The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-κB
Open accessAbstract
Ced-4 and Apaf-1 belong to a major class of apoptosis regulators that contain caspase-recruitment (CARD) and nucleotide-binding oligomerization domains. Nod1, a protein with an NH2-terminal CARD-linked to a nucleotide-binding domain and a COOH-terminal segment with multiple leucine-rich repeats, was identified. Nod-1 was found to bind to multiple caspases with long prodomains, but specifically activated caspase-9 and promoted caspase-9-induced apoptosis. As reported for Apaf-1, Nod1 required both the CARD and P-loop for function. Unlike Apaf-1, Nod1 induced activation of nuclear factor-kappa-B (NF-kappaB) and bound RICK, a CARD-containing kinase that also induces NF-kappaB activation. Nod1 mutants inhibited NF-kappaB activity induced by RICK, but not that resulting from tumor necrosis factor-alpha stimulation. Thus, Nod1 is a leucine-rich repeat-containing Apaf-1-like molecule that can regulate both apoptosis and NF-kappaB activation pathways.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Notably, Nod1 mRNA and protein levels in the medulla were almost comparable to those in spleen, which is known to express Nod1 at a high level (Figures 1B, S1A, and S1B), as previously reported (Inohara et al., 1999).”
From Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells (2021) · cites this paper as Inohara et al., 1999
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S. M., Ahmad, M., Alnemri, E. S., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80434-1 · Cited by 7,289
Walker, J. E., Saraste, M., Runswick, M. J., & Gay, N. J. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01276.x · Cited by 5,312
Zou, H., Henzel, W. J., Liu, X., Lutschg, A., & Wang, X. (1997) · Cell · doi:10.1016/s0092-8674(00)80501-2 · Cited by 3,145
Baeuerle, P. A., & Baltimore, D. (1996) · Cell · doi:10.1016/s0092-8674(00)81318-5 · Cited by 3,002
Palombella, V. J., Rando, O. J., Goldberg, A. L., & Maniatis, T. (1994) · Cell · doi:10.1016/s0092-8674(94)90482-0 · Cited by 2,089
Mechanisms And Functions Of Cell Death
Ellis, R. E., Yuan, J., & Horvitz, H. R. (1991) · Annual Review of Cell Biology · doi:10.1146/annurev.cb.07.110191.003311 · Cited by 2,088
The TNF receptor 1-associated protein TRADD signals cell death and NF-κB activation
Hsu, H., Xiong, J., & Goeddel, D. V. (1995) · Cell · doi:10.1016/0092-8674(95)90070-5 · Cited by 2,024
The Receptor for the Cytotoxic Ligand TRAIL
Pan, G., O’Rourke, K. M., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., & Dixit, V. M. (1997) · Science · doi:10.1126/science.276.5309.111 · Cited by 1,755
Self-citationReduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9
Kuida, K., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P., & Flavell, R. A. (1998) · Cell · doi:10.1016/s0092-8674(00)81476-2 · Cited by 1,643
Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling
Yang, R.-B., Mark, M., Gray, A., Huang, A., Xie, M.-H., Zhang, M., Goddard, A., Wood, W., Gurney, A., & Godowski, P. (1998) · Nature · doi:10.1038/26239 · Cited by 1,319
Differential Requirement for Caspase 9 in Apoptotic Pathways In Vivo
Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kägi, D., Khoo, W., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81477-4 · Cited by 1,296
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279
IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK
Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., & Goeddel, D. V. (1997) · Science · doi:10.1126/science.278.5339.866 · Cited by 1,183
TNF-Dependent Recruitment of the Protein Kinase RIP to the TNF Receptor-1 Signaling Complex
Hsu, H., Huang, J., Shu, H.-B., Baichwal, V., & Goeddel, D. V. (1996) · Immunity · doi:10.1016/s1074-7613(00)80252-6 · Cited by 1,182
Identification and Characterization of an IκB Kinase
Régnier, C. H., Song, H. Y., Gao, X., Goeddel, D. V., Cao, Z., & Rothe, M. (1997) · Cell · doi:10.1016/s0092-8674(00)80344-x · Cited by 1,176
Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development
Yoshida, H., Kong, Y., Yoshida, R., Elia, A., Hakem, A., Hakem, R., Penninger, J. M., & Mak, T. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81733-x · Cited by 1,138
Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization
Srinivasula, S. M., Ahmad, M., Fernandes‐Alnemri, T., & Alnemri, E. S. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80095-7 · Cited by 1,119
Caspases: the proteases of the apoptotic pathway
Núñez, G., Benedict, M., Hu, Y., & Inohara, N. (1998) · Oncogene · doi:10.1038/sj.onc.1202581 · Cited by 1,046
Self-citationMolecular Genetics of Plant Disease Resistance
Staskawicz, B. J., Ausubel, F. M., Baker, B., Ellis, J. G., & Jones, J. D. G. (1995) · Science · doi:10.1126/science.7732374 · Cited by 911
Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development
Cecconi, F., Álvarez-Bolado, G., Meyer, B. I., Roth, K. A., & Gruß, P. (1998) · Cell · doi:10.1016/s0092-8674(00)81732-8 · Cited by 894
A structural basis of the interactions between leucine-rich repeats and protein ligands
Kobe, B., & Deisenhofer, J. (1995) · Nature · doi:10.1038/374183a0 · Cited by 745
Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death
Chinnaiyan, A. M., O’Rourke, K. M., Lane, B. R., & Dixit, V. M. (1997) · Science · doi:10.1126/science.275.5303.1122 · Cited by 627
Arch, R. H., Gedrich, R. W., & Thompson, C. B. (1998) · Genes & Development · doi:10.1101/gad.12.18.2821 · Cited by 611
van der Biezen, E. A., & Jones, J. D. G. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70145-9 · Cited by 577
Parniske, M., Hammond-Kosack, K. E., Golstein, C., Thomas, C. M., Jones, D. A., Harrison, K., Wulff, B. B. H., & Jones, J. D. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80470-5 · Cited by 565
RAIDD is a new 'death' adaptor molecule
Duan, H., & Dixit, V. M. (1997) · Nature · doi:10.1038/385086a0 · Cited by 550
The CARD domain: a new apoptotic signalling motif
Hofmann, K. (1997) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(97)01043-8 · Cited by 533
Bcl-X L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation
Hu, Y., Benedict, M., Wu, D., Inohara, N., & Núñez, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4386 · Cited by 530
Self-citationCaspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex
Pan, G., O’Rourke, K. M., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5841 · Cited by 522
The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor
Wong, B. R., Josien, R., Lee, S. Y., Vologodskaia, M., Steinman, R. M., & Choi, Y. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.43.28355 · Cited by 458
RIP2 Is a Novel NF-κB-activating and Cell Death-inducing Kinase
McCarthy, J. V., Ni, J., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.27.16968 · Cited by 437
Self-citationThe A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein.
Opipari, A. W., Boguski, M. S., & Dixit, V. M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77165-2 · Cited by 419
Proteins with leucine-rich repeats
Kobe, B., & Deisenhofer, J. (1995) · Current Opinion in Structural Biology · doi:10.1016/0959-440x(95)80105-7 · Cited by 392
Koseki, T., Inohara, N., Chen, S., & Núñez, G. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.9.5156 · Cited by 352
Self-citationInteraction and Regulation of Subcellular Localization of CED-4 by CED-9
Wu, D., Wallen, H. D., & Núñez, G. (1997) · Science · doi:10.1126/science.275.5303.1126 · Cited by 341
Self-citationInohara, N., Koseki, T., Chen, S., Wu, X., & Núñez, G. (1998) · The EMBO Journal · doi:10.1093/emboj/17.9.2526 · Cited by 326
Self-citationIdentification of CARDIAK, a RIP-like kinase that associates with caspase-1
Thome, M., Hofmann, K., Burns, K., Martinon, F., Bodmer, J.-L., Mattmann, C., & Tschopp, J. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00352-1 · Cited by 319
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
Inohara, N., Koseki, T., Hu, Y., Chen, S., & Núñez, G. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.20.10717 · Cited by 316
Self-citationInteraction between the C. elegans cell-death regulators CED-9 and CED-4
Spector, M. S., Desnoyers, S., Hoeppner, D. J., & Hengartner, M. O. (1997) · Nature · doi:10.1038/385653a0 · Cited by 307
Chou, J. J., Matsuo, H., Duan, H., & Wagner, G. (1998) · Cell · doi:10.1016/s0092-8674(00)81417-8 · Cited by 302
Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis
Yang, X., Chang, H. Y., & Baltimore, D. (1998) · Science · doi:10.1126/science.281.5381.1355 · Cited by 269
Bodmer, J.-L., Burns, K., Schneider, P., Hofmann, K., Steiner, V., Thome, M., Bornand, T., Hahne, M., Schröter, M., Becker, K., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80244-7 · Cited by 262
WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation
Hu, Y., Ding, L., Spencer, D. M., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33489 · Cited by 257
Self-citationInohara, N., del Peso, L., Koseki, T., Chen, S., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.20.12296 · Cited by 245
Self-citationMiyamoto, S., Maki, M., Schmitt, M. J., Hatanaka, M., & Verma, I. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12740 · Cited by 206
IκB kinase: Beginning, not the end
Verma, I. M., & Stevenson, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.22.11758 · Cited by 199
Advances in apoptosis research
Peter, M. E., Heufelder, A. E., & Hengartner, M. O. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12736 · Cited by 199
Role of CED-4 in the activation of CED-3
Chinnaiyan, A. M., Chaudhary, D., O’Rourke, K. M., Koonin, E. V., & Dixit, V. M. (1997) · Nature · doi:10.1038/41913 · Cited by 194
Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death
Inohara, N., Gourley, T. S., Carrió, R., Muniz, M. E. B., Merino, J., Garcia, I., Koseki, T., Hu, Y., Chen, S., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32479 · Cited by 178
Self-citationInteraction and Regulation of the Caenorhabditis elegans Death Protease CED-3 by CED-4 and CED-9
Wu, D., Wallen, H. D., Inohara, N., & Núñez, G. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21449 · Cited by 130
Self-citationInohara, N., Ekhterae, D., Garcia, I., Carrió, R., Merino, J., Merry, A. C., Chen, S., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8705 · Cited by 129
Self-citationdel Peso, L., González, V. M., & Núñez, G. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.50.33495 · Cited by 105
Self-citationChin, K.-C., Li, G. G.-X., & Ting, J. P. ‐. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2501 · Cited by 101
Saksela, K., & Baltimore, D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3698 · Cited by 85
Chaudhary, D., O’Rourke, K. M., Chinnaiyan, A. M., & Dixit, V. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.28.17708 · Cited by 39
Flagged first, then by citations
Research works printed but not linked: 1
- Saksela, 1993, Mol. Cell. Biol., 13, 3698
Cited by
Sorted by citations
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
Hugot, J.-P., Chamaillard, M., Zouali, H., Lesage, S., Cézard, J.-P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., et al. (2001) · Nature · doi:10.1038/35079107 · Cited by 5,591
Toll-like receptors and innate immunity
Medzhitov, R. (2001) · Nature Reviews Immunology · doi:10.1038/35100529 · Cited by 4,308
Regulation and Function of NF-κB Transcription Factors in the Immune System
Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,635
Metadata
- Authors
- Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., & Núñez, G.
- Affiliations
- University of Michigan (US)
- Human Genome Sciences (United States) (US)
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-05
- Volume
- 274
- Issue
- 21
- Pages
- 14560-14567
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2119502087
- Cited by
- 742
- References
- 55
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 15 · 2023: 9 · 2022: 25 · 2021: 18 · 2020: 19 · 2019: 28 · 2018: 17 · 2017: 24 · 2016: 22 · 2015: 18 · 2014: 35 · 2013: 28 · 2012: 37
- FWCI
- 12.35
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- University of Michigan (T32GM07863)
- Japan Science and Technology Corporation
- National Institutes of Health (5r01ca064556-10, 5k04ca064421-03)
- National Cancer Institute (K04-CA64421, R01 CA64556)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- NOD1, Apaf-1, caspase-9, apoptosis, NF-κB activation, caspase recruitment domain, nucleotide-binding domain, leucine-rich repeats, cards, P-loop, TNF-α, innate immunity
- MeSH terms
- Amino Acid Sequence, Carrier Proteins, Chromosome Mapping, Humans, Molecular Sequence Data, Mutation, Proteins, NF-kappa B, Apoptosis, Caspases, Adaptor Proteins, Signal Transducing, Caspase 9, Nod1 Signaling Adaptor Protein, Apoptotic Protease-Activating Factor 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
