The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Broad Spectrum Antimicrobial Biocides Target the FabI Component of Fatty Acid Synthesis
Open accessAbstract
The broad spectrum antibacterial properties of 2-hydroxydiphenyl ethers have been appreciated for decades, and their use in consumer products is rapidly increasing. We identify the enoyl-acyl carrier protein reductase (fabI) component of the type II fatty acid synthase system as the specific cellular target for these antibacterials. Biologically active 2-hydroxydiphenyl ethers effectively inhibit fatty acid synthesis in vivo and FabI activity in vitro. Resistant mechanisms include up-regulation of fabI expression and spontaneously arising missense mutations in the fabI gene. These results contradict the view that these compounds directly disrupt membranes and suggest that their widespread use will select for resistant bacterial populations.
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Cited by
THE STRUCTURAL BIOLOGY OF TYPE II FATTY ACID BIOSYNTHESIS
White, S. W., Zheng, J., Zhang, Y.-M., & Rock, C. O. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133524 · Cited by 832
Self-citationBacterial Fatty Acid Biosynthesis: Targets for Antibacterial Drug Discovery
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Lipid biosynthesis as a target for antibacterial agents
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Metadata
- Authors
- Heath, R. J., Yu, Y.-T., Shapiro, M. A., Olson, E., & Rock, C. O.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 273
- Issue
- 46
- Pages
- 30316-30320
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2046348365
- Cited by
- 337
- References
- 21
- FWCI
- 11.83
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Heath, R. J., Yu, Y.-T., Shapiro, M. A., Olson, E., & Rock, C. O. (1998). Broad Spectrum Antimicrobial Biocides Target the FabI Component of Fatty Acid Synthesis. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.273.46.30316
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
