ncd
Sablin, E. P., Kull, F. J., Cooke, R., Vale, R. D., & Fletterick, R. J. (1996) · Nature · doi:10.1038/380555a0 · Cited by 353 · see citing works
Kinesin family in murine central nervous system.
Aizawa, H., Sekine, Y., Takemura, R., Zhang, Z., Nangaku, M., & Hirokawa, N. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.5.1287 · Cited by 321 · see citing works
Associations of elements of the Golgi apparatus with microtubules.
Rogalski, A. A., & Singer, S. J. (1984) · The Journal of Cell Biology · doi:10.1083/jcb.99.3.1092 · Cited by 293 · see citing works
Switches, latches, and amplifiers: common themes of G proteins and molecular motors.
Vale, R. D. (1996) · The Journal of Cell Biology · doi:10.1083/jcb.135.2.291 · Cited by 258 · see citing works
Kinesin is the motor for microtubule-mediated Golgi-to-ER membrane traffic [published errata appear in J Cell Biol 1995 Mar;128(5):following 988 and 1995 May;129(3):893]
Lippincott‐Schwartz, J. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.128.3.293 · Cited by 237 · see citing works
Point mutation of adenosine triphosphate-binding motif generated rigor kinesin that selectively blocks anterograde lysosome membrane transport.
Nakata, T., & Hirokawa, N. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.131.4.1039 · Cited by 235 · see citing works
The C. elegans unc-104 4 gene encodes a putative kinesin heavy chain-like protein
Otsuka, A. J., Jeyaprakash, A., Garcı́a-Añoveros, J., Tang, L., Fisk, G. J., Hartshorne, T. A., Franco, R., & Bornt, T. (1991) · Neuron · doi:10.1016/0896-6273(91)90126-k · Cited by 217 · see citing works
Kinectin, a major kinesin-binding protein on ER.
Toyoshima, I., Yu, H., Steuer, E. R., & Sheetz, M. P. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.5.1121 · Cited by 217 · see citing works
A Novel 58-kDa Protein Associates with the Golgi Apparatus and Microtubules
Bloom, G. S., & Brashear, T. A. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)71590-1 · Cited by 214 · see citing works
Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin.
Yang, Q., & Tonks, N. K. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.14.5949 · Cited by 205 · see citing works
Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B.
Yamazaki, H., Nakata, T., Okada, Y., & Hirokawa, N. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8443 · Cited by 197 · see citing works
Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
Gu, M., York, J. D., Warshawsky, I., & Majerus, P. W. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5867 · Cited by 193 · see citing works
Differential phosphorylation in vivo of cytoplasmic dynein associated with anterogradely moving organelles.
Dillman, J. F., & Pfister, K. K. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.6.1671 · Cited by 177 · see citing works
Kinesin proteins: A phylum of motors for microtubule‐based motility
Moore, J. D., & Endow, S. A. (1996) · BioEssays · doi:10.1002/bies.950180308 · Cited by 168 · see citing works
The phosphorylation of kinesin regulates its binding to synaptic vesicles.
Sato-Yoshitake, R., Yorifuji, H., Inagaki, M., & Hirokawa, N. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)35926-x · Cited by 160 · see citing works
Differential activities of protein tyrosine phosphatases in intact cells.
Lammers, R., Bossenmaier, B., Cool, D. E., et al. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41551-7 · Cited by 159 · see citing works
Self-citation
Sorting and retrieval between the endoplasmic reticulum and Golgi apparatus
Pelham, H. R. B. (1995) · Current Opinion in Cell Biology · doi:10.1016/0955-0674(95)80010-7 · Cited by 157 · see citing works
Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome
Nakagawa, T., Tanaka, Y., Matsuoka, E., Kondo, S., Okada, Y., Noda, Y., Kanai, Y., & Hirokawa, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.18.9654 · Cited by 153 · see citing works
Kinesin-mediated organelle translocation revealed by specific cellular manipulations.
Feiguin, F. M., Ferreira, A., Kosik, K. S., & Cáceres, A. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.4.1021 · Cited by 151 · see citing works
Mitotic Regulation of Microtubule Cross-Linking Activity of CENP-E Kinetochore Protein
Liao, H., Li, G., & Yen, T. J. (1994) · Science · doi:10.1126/science.8023161 · Cited by 146 · see citing works
Organelle transport along microtubules — the role of KIFs
Hirokawa, N. (1996) · Trends in Cell Biology · doi:10.1016/0962-8924(96)10003-9 · Cited by 131 · see citing works
A rat monoclonal antibody reacting specifically with the tyrosylated form of alpha-tubulin. II. Effects on cell movement, organization of microtubules, and intermediate filaments, and arrangement of Golgi elements.
Wehland, J., & Willingham, M. C. (1983) · The Journal of Cell Biology · doi:10.1083/jcb.97.5.1476 · Cited by 127 · see citing works
Phosphorylation of Kinesin inVivo Correlates with Organelle Association and Neurite Outgrowth
Lee, K.-D., & Hollenbeck, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.10.5600 · Cited by 113 · see citing works
The carboxyl-terminal domain of kinesin heavy chain is important for membrane binding
Skoufias, D. A., Cole, D. G., Wedaman, K. P., & Scholey, J. M. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)42281-2 · Cited by 110 · see citing works
Phosphorylation of Neuronal Kinesin Heavy and Light Chains In Vivo
Hollenbeck, P. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03513.x · Cited by 109 · see citing works
Calmodulin binding to and cAMP-dependent phosphorylation of kinesin light chains modulate kinesin ATPase activity
Matthies, H. J., Miller, R. J., & Palfrey, H. C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82108-1 · Cited by 108 · see citing works
Throttles and Dampers: Controlling the Engine of Membrane Fusion
Rothman, J. E., & Söllner, T. H. (1997) · Science · doi:10.1126/science.276.5316.1212 · Cited by 107 · see citing works
Molecular cloning of a novel protein‐tyrosine phosphatase containing a membrane‐binding domain and GLGF repeats
Maekawa, K., Imagawa, N., Nagamatsu, M., & Harada, S. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80273-4 · Cited by 107 · see citing works
Characterization of KIFC2, a Neuronal Kinesin Superfamily Member in Mouse
Hanlon, D., Yang, Z., & Goldstein, L. S. B. (1997) · Neuron · doi:10.1016/s0896-6273(00)81244-1 · Cited by 97 · see citing works
Cytoplasmic dynein undergoes intracellular redistribution concomitant with phosphorylation of the heavy chain in response to serum starvation and okadaic acid.
Lin, S. X., Ferro, K., & Collins, C. A. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.127.4.1009 · Cited by 87 · see citing works
Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain.
Møller, N. P. H., Møller, K. B., Lammers, R., et al. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7477 · Cited by 82 · see citing works
Self-citation
Tyrosine Phosphorylation: Past, Present and Future
Hunter, T. R. (1996) · Biochemical Society Transactions · doi:10.1042/bst0240307 · Cited by 81 · see citing works
The activation of protein kinase A pathway selectively inhibits anterograde axonal transport of vesicles but not mitochondria transport or retrograde transport in vivo
Okada, Y., Sato-Yoshitake, R., & Hirokawa, N. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-04-03053.1995 · Cited by 72 · see citing works
AF-6/cno: neither a kinesin nor a myosin, but a bit of both
Ponting, C. P. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89040-4 · Cited by 69 · see citing works
Pez - A Novel Human cDNA Encoding Protein Tyrosine Phosphatase- and Ezrin-Like Domains
Smith, A. L., Mitchell, P. J., SHIPLEY, J. M., Gusterson, B. A., Rogers, M. V., & Crompton, M. R. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.1591 · Cited by 55 · see citing works
KLP38B: A Mitotic Kinesin-related Protein That Binds PP1
Alphey, L., Parker, L., Hawcroft, G., Guo, Y., Kaiser, K., & Morgan, G. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.138.2.395 · Cited by 53 · see citing works
Role of motor proteins in organizing the endoplasmic reticulum and Golgi apparatus
Allan, V. (1996) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1996.0043 · Cited by 29 · see citing works
Characterization of a Kinesin-Related Gene ATSV, within the Tuberous Sclerosis Locus (TSC1) Candidate Region on Chromosome 9Q34
Furlong, R. A., Zhou, C., Ferguson-Smith, M. A., et al. (1996) · Genomics · doi:10.1006/geno.1996.0217 · Cited by 22 · see citing works

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Authors: Dorner, C., Ciossek, T., Müller, S., Møller, N. P. H., Ullrich, A., & Lammers, R.
Affiliations: Max Planck Society (DE)
Max Planck Institute of Biochemistry (DE)
Corresponding author: Lammers, Reiner
ORCID: Ciossek, Thomas
Venue: Journal of Biological Chemistry
Publisher: Elsevier BV
Published: 1998-08
Volume: 273
Issue: 32
Pages: 20267-20275
ISSN: 0021-9258 (ISSN-L)
DOI: 10.1074/jbc.273.32.20267
OpenAlex: W2046583364
Cited by: 136
References: 60
Citations by year: 2025: 4 · 2024: 6 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 5
FWCI: 3.72
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 8110 d)
Locations: Journal of Biological Chemistry (publishedVersion, cc-by)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Keywords: KIF1C, Golgi apparatus, endoplasmic reticulum, vesicle trafficking, tyrosine phosphorylation, brefeldin A, microtubule transport
MeSH terms: Amino Acid Sequence, Animals, Anti-Bacterial Agents, Cells, Cultured, Cloning, Molecular, Cyclopentanes, Endoplasmic Reticulum, Fluorescent Antibody Technique, Golgi Apparatus, Humans, Microtubules, Molecular Sequence Data, Phosphorylation, RNA, Messenger, Kinesins, Protein Tyrosine Phosphatases, Sequence Homology, Amino Acid, Sequence Analysis, DNA, Macrolides, Phosphotyrosine, Brefeldin A, Mice, Rats

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Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum

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