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XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

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RB1CC1 Protein Positively Regulates Transforming Growth Factor-β Signaling through the Modulation of Arkadia E3 Ubiquitin Ligase Activity

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A Zebrafish Chemical Suppressor Screening Identifies Small Molecule Inhibitors of the Wnt/β-catenin Pathway

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Ectopic Expression of Axin Blocks Neuronal Differentiation of Embryonic Carcinoma P19 Cells

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Wingless‐type frizzled protein receptor signaling and its putative role in human colon cancer

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The scaffold protein AXIN1: gene ontology, signal network, and physiological function

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Bidirectional induction toward paraxial mesodermal derivatives from mouse ES cells in chemically defined medium

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Understanding the somitogenesis clock: What’s missing?

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The canonical Wnt signaling pathway is not involved in renal cyst development in the kidneys of inv mutant mice

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Regulation of Wnt Signalling by Receptor-mediated Endocytosis

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Adenomatous Polyposis Coli Is Down-regulated by the Ubiquitin-Proteasome Pathway in a Process Facilitated by Axin

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Beyond cell adhesion: The role of armadillo proteins in the heart

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The adenomatous polyposis coli protein (APC) exists in two distinct soluble complexes with different functions

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Regulating the response to targeted MEK inhibition in melanoma

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Glycogen synthase kinase-3β (GSK-3β) and its dysregulation in glioblastoma multiforme

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The adenomatous polyposis coli protein.

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Resveratrol attenuates hyperoxia‐induced oxidative stress, inflammation and fibrosis and suppresses Wnt/β‐catenin signalling in lungs of neonatal rats

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Regulation of Wnt signaling by protocadherins

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Inhibitory effect of a presenilin 1 mutation on the Wnt signalling pathway by enhancement of β‐catenin phosphorylation

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Reversible Modification of Adenomatous Polyposis Coli (APC) with K63-linked Polyubiquitin Regulates the Assembly and Activity of the β-Catenin Destruction Complex

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Vertebrate Axial Patterning: From Egg to Asymmetry

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GSK3β: A master switch and a promising target

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Clinicopathological Analysis of β-catenin and Axin-1 in Solid Pseudopapillary Neoplasms of the Pancreas

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Putative signaling action of amelogenin utilizes the Wnt/β‐catenin pathway

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Nuclear Localization of Duplin, a β-Catenin-binding Protein, Is Essential for Its Inhibitory Activity on the Wnt Signaling Pathway

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Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer

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miR-103 inhibits proliferation and sensitizes hemopoietic tumor cells for glucocorticoid-induced apoptosis

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APC and β-Catenin Degradation

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GSK3 is a negative regulator of the transcriptional coactivator MAML1

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p120-catenin in canonical Wnt signaling

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Traffic jam in the primitive streak: The role of defective mesoderm migration in birth defects

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Toggling a Conformational Switch in Wnt/β-catenin Signaling: Regulation of Axin Phosphorylation

Tacchelly-Benites, O., Wang, Z.-H., Yang, E., Lee, E., & Ahmed, Y. (2013) · Bioessays · doi:10.1002/bies.201300101 · Cited by 32

Axin phosphorylation in both Wnt-off and Wnt-on states requires the tumor suppressor APC

Tacchelly‐Benites, O., Wang, Z., Yang, E., Benchabane, H., Tian, A., Randall, M. P., & Ahmed, Y. F. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007178 · Cited by 29

Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma

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Reduced expression of FILIP1L, a novel WNT pathway inhibitor, is associated with poor survival, progression and chemoresistance in ovarian cancer

Kwon, M., Kim, J., Rybak, Y., Luna, A., Choi, C. H., Chung, J., Hewitt, S. M., Adem, A., Tubridy, E., Lin, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.12784 · Cited by 28

miR-155 Is Downregulated in Familial Adenomatous Polyposis and Modulates WNT Signaling by Targeting AXIN1 and TCF4

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Inhibition of Glycogen Synthase Kinase-3

Ougolkov, A. V., & Billadeau, D. D. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-249-6_5 · Cited by 27

WSB1 regulates c-Myc expression through β-catenin signaling and forms a feedforward circuit

Gao, X., You, J., Gong, Y., Meng, Y. G., Zhu, H., Fang, L., Zhu, H., Ying, M., He, Q., Yang, B., et al. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.10.021 · Cited by 29

IGFBP‐3 inhibits Wnt signaling in metastatic melanoma cells

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Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes

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Wnt Signaling Polarizes C. elegans Asymmetric Cell Divisions During Development

Lam, A. K., & Phillips, B. T. (2017) · Results and problems in cell differentiation · doi:10.1007/978-3-319-53150-2_4 · Cited by 25

GSK3β/Axin-1/β-Catenin Complex Is Involved in Semaphorin3A Signaling

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Axin negatively affects tau phosphorylation by glycogen synthase kinase 3β

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The enormous influence of TNIK knockdown on intracellular signals and cell survival

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Insights into unbinding mechanisms upon two mutations investigated by molecular dynamics study of GSK3β–axin complex: Role of packing hydrophobic residues

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Aurora‐A enhances malignant development of esophageal squamous cell carcinoma (ESCC) by phosphorylating β‐catenin

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NSAIDs and Cell Proliferation in Colorectal Cancer

Ettarh, R. R., Cullen, A., & Calamai, A. (2010) · Pharmaceuticals · doi:10.3390/ph3072007 · Cited by 22

HDAC I inhibitor regulates RUNX2 transactivation through canonical and non-canonical Wnt signaling in aortic valvular interstitial cells.

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Multilevel regulation of Wnt signaling by Zic2 in colon cancer due to mutation of β-catenin

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Role of the Wnt/β-Catenin Pathway in Renal Osteodystrophy

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Diversity of axin in signaling pathways and its relation to colorectal cancer

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CyclinD1 protein expressed in pterygia is associated with β-catenin protein localization.

Tung, J. N., Chiang, C. C., Tsai, Y.-Y., Chou, Y.-Y., Yeh, K. T., Lee, H., & Cheng, Y. W. (2010) · PubMed Central · Cited by 20

Dual Roles for Membrane Association of Drosophila Axin in Wnt Signaling

Wang, Z., Tacchelly‐Benites, O., Yang, E., & Ahmed, Y. F. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006494 · Cited by 20

Axin Family of Scaffolding Proteins in Development: Lessons from C. elegans

Mallick, A., Taylor, S. K. B., Ranawade, A., & Gupta, B. P. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7040020 · Cited by 20

Both the RGS Domain and the Six C-Terminal Amino Acids of Mouse Axin Are Required for Normal Embryogenesis

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Cadherins and catenins, Wnts and SOXs: Embryonic patterning in Xenopus

Amand, A. L. S., & Klymkowsky, M. W. (2001) · International review of cytology · doi:10.1016/s0074-7696(01)03010-8 · Cited by 20

Glycogen Synthase Kinase-3 Interaction Domain Enhances Phosphorylation of SARS-CoV-2 Nucleocapsid Protein

Yun, J. S., Kim, N. H., 송혜은, Cha, S. Y., Hwang, K. H., Lee, J. E., Jeong, C.-H., Song, S. H., Kim, S., Cho, E. S., et al. (2022) · Molecules and Cells · doi:10.14348/molcells.2022.0130 · Cited by 19

Upregulation of Glycogen Synthase Kinase 3β in Human Colorectal Adenocarcinomas Correlates With Accumulation of CTNNB1

Wang, H. L., Hart, J. A. L., Fan, L., Mustafi, R., & Bissonnette, M. (2011) · Clinical Colorectal Cancer · doi:10.3816/ccc.2011.n.004 · Cited by 19

MGAT1 is a novel transcriptional target of Wnt/β-catenin signaling pathway

Akiva, İ., & İyison, N. B. (2018) · BMC Cancer · doi:10.1186/s12885-017-3960-7 · Cited by 19

TRIM-endous functional network of tripartite motif 29 (TRIM29) in cancer progression and beyond

Wu, Q., Nandi, D., & Sharma, D. (2024) · Cancer and Metastasis Reviews · doi:10.1007/s10555-024-10226-2 · Cited by 22

Feedback in the β-catenin destruction complex imparts bistability and cellular memory

Cantoria, M. J., Alizadeh, E., Ravi, J., Varghese, R. P., Bunnag, N., Pond, K. W., Kettenbach, A. N., Ahmed, Y. F., Paek, A. L., Tyson, J. J., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2208787120 · Cited by 18

Intranasal wnt-3a alleviates neuronal apoptosis in early brain injury post subarachnoid hemorrhage via the regulation of wnt target PPAN mediated by the moonlighting role of aldolase C

Ruan, W., Hu, J., Zhou, H., Yin, L., Xu, C., Luo, Y., Chen, T., Xu, B., Yan, F., & Chen, G. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.104656 · Cited by 18

Cyclin-dependent kinase 2 regulates the interaction of Axin with β-catenin

Kim, S. I., Park, C. S., Lee, M. S., Kwon, M. S., Jho, E., & Song, W. K. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.03.065 · Cited by 18

Regulation of Skeletal Muscle Plasticity by Glycogen Synthase Kinase-3β: A Potential Target for the Treatment of Muscle Wasting

Verhees, K. J. P., Pansters, N. A. M., Schols, A. M. W. J., & LANGEN, R. C. J. (2013) · Current Pharmaceutical Design · doi:10.2174/1381612811319180011 · Cited by 19

The critical role of calcineurin/NFAT (C/N) pathways and effective antitumor prospect for colorectal cancers

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A Biochemical Screen for Identification of Small-Molecule Regulators of the Wnt Pathway Using Xenopus Egg Extracts

Thorne, C. A., LaFleur, B., Lewis, M., Hanson, A. J., Jernigan, K. K., Weaver, D. C., Huppert, K. A., Chen, T. W., Wichaidit, C., Cselenyi, C. S., et al. (2011) · SLAS DISCOVERY · doi:10.1177/1087057111416657 · Cited by 18

Feedback control of Wnt signaling based on ultrastable histidine cluster co-aggregation between Naked/NKD and Axin

Gammons, M. V. R., Renko, M., Flack, J. E., Mieszczanek, J., & Bienz, M. (2020) · eLife · doi:10.7554/elife.59879 · Cited by 17

Wild-Type BRCA1, but not Mutated BRCA1, Regulates the Expression of the Nuclear Form of β-Catenin

Li, H., Sekine, M., Tung, N., & Avraham, H. K. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0403 · Cited by 18

Shaping Brassinosteroid Signaling through Scaffold Proteins

Guo, B., Kim, E., Zhu, Y., Wang, K., & Russinova, E. (2024) · Plant and Cell Physiology · doi:10.1093/pcp/pcae040 · Cited by 16

An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function

Mazzoni, S. M., Petty, E. M., Stoffel, E. M., & Fearon, E. R. (2015) · Neoplasia · doi:10.1016/j.neo.2015.04.006 · Cited by 16

Liquid–liquid phase separation drives the β‐catenin destruction complex formation

Shi, Q., Kang, K., & Chen, Y. (2021) · BioEssays · doi:10.1002/bies.202100138 · Cited by 15

Phosphorylation of PPP(S/T)P motif of the free LRP6 intracellular domain is not required to activate the Wnt/β‐catenin pathway and attenuate GSK3β activity

Beagle, B. R., Mi, K., & Johnson, G. V. W. (2009) · Journal of Cellular Biochemistry · doi:10.1002/jcb.22318 · Cited by 15

Differential Role of Axin RGS Domain Function in Wnt Signaling during Anteroposterior Patterning and Maternal Axis Formation

Schneider, P. N., Slusarski, D. C., & Houston, D. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044096 · Cited by 15

NGF-dependent formation of ruffles in PC12D cells required a different pathway from that for neurite outgrowth

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Biochemical characterization of the Drosophila Axin protein

Yanagawa, S.-I., Lee, J.-S., Matsuda, Y., & Ishimoto, A. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01601-x · Cited by 15

Maternal Proteins That Are Phosphoregulated upon Egg Activation Include Crucial Factors for Oogenesis, Egg Activation and Embryogenesis in Drosophila melanogaster

Zhang, Z., Krauchunas, A. R., Huang, S., & Wolfner, M. F. (2018) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200578 · Cited by 12

Inhibitory effect of selected Indian honey on colon cancer cell growth by inducing apoptosis and targeting the β-catenin/Wnt pathway

Das, N., Ray, N., PATIL, A. R., Saini, S. S., Waghmode, B., Ghosh, C., Patil, S. B., Patil, S. B., Mote, C., Saini, S. K., et al. (2022) · Food & Function · doi:10.1039/d1fo03727g · Cited by 15

Membrane Bound Axin Is Sufficient for Wingless Signaling in Drosophila Embryos

Tolwinski, N. S. (2009) · Genetics · doi:10.1534/genetics.108.098236 · Cited by 14

Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin

Gillis, W. J., Kirmizitas, A., Iwasaki, Y., Ki, D. H., Wyrick, J. M., & Thomsen, G. H. (2016) · Cell Communication and Signaling · doi:10.1186/s12964-016-0138-x · Cited by 14

Sulindac Sulfide Reverses Aberrant Self-Renewal of Progenitor Cells Induced by the AML-Associated Fusion Proteins PML/RARα and PLZF/RARα

Steinert, G., Oancea, C., Roos, J., Hagemeyer, H., Maier, T. J., Ruthardt, M., & Puccetti, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022540 · Cited by 13

TGF-β2 antisense oligonucleotide enhances T-cell mediated anti-tumor activities by IL-2 via attenuation of fibrotic reaction in a humanized mouse model of pancreatic ductal adenocarcinoma

Lee, H. K., Nam, M.-W., Go, R., Koo, J., Kim, T. H., Park, J.-E., & Choi, K. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.114212 · Cited by 15

Wnt/β‐catenin‐mediated transcriptional regulation

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Splice variants of CK1α and CK1α-like: Comparative analysis of subcellular localization, kinase activity, and function in the Wnt signaling pathway

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Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor

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