The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Evidence That DOCK180 Up-regulates Signals from the CrkII-p130Cas Complex
Open accessAbstract
DOCK180 is one of the two principal proteins bound to the SH3 domain of the adaptor protein CrkII. Here, we have studied the involvement of DOCK180 in integrin signaling. DOCK180 was neither phosphorylated nor bound to CrkII in quiescent NIH 3T3 cells and 3Y1 cells. We found that DOCK180 was phosphorylated and bound to CrkII in NIH 3T3 cells stimulated with integrin and also in 3Y1 cells transformed by v-src or v-crk. The binding of DOCK180 to CrkII correlated with the binding of CrkII to p130(Cas), which is a major CrkII SH2 domain-binding protein at focal adhesions. In a reconstitution experiment, expression of DOCK180 induced hyperphosphorylation of p130(Cas) and a concomitant increase in the amount of CrkII bound to p130(Cas). Similarly, binding of DOCK180 to CrkII was also enhanced by the coexpression of p130(Cas). Finally, we found that coexpression of p130(Cas) and CrkII with DOCK180 induced local membrane spreading and accumulation of DOCK180-CrkII-p130(Cas) complexes at focal adhesions. These findings suggest that DOCK180 positively regulates signaling from integrins to CrkII-p130(Cas) complexes at focal adhesions.
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Cites
Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
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Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,373
Frisch, S. M., & Screaton, R. A. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00251-9 · Cited by 1,249
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Schmitz, A. A. P., Govek, E.-E., Böttner, B., & Van Aelst, L. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.5049 · Cited by 578
Unconventional Rac-GEF activity is mediated through the Dock180–ELMO complex
Brugnera, E., Haney, L., Grimsley, C., Lu, M., Walk, S. F., Tosello-Trampont, A.-C., Macara, I. G., Madhani, H., Fink, G. R., & Ravichandran, K. S. (2002) · Nature Cell Biology · doi:10.1038/ncb824 · Cited by 576
Gumienny, T. L., Brugnera, E., Tosello-Trampont, A.-C., Kinchen, J. M., Haney, L. B., Nishiwaki, K., Walk, S. F., Nemergut, M. E., Macara, I. G., Francis, R., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00520-7 · Cited by 568
Metadata
- Authors
- Kiyokawa, E., Hashimoto, Y., Kurata, T., Sugimura, H., & Matsuda, M.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-09
- Volume
- 273
- Issue
- 38
- Pages
- 24479-24484
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2034752841
- Cited by
- 208
- References
- 1
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Kiyokawa, E., Hashimoto, Y., Kurata, T., Sugimura, H., & Matsuda, M. (1998). Evidence That DOCK180 Up-regulates Signals from the CrkII-p130Cas Complex. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.38.24479
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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