Phosphorylation of Axin, a Wnt Signal Negative Regulator, by Glycogen Synthase Kinase-3β Regulates Its Stability

Identification of c- MYC as a Target of the APC Pathway

He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566

Functional interaction of β-catenin with the transcription factor LEF-1

Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912

Wnt signaling: a common theme in animal development

Cadigan, K. M., & Nusse, R. (1997) · Genes & Development · doi:10.1101/gad.11.24.3286 · Cited by 2,567

A molecular mechanism for the effect of lithium on development.

Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,334

XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos

Molenaar, M., van de Wetering, M., Oosterwegel, M., Peterson-Maduro, J., Godsave, S., Korinek, V., Roose, J., Destrée, O., & Clevers, H. (1996) · Cell · doi:10.1016/s0092-8674(00)80112-9 · Cited by 1,824

Binding of GSK3β to the APC-β-Catenin Complex and Regulation of Complex Assembly

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Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

Stambolic, V., Ruel, L., & Woodgett, J. R. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70790-2 · Cited by 1,321

Functional Interaction of an Axin Homolog, Conductin, with β-Catenin, APC, and GSK3β

Behrens, J., Jerchow, B., Würtele, M., Grimm, J., Asbrand, C., Wirtz, R. M., Kühl, M., Wedlich, D., & Birchmeier, W. (1998) · Science · doi:10.1126/science.280.5363.596 · Cited by 1,255

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3.Preprint

Yost, C., Torres, M., Miller, J., Huang, E., Kimelman, D., & Moon, R. T. (1996) · Genes & Development · doi:10.1101/gad.10.12.1443 · Cited by 1,167

N-terminal phosphorylation regulates the activity of glycogen synthase kinase 3 from Plasmodium falciparum

Pažický, S., Alder, A., Mertens, H. D. T., Svergun, D. I., Gilberger, T., & Löw, C. (2022) · Biochemical Journal · doi:10.1042/bcj20210829 · Cited by 6

Clotrimazole inhibits the Wnt/β-catenin pathway by activating two eIF2α kinases: The heme-regulated translational inhibitor and the double-stranded RNA-induced protein kinase

Yonezawa, H., Ogawa, M., Katayama, S., Shimizu, Y., Omori, N., Oku, Y., Sakyo, T., Uehara, Y., & Nishiya, N. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.10.053 · Cited by 6

Protein Kinases Involved in the Regulation of Wnt/β-catenin Signaling

Shin, E., Park, E. C., Hong, Y., & Kim, G. (2013) · Journal of Life Science · doi:10.5352/jls.2013.23.7.947 · Cited by 5

The Role of Glycogen Synthase Kinase 3 in the Mechanisms of Learning and Memory

Grigoryan, G. A. (2014) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-014-0023-2 · Cited by 6

Structural Basis of the Interaction between Human Axin2 and SIAH1 in the Wnt/β-Catenin Signaling Pathway

Chen, L., Liu, Y., Tian, L., Li, M., Yang, S., Wang, S., Xu, W., & Yan, X. (2023) · Biomolecules · doi:10.3390/biom13040647 · Cited by 4

Mathematical modelling of the Wnt-pathway

Heinrich, R. (2005) · Springer eBooks · doi:10.1007/b136811 · Cited by 4

Cloning and analysis of RECK during early Xenopus laevis development

Willson, J. A. (2012) · Scholarship@Western (Western University) · Cited by 3

Glycogen Synthase Kinase-3 in Neurological Diseases

Kaidanovich‐Beilin, O., & Woodgett, J. R. (2012) · Neuromethods · doi:10.1007/978-1-61779-824-5_9 · Cited by 3

S-SCAM inhibits Axin-dependent synaptic function of GSK3β in a sex-dependent manner

Kearney, G., Grau, D., Torres, D. N., Shin, S. M., & Lee, S. H. (2022) · Scientific Reports · doi:10.1038/s41598-022-08220-1 · Cited by 3

Role of Glycogen Synthase Kinase-3 in Mechanisms of Learning and Memory

Grigoryan, G. A. (2013) · Журнал высшей нервной деятельности им И П Павлова · doi:10.7868/s0044467713050043 · Cited by 3

Wnt Signal Transduction in the Cytoplasm

Chen, T. W., Wallace, H. A., Ahmed, Y. F., & Lee, E. N. (2014) · Wiley eBooks · doi:10.1002/9781118444122.ch3 · Cited by 4

Co-Translational Sorting Enables a Single mRNA to Generate Distinct Polysomes with Different Localizations and Protein FatesPreprint

Salloum, S., Sevéno, M., Koulali, K. E., Rialle, S., George, S., Lemmers, B., Zibara, K., Eliscovich, C., Hahne, M., & Bertrand, É. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.03.20.585881 · Cited by 2

Developmental Signaling Networks

Bommer, G. T., & Fearon, E. R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00009-9 · Cited by 2

WNT/β-Catenin Signaling in Adrenocortical Carcinoma

Gaujoux, S., Tissier, F., & Bertherat, J. Y. (2009) · Springer eBooks · doi:10.1007/978-0-387-77236-3_16 · Cited by 1

Therapeutic targeting of glycogen synthase kinase-3: Strategy to address neurodegenerative diseases

Noor, S., Raza, A., & Hassan, M. I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91287-7.00008-9 · Cited by 1

Escin Activates Canonical Wnt/β-Catenin Signaling Pathway by Facilitating the Proteasomal Degradation of Glycogen Synthase Kinase-3β in Cultured Human Dermal Papilla Cells

Shin, J. Y., Kim, J. J., Choi, Y.-H., Lee, S.-H., & Kang, N. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45070373 · Cited by 1

The CK 1ε/ SIAH1 axis regulates AXIN 1 stability in colorectal cancer cells

Yan, M., Su, Z., Pang, X., Wang, H., Dai, H., Ning, J., Liu, S., Sun, Q., Song, J., Zhao, X., et al. (2024) · Molecular Oncology · doi:10.1002/1878-0261.13624 · Cited by 1

Noncanonical Wnt Signaling and Neural

Montcouquiol, M., & Kelley, M. W. (2006) · Cited by 1

Identification of protein phosphatase 4 catalytic subunit as a Wnt promoting factor in pan-cancer and Xenopus early embryogenesis

Wang, Y., Han, W., Yun, S., & Han, J. (2023) · Scientific Reports · doi:10.1038/s41598-023-35719-y · Cited by 1

On the use of process algebra techniques in computational modelling of cancer initiation and development

Schaeffer, O. (2008) · University of Birmingham Institutional Research Archive (University of Birmingham) · Cited by 1

Dorsal determinant Hwa stabilizes β-catenin through direct inhibition of GSK3Preprint

Ji, L., Chin, C. V., Sun, G., Charlats, O., Vickers, C., Lu, B., Sigoillot, F. D., Wang, Z., Xu, W., & Cong, F. (2025) · Genes & Development · doi:10.1101/gad.352622.125 · Cited by 1

Functional Consequences of Complete GSK-3 Ablation in Mouse Embryonic Fibroblasts

Miron, I. M. (2008) · TSpace (University of Toronto) · Cited by 1

Regulation of neuritogenesis in neuroblastoma cells by components of the WNT signalling pathway.

Orme, M. H. (2002) · OpenGrey (Institut de l'Information Scientifique et Technique)

Kidney Induction: Control by Notch, Wnt and GDNF/Ret signalling

Kuure, S. (2007) · Työväentutkimus Vuosikirja

Resolving mechanisms of apoptosis in response to WNT3A in Melanoma

Conrad, W. H. (2012) · ResearchWorks at the University of Washington (University of Washington)

Glycogen Synthase Kinase 3 Influences Cell Motility and Chemotaxis by Regulating Phosphatidylinositol 3 Kinase Localization in Dictyostelium discoideum

Sun, T. (2013) · FIU - Digital Commons (Florida International University) · doi:10.25148/etd.fi13040103

Molecular Mechanisms Underlying Pluripotency and Lineage Commitment – The Role of GSK-3

Bradley, W. H., Kevin, F., & James, R. (2011) · InTech eBooks · doi:10.5772/23842 · Cited by 1

Specific Serum-free Conditions can Differentiate Mouse Embryonic Stem Cells into Osteochondrogenic and Myogenic Progenitors.

Sakurai, H., Inami, Y., Nishio, N., Ito, S., Yoshikai, T., Suzuki, H., & Isobe, K.-I. (2009) · InTech eBooks · doi:10.5772/7006

Therapeutic Targets in Colorectal Cancer

Ettarh, R. R., Calamai, A., & Culle, A. (2012) · InTech eBooks · doi:10.5772/29610

A Role for AXIN2 in Oncogenesis.

Mazzoni, S. M. (2014) · Deep Blue (University of Michigan)

Ubiquitin & Wnt: The diverse roles of ubiquitin in canonical Wnt signalling

Schmidt, R. E. (2013) · Utrecht University Repository (Utrecht University)

AXIN1 (axin 1)

Pecina-Slaus, N., Nikuseva, M. T., & Kokotović, T. (2012) · Atlas of Genetics and Cytogenetics in Oncology and Haematology · doi:10.4267/2042/46067

Wnt signaling, a novel pathway for coronary artery disease and metabolic syndrome

Mani, A. (2007) · International Cardivascular Research Journal

Alterations in proliferation and differentiation of neural stem cells induced by adverse neurodevelopmental factors

Bose, R. (2014) · Figshare

Regulation of c-Myc phosphorylation, protein stability and oncogenic activity in breast cancer

Zhang, X. (2011) · doi:10.6083/m4pn93m9

B-catenin expression and associated signalling in moderately differentiated human oesophageal squamous carcinoma cell lines

McCutcheon, L. J. G. (2009) · University of the Witwatersrand, Johannesburg Institutional Repository on DSpace (University of the Witwatersrand, Johannesburg)

The effect of expression of estrus at artificial insemination on target genes in the endometrium, conceptus and corpus luteum of beef cows

Davoodi, S. (2015) · cIRcle (University of British Columbia) · doi:10.14288/1.0166263

Role of Axin1 scaffold protein in regulating the c-myc onocoprotein

Krishnamoorthy, A. K. (2012) · doi:10.6083/m4m906nh

Nuclear β-Catenin Signaling as a Target for Anticancer Drug Development

Chung, E. J., Bonvini, P., Oh, H. J., Neckers, L., & Trepel, J. B. (2002) · Cancer drug discovery and develogment/Cancer drug discovery and development · doi:10.1007/978-1-59259-153-4_5

Crosstalk between Insulin and Wnt Signaling Pathways

Sun, J. (2010) · TSpace (University of Toronto)

Wnt Signaling in Skin Development, Homeostasis,

MacDonald, B. T., He, X., Hikasa, H., Sokol, S. Y., Stamos, J. L., Weis, W. I., Cruciat, C., Niehrs, C., Lim, X., Nusse, R., et al. (2014)

The Expression of PI3K, AKT, β-Catenin and VEGFR2 in Medulloblastoma

Lin, X., & Li, Y. (2017) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2017.53004

Integrating regulatory mechanisms of Wnt signaling in development and tissue homeostasis

Hall, E. T. (2017) · Summit (Simon Fraser University)

A Genome-Wide Screen for Wortmannin-Resistant Mutants in Schizosaccharomyces pombe: The Phosphorylation-Impaired Mutants Are Resistant to Signaling Defect

Yılmazer, M., Kartal, B., Tarhan, Ç., Özarabacı, I., Akçaalan, S., Özkan, E., Uzuner, S. K., Arıcan, E., & Palabıyık, B. (2019) · DNA and Cell Biology · doi:10.1089/dna.2019.5003

Replicating adenoviruses targeting tumours with constitutive activation of the Wnt signalling pathway

Fuerer, C. (2004) · reroDoc Digital Library · doi:10.22005/bcu.15988

Developmental Signaling Networks Wnt/β-Catenin Signaling in the Gastrointestinal Tract

Bommer, G. T., & Fearon, E. R. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50011-8

WSB1 Regulates c-Myc Expression Through β-catenin Signaling and Forms a Feedforward Circuit Promoting the Development of CancerPreprint

Gao, X., Gong, Y., You, J., Meng, Y. G., Zhu, H., Fang, L., Zhu, H., Ying, M., He, Q., Yang, B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.25.312678

Novel Biochemical Regulatory Mechanisms of Developmental Signaling Pathways

Chen, T. W. (2014)

N-terminal phosphorylation regulates the activity of Glycogen Synthase Kinase 3 from Plasmodium falciparumPreprint

Pažický, S., Alder, A., Mertens, H. D. T., Svergun, D. I., Gilberger, T., & Löw, C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.06.18.448949

Domestication of chemicals attacking metazoan embryogenesis: identification of safe natural products modifying developmental signaling pathways in human

Nishiya, N., & Yonezawa, H. (2021) · The Journal of Antibiotics · doi:10.1038/s41429-021-00461-y

Molecular Docking Studies to Evaluate Small Molecule Inhibitors of Wnt/Betacatenin Signaling Pathway

Sankari, D. S. S. L., Maka, S. S., Dalal, S., Chanda, C., & Aluru, R. R. (2021) · International Journal of Life Science and Pharma Research · doi:10.22376/ijpbs/lpr.2021.11.5.l122-128

Faculty Opinions recommendation of The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway.

Moon, R. T. (2003) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1015846.198855

Axin

Song, X., & Li, L. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_101525

Axin

Song, X., & Li, L. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_101525-1

WITHDRAWN: Reversible phosphorylation of WOX5 protein controls the homeostasis of QCPreprint

Chen, L. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.13.546412

Mechanism of trypsin-mediated differentiation of pancreatic progenitor cells into functional islet-like clusters

Gao, L., Lai, J.-S., Chen, H., Qian, L.-X., Hong, W.-J., & Li, L.-C. (2025) · World Journal of Diabetes · doi:10.4239/wjd.v16.i6.102727

MEK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesisPreprint

Venkatachalam, N., Wang, L., Muthukumarana, N., Ihnatko, R., Krijgsveld, J., Skabkina, O., Leipertz, A., Chen, Y., Betge, J., Boonekamp, K. E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.13.659446

Some results about the structural properties of the Wnt pathway, its steady states and its non-associative commutative algebra

Vanhaelen, Q. (2025) · Mathematical Medicine and Biology A Journal of the IMA · doi:10.1093/imammb/dqaf008

Generation and analysis of mouse models of aberrant β-catenin function

Cuadrado, P. M. R. (2011) · UCL Discovery (University College London)

Additional file 1 of R-spondin-1 induces Axin degradation via the LRP6-CK1ε axis

Tan, L., Yan, M., Su, Z., Wang, H., Li, H., Zhao, X., Liu, S., Zhang, L., Sun, Q., & Lu, D. (2024) · Figshare · doi:10.6084/m9.figshare.24953177

Étude du rôle de l'AXINE1 dans l'homéostasie et la tumorigenèse de l'épithélium intestinal

Sanson, R. (2021) · theses.fr (ABES) · doi:10.70675/515b91daze7fez40e6z963azd8400c23d0b9

Implication de l'enzyme Glycogène Synthase Kinase 3 dans la médiation des effets diabétogènes des glucocorticoïdes

Delangre, E. (2021) · theses.fr (ABES) · doi:10.70675/622d48edz59dcz427ez85c9z9da5f8129e84

Ras-MAPK inhibition induces AXIN1 loss in colorectal cancer by mTOR associated suppression of protein synthesis

Venkatachalam, N., Wang, L., Muthukumarana, N., Ihnatko, R., Krijgsveld, J., Skabkina, O., Leipertz, A., Chen, Y., Sui, P., Zheng, Q., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02963-4

The Expanding Landscape of Acidophilic Protein Kinases

Cesaro, L., & Salvi, M. (2026) · Kinases and Phosphatases · doi:10.3390/kinasesphosphatases4030026 · Cited by 1

A GSK3β Phosphorylation Site in Axin Modulates Interaction with β-Catenin and Tcf-Mediated Gene Expression

Jho, E., Lomvardas, S., & Costantini, F. D. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.1760 · Cited by 95

Axin prevents Wnt-3a-induced accumulation of β-catenin

Kishida, M., Koyama, S., Kishida, S., Matsubara, K., Nakashima, S., Higano, K., Takada, R., Takada, S., & Kikuchi, A. (1999) · Oncogene · doi:10.1038/sj.onc.1202388 · Cited by 132

Axin Directly Interacts with Plakoglobin and Regulates Its Stability

Kodama, S., Ikeda, S., Asahara, T., Kishida, M., & Kikuchi, A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.39.27682 · Cited by 79

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK‐3β and β‐catenin and promotes GSK‐3β‐dependent phosphorylation of β‐catenin

Ikeda, S., Kishida, S., Yamamoto, H., Murai, H., Koyama, S., & Kikuchi, A. (1998) · The EMBO Journal · doi:10.1093/emboj/17.5.1371 · Cited by 1,248

Wnt signaling: Axin--More Than a Scaffold

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