The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Single-molecule Enzymology
Open accessAbstract
Viewing a movie of an enzyme molecule made by molecular dynamics simulation, we see incredible details of molecular motions, be they changes of the conformation or actions during a chemical reaction. Molecular dynamics simulations have advanced our understanding of the dynamics of macromolecules in ways that would not be deducible from the static crystal structures (for review see Refs. 1 and 2). Unfortunately, these “virtual movies” do not run long enough compared with the time scale of milliseconds to seconds in which most enzymatic reactions take place.
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Citations
Cites
The Energy Landscapes and Motions of Proteins
Frauenfelder, H., Sligar, S. G., & Wolynes, P. G. (1991) · Science · doi:10.1126/science.1749933 · Cited by 3,250
Direct observation of the rotation of F1-ATPase
Noji, H., Yasuda, R., Yoshida, M., & Kinosita, K. (1997) · Nature · doi:10.1038/386299a0 · Cited by 2,236
Optical Trapping and Manipulation of Viruses and Bacteria
Ashkin, A., & Dziedzic, J. M. (1987) · Science · doi:10.1126/science.3547653 · Cited by 2,191
Fluorescence Spectroscopy of Single Biomolecules
Weiss, S. (1999) · Science · doi:10.1126/science.283.5408.1676 · Cited by 2,046
Thermodynamic Fluctuations in a Reacting System—Measurement by Fluorescence Correlation Spectroscopy
Magde, D., Elson, E., & Webb, W. W. (1972) · Physical Review Letters · doi:10.1103/physrevlett.29.705 · Cited by 1,753
Three-Dimensional Vibrational Imaging by Coherent Anti-Stokes Raman Scattering
Zumbusch, A., Holtom, G. R., & Xie, X. S. (1999) · Physical Review Letters · doi:10.1103/physrevlett.82.4142 · Cited by 1,626
Self-citationVisualization of Single RNA Transcripts in Situ
Femino, A. M., Fay, F. S., Fogarty, K., & Singer, R. H. (1998) · Science · doi:10.1126/science.280.5363.585 · Cited by 1,504
Single-Molecule Enzymatic Dynamics
Lu, H. P. (1998) · Science · doi:10.1126/science.282.5395.1877 · Cited by 1,470
Self-citationDynamics of Proteins and Nucleic Acids
Mccammon, J. A., Harvey, S. C., & Wolynes, P. G. (1988) · Physics Today · doi:10.1063/1.2811564 · Cited by 1,251
Funatsu, T., Harada, Y., Tokunaga, M., Saito, K., & Yanagida, T. (1995) · Nature · doi:10.1038/374555a0 · Cited by 1,047
Cited by
Zero-Mode Waveguides for Single-Molecule Analysis at High Concentrations
Levene, M. J., Korlach, J., Turner, S. W., Foquet, M., Craighead, H. G., & Webb, W. W. (2003) · Science · doi:10.1126/science.1079700 · Cited by 1,378
Probing Gene Expression in Live Cells, One Protein Molecule at a Time
Yu, J., Xiao, J., Ren, X., Lao, K., & Xie, X. S. (2006) · Science · doi:10.1126/science.1119623 · Cited by 918
Self-citationMovileanu, L., Howorka, S., Braha, O., & Bayley, H. (2000) · Nature Biotechnology · doi:10.1038/80295 · Cited by 366
Accurate Single-Molecule FRET Studies Using Multiparameter Fluorescence Detection
Sisamakis, E., Valeri, A., Kalinin, S., Rothwell, P. J., & Seidel, C. A. M. (2010) · Methods in Enzymology · doi:10.1016/s0076-6879(10)75018-7 · Cited by 268
Stochastic fluctuations in metabolic pathways
Levine, E., & Hwa, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610987104 · Cited by 132
Metadata
- Authors
- Xie, X. S., & Lu, H. P.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-06
- Volume
- 274
- Issue
- 23
- Pages
- 15967-15970
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1563322259
- Cited by
- 268
- References
- 51
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Xie, X. S., & Lu, H. P. (1999). Single-molecule Enzymology. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.23.15967
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
