The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ
Open accessAbstract
Fat cell differentiation is a critical aspect of obesity and diabetes. Dietary fatty acids are converted to arachidonic acid, which serves as precursor of prostaglandins (PGs). PGJ2 derivatives function as activating ligands for peroxisome proliferator-activated receptor gamma (PPAR gamma), a nuclear hormone receptor that is central to adipogenic determination. We report here that PGF2 alpha blocks adipogenesis through activation of mitogen-activated protein kinase, resulting in inhibitory phosphorylation of PPAR gamma. Both mitogen-activated protein kinase activation and PPAR gamma phosphorylation are required for the anti-adipogenic effects of PGF2 alpha. Thus, PG signals generated at a cell surface receptor regulate the program of gene expression required for adipogenesis by modulating the activity of a nuclear hormone receptor that is directly activated by other PG signals. The balance between PGF2 alpha and PGJ2 signaling may thus be central to the development of obesity and diabetes.
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Retinoic Acid Blocks Adipogenesis by Inhibiting C/EBPβ-Mediated Transcription
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Ricote, M., Huang, J., Fajas, L., Li, A., Welch, J., Najib, J., Witztum, J. L., Auwerx, J., Palinski, W., & Glass, C. K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7614 · Cited by 721
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Self-citationCottam, D. R., Mattar, S. G., Barinas-Mitchell, E., Eid, G., Kuller, L., Kelley, D. E., & Schauer, P. R. (2004) · Obesity Surgery · doi:10.1381/096089204323093345 · Cited by 461
Li, M., Pascual, G., & Glass, C. K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4699-4707.2000 · Cited by 377
Interdomain communication regulating ligand binding by PPAR-γ
Shao, D., Rangwala, S. M., Bailey, S. T., Krakow, S. L., Reginato, M. J., & Lazar, M. A. (1998) · Nature · doi:10.1038/24634 · Cited by 349
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Metadata
- Authors
- Reginato, M. J., Krakow, S. L., Bailey, S. T., & Lazar, M. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-01
- Volume
- 273
- Issue
- 4
- Pages
- 1855-1858
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1982460743
- Cited by
- 277
- References
- 6
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Reginato, M. J., Krakow, S. L., Bailey, S. T., & Lazar, M. A. (1998). Prostaglandins Promote and Block Adipogenesis through Opposing Effects on Peroxisome Proliferator-activated Receptor γ. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.4.1855
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
