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The Proteasome, a Novel Protease Regulated by Multiple Mechanisms
Open accessAbstract
Investigators have long recognized the potential importance of protein degradation as a mechanism for regulating levels of cellular proteins (1-3). Nevertheless, only recent studies of the ubiquitin-proteasome pathway have shown how extensively proteolysis is involved in the regulation of crucial cellular processes such as: progression of the cell cycle, oncogenesis, transcription, development, growth and atrophy of developed tissues, flux of substrates through metabolic pathways, selective elimination of abnormal proteins, and antigen processing.
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Citations
Cited by
The proteasome: a suitable antineoplastic target
Adams, J. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1361 · Cited by 1,201
Ubiquitin-mediated proteolysis: biological regulation via destruction
Ciechanover, A., Orian, A., & Schwartz, A. L. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200005)22:5<442::aid-bies6>3.0.co;2-q · Cited by 853
Nuclear retinoid receptors and the transcription of retinoid-target genes
Bastien, J., & Rochette-Egly, C. (2004) · Gene · doi:10.1016/j.gene.2003.12.005 · Cited by 773
Age-related decline in chaperone-mediated autophagy
Cuervo, A. M., & Dice, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002102200 · Cited by 665
The autophagosomal–lysosomal compartment in programmed cell death
Bursch, W. (2001) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4400852 · Cited by 616
Metadata
- Authors
- DeMartino, G. N., & Slaughter, C. A.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1999-08
- Volume
- 274
- Issue
- 32
- Pages
- 22123-22126
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2164710551
- Cited by
- 530
- References
- 0
- FWCI
- 17.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: The Proteasome, a Novel Protease Regulated by Multiple Mechanisms. https://app.cochat.ai/papers/10.1074/jbc.274.32.22123
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- DeMartino, G. N., & Slaughter, C. A. (1999). The Proteasome, a Novel Protease Regulated by Multiple Mechanisms. Journal of Biological Chemistry. https://doi.org/10.1074/jbc.274.32.22123
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
