Protein modules and signalling networks
Abstract
Communication between cells assumes particular importance in multicellular organisms. The growth, migration and differentiation of cells in the embryo, and their organization into specific tissues, depend on signals transmitted from one cell to another. In the adult, cell signalling orchestrates normal cellular behaviour and responses to wounding and infection. The consequences of breakdowns in this signalling underlie cancer, diabetes and disorders of the immune and cardiovascular systems. Conserved protein domains that act as key regulatory participants in many of these different signalling pathways are highlighted.
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The PPPPY sequence in LRAD3 may also be recognized by molecules containing SH3 domains.
“Interestingly, not only does the PPPPY sequence in LRAD3 conform to the WW domain binding consensus, but this region may also be recognized by molecules containing src homology 3 (SH3) domains (Pawson and Scott, 1997; Pawson, 1995; Cohen et al., 1995).”
From LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking (2011) · cites this paper as Pawson, 1995
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“Interestingly, not only does the PPPPY sequence in LRAD3 conform to the WW domain binding consensus, but this region may also be recognized by molecules containing Src homology 3 (SH3) domains (Cohen et al., 1995; Pawson, 1995; Pawson and Scott, 1997).”
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- Authors
- Pawson, T.
- Affiliations
- Mount Sinai Hospital (CA)
- Corresponding author
- Pawson, Tony
- Venue
- Nature
- Published
- 1995-02
- Volume
- 373
- Issue
- 6515
- Pages
- 573-580
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1982186905
- Cited by
- 2,420
- References
- 2
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 17 · 2023: 12 · 2022: 19 · 2021: 27 · 2020: 35 · 2019: 27 · 2018: 26 · 2017: 21 · 2016: 32 · 2015: 30 · 2014: 33 · 2013: 43 · 2012: 39
- FWCI
- 24.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Keywords
- protein modules, signaling networks, signal transduction, protein domains, multicellular organisms, cancer, diabetes mellitus, immune disorders, cardiovascular disease, tissue organization
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Blood Proteins, Cell Communication, Humans, Molecular Sequence Data, Phosphoproteins, Protein Binding, Proteins, Receptors, Cell Surface, Signal Transduction, Proto-Oncogene Proteins pp60(c-src)
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